SII、MLR与慢性淋巴细胞性甲状腺炎的相关性研究

The Relationship between SII, MLR and Chronic Lymphocytic Thyroiditis

摘要: 目的：探究SII、MLR与女性慢性淋巴细胞性甲状腺炎(Chronic lymphocytic thyroiditis, CLT)之间的关系。方法：本研究纳入70名甲状腺功能正常的女性CLT患者和70名年龄相匹配的健康女性作为对照组，比较两组之间的系统免疫炎症指数(Systematicimmune-inflammatory index, SII)、单核细胞淋巴细胞比值(Monocyte-to-lymphocyte ratio)、血小板计数(Platelet count)、单核细胞计数(Monocyte count)、中性粒细胞计数(neutrophil count)、淋巴细胞计数(Lymphocyte count)、促甲状腺激素(Thyroidstimulating hormone, TSH)、抗甲状腺过氧化物酶抗体(Anti-TPO)、抗甲状腺球蛋白抗体(Anti-TG)有无差异，对组数据进行Logistic回归分析CLT的危险因素，pearson分析CLT组内的SII、MLR与TSH、Anti-TPO及Anti-Tg之间的相关性。结果：CLT组患者的年龄、BMI、单核细胞计数、中性粒细胞计数、淋巴细胞计数、血小板计数、游离甲状腺素(Free T₄, FT₄)、游离三碘甲状腺原氨酸(Free T3, FT₃)与正常对照组相比无显著差异(p > 0.05)。CLT组患者的SII、MLR、TSH、Anti-Tg、Anti-TPO均高于正常对照组，且差异有统计学意义(p < 0.05)。Logistic回归分析显示SII、MLR是CLT的危险因素(p < 0.05)。Pearson相关分析显示，SII、MLR分别与血清TSH水平、Anti-Tg及Anti-TPO滴度相关，且差异有统计学意义(p < 0.05)。结论：本研究发现甲状腺功能正常的女性CLT患者SII、MLR高于健康对照组。SII、MLR可能是免疫功能紊乱的非特异指标，可能对CLT有预测作用。SII、MLR对CLT的影响需要进一步研究。

Abstract: Objective: Exploring the correlation between Systematic Immune-inflammatory Index (SII), Mono-cyte-to-Lymphocyte Ratio (MLR) and CLT in women with normal thyroid function. Methods: 70 CLT women with normal thyroid function and 70 healthy controls of similar age are enrolled in the study. We compare SII, MLR, Platelet count, Neutrophil count, Lymphocyte count, Thyroid Stimulating Hormone (TSH), Thyroid Peroxidase Antibodies (TPO-Ab) and Thyroglobulin Antibodies (TG-Ab) between the two groups to indicate whether there is a difference. We make logistic analysis to make sure the danger factors of CLT. And we also analyze the correlation between SII, MLR and TSH, Anti-TPO and Anti-Tg within CLT group. Results: Age, BMI, platelet count, monocyte count, neutrophil count, lymphocyte count, FT₄, and FT₃ of patients in the CLT group are not significantly different compared with the control group (p > 0.05). The SII, MLR, TSH, Anti-Tg and Anti-TPO of the CLT group are higher than the control group, and the difference is statistically significant (p < 0.05). Logistic analysis exposed that SII and MLR are the risk factors of CLT. Pearson correlation analysis indicated that SII, MLR are correlated with serum TSH, Anti-Tg and Anti-TPO respectively, and the difference was statistically significant (p < 0.05). Conclusion: In this study, SII, MLR of CLT patients with normal thyroid function are higher than that of healthy controls. SII, MLR may be nonspecific indicators of immune dysfunction and may be predictors of CLT. The effect of SII and MLR on CLT needs further studys.