低分子肝素钙对恶性肿瘤患者D-二聚体和PICC管堵塞的影响

Effect of Low Molecular Weight Heparin on D-Dimer and PICC Tube Blockage of Malignant Cancer Patients

摘要: 目的：探讨低分子肝素钙对恶性肿瘤患者D-二聚体和PICC管堵塞的影响，及抗凝治疗对PICC导管堵塞的干预效果。方法：选择D-二聚体偏高并置有PICC导管的恶性肿瘤患者30例，随机分为两组，测定15例(治疗组)接受低分子肝素钙治疗后D-二聚体的变化，同时检测15例(对照组) D-二聚体值进行对比观察。结果：与治疗前比较，低分子肝素治疗组在治疗后的2、4和7天的降低率为49.22%、50.18%和61.92%；对照组患者的D-二聚体在治疗后2、4和7天的降低率为6.00%、22.13%和13.57%。治疗组的下降率高于对照组。同时，低分子肝素治疗组抗凝后出现1例PICC导管堵塞，堵管率为6.67%，对照组出现10例PICC导管堵塞，堵管率为66.67%。结论：恶性肿瘤患者存在血液高凝及凝血功能紊乱，经低分子肝素钙治疗后可明显改善症状，降低血浆D-二聚体水平，同时减少PICC导管的堵塞，值得临床推广和应用。

Abstract: Objective: To investigate the effect of low molecular weight heparin in patients with cancer D- dimer and PICC tube blockage, and anticoagulation effect of interference PICC catheter blockage. Methods: D-dimer High malignancy in patients with PICC catheter 30 patients were randomly divided into two groups, measured 15 cases (treatment group) accept change after low molecular weight heparin therapy D-dimer, while detected 15 cases (control group) D-dimer values were compared. Results: The treatment with relatively low molecular weight heparin in the treat- ment group at 2, 4 and 7 days after treatment reduced rate of 49.22%, 50.18% and 61.92%; the control group of patients after treatment 2,4 D-dimer and 7 days reduced rate of 6.00%, 22.13% and 13.57%. The rate of decline in treatment group is higher than the control group. Meanwhile, the low molecular weight heparin anticoagulant therapy group 1 case PICC catheter blockage, plugging rate of 6.67% in the control group had 10 cases of PICC catheter obstruction, plugging rate was 66.67%. Conclusion: Cancer patients hypercoagulable and coagulation disorders, the low molecular weight heparin treatment can significantly improve symptoms, reduce plasma D-dimer levels, while reducing the PICC catheter blockage, worthy of promotion and application.