《二十四史》及《清史稿》罕见性遗传性相关疾病考

A Study on Rare Genetic Diseases Historically Reviewed in 24 Ancient History Books and Historical Manuscripts of Qing Dynasty

摘要: 根据现代遗传学知识，从中国25部历史书籍“五行志”篇中检索与遗传性相关的疾病症状，疑为遗传性或先天性相关疾病89例，计有：遗传系统性疾病(环境与遗传交叉)、先天性疾病(遗传异质性)、染色体异常、多基因疾病、显性基因疾病、基因重组、基因突变、肿瘤、基因表达紊乱、不明原因等10类遗传相关性疾病。 By reference to modern genetic disease diagnostic criteria, there were 89 cases with symptoms relevant to genetic inheritance reported in the chapter Wu Xing Zhi: 5 Elements of the 24 books and historical manuscripts of Qing dynasty of China. Ten types of genetic disorders were described: interaction between genetic and environment, congenital of genetic heterogeneity, chromosome abnormality, polygene, dominant, recombination, mutation, tumor, expressing abnormal and no explaining cause.