体部伽玛刀联合射频消融治疗肺转移瘤的疗效观察

Observation of Body Gamma Knife Combined with Radiofrequency Ablation Therapy for Lung Metastases

摘要: 目的：观察体部伽玛刀联合射频消融治疗肺转移瘤的近期疗效和毒副反应。方法：伽玛刀联合射频消融治疗10例肺转移瘤患者，伽玛刀治疗剂量4~9 Gy/次，隔日治疗一次，治疗次数为5~10次，总剂量为36~50 Gy；肿瘤 > 5 cm的先行放疗结束后1~2周进行射频消融治疗，肿瘤 < 5 cm的先行射频消融后1~2周进行放疗，治疗1次即可。结果：治疗后2~3个月所有患者得到随访，其中完全缓解率20.0% (2/10)，部分缓解率为70.0% (7/10)，总有效率为90.0% (9/10)；骨髓抑制为主要并发症，发生率为60.0% (6/10)。结论：SBRT联合RFA治疗肺转移瘤近期疗效好，副反应轻可耐受，值得临床推广。

Abstract: Objective: To observe the treatment efficacy and toxicity reaction of lung metastases by using body gamma knife combined with radiofrequency ablation therapy. Methods: 10 cases of lung metastases patients were treated by gamma knife combined with radiofrequency ablation. The gamma knife treatment dose was 4 - 9 Gy, treat every other day, the number of treatment was 5 - 10 times with a total dose of 36 - 50 Gy; when tumor > 5 cm, it was treated with radiotherapy first, then after 1 - 2 weeks, radiofrequency ablation was applied; when tumor < 5 cm, radiofrequency ablation was applied first, after 1 - 2 weeks, radiation therapy was done, and the treatment of radiofrequency ablation only needed once. Results: after the treatment of 2 - 3 months, all patients were followed up, the complete remission rate was 20% (2/10), response rate was 70% (7/10), the total effective rate was 90% (9/10); bone marrow suppression was the main complication, the incidence rate was 60% (6/10). Conclusion: SBRT combined with RFA in the treatment of lung metastases, with mild side effects that can be tolerated, is worth the clinical promotion.