可溶性补体受体2在干燥综合征患者血清中的变化及意义

Changes and Significance of Serum Soluble Complement Receptor 2 in Patients with Primary Sjogren’s Syndrome

摘要: 目的：探讨原发性干燥综合征(pSS)患者血清中可溶性补体受体2(sCR2)的变化及意义。方法：采用ELISA法检测20例原发性干燥综合征患者和20例健康体检者血清中可溶性补体受体2的浓度，并用SPSS统计软件进行相关统计学分析。结果：pSS患者sCR2水平均明显低于健康体检者(P均<0.01)，sCR2与年龄和性别无关，特别是PSS患者中抗体阳性组血清sCR2水平低于阴性对照组，存在显著的统计学意义(P < 0.05)，而且pSS患者血清sCR2水平与免疫球蛋白IgG及血沉存在明显负相关。结论：pSS患者血清sCR2水平明显降低，且与免疫球蛋白IgG及血沉存在明显负相关，提示sCR2可能参与pSS的发病过程。

Abstract: Aim: Changes and significance of serum soluble complement receptor 2 (sCR2) in patients with primary Sjogren’s syndrome (pSS) are discussed. Methods: ELISA was developed for the determination of sera sCR2 concentration in sera of 20 pSS patients and 20 healthy volunteers. Statistical analysis was performed by using SPSS software. Results: The level of serum sCR2 in patients with pSS was significantly lower than that in healthy control (P < 0.01). In addition, there was no correlation between patients’ age and sex in sCR2 levels. The level of serum sCR2 in the self-antibody positive group was lower than that in the negative control group, and there was significant statistical significance (P < 0.05). In addition, the level of serum sCR2 in pSS patients showed negative correlation with immunoglobulin IgG and ESR level. Conclusions: The evident decrease of serum sCR2 level in pSS patients has negative correlation with the levels of immunoglobulin IgG and ESR, which suggests that sCR2 may play a critical role in the pathogenesis of pSS.