中药及其有效成分对血脑屏障作用的研究进展
Research Progress of the Effects of Traditional Chinese Medicine and Its Active Ingredients on the Blood Brain Barrier
DOI: 10.12677/PI.2013.22004, PDF, HTML, XML,  被引量 下载: 3,873  浏览: 16,802  国家科技经费支持
作者: 顾泉琳：广东药学院中医药研究院，广州；贝伟剑*：国家中医药管理局脂代谢三级实验室及高脂血症调肝降脂重点研究室，广州
关键词: 血脑屏障；中药；有效成分；Blood-Brain Barrier; Traditional Chinese Medicine; Active Ingredients
摘要: 血脑屏障是大脑脉管系统维持脑组织环境和功能稳定的重要特性。脑毛细管内皮细胞间的紧密连接(TJ)是血脑屏障的结构基础，它由跨膜蛋白、胞浆粘附蛋白和连接黏附分子及细胞骨架蛋白等共同组成，维持脑毛细血管内皮机械屏障和通透性。中药对多种脑源性疾病具有良好的疗效，这与中药有效成分透过血脑屏障或改善血脑屏障的形态结构和功能有关。
Abstract: The blood brain barrier (BBB) is the important characteristic of the cerebral vasculature for maintaining the homeostasis of the brain environment and its function. The tight junctions (TJs) closely connecting the brain capillary endothelial cells (TJ) are the structural basis of BBB, which are composed of a transmembrane protein, intracellular adhesion protein and junctional adhesion molecules and cytoskeletal proteins, maintaining the brain capillary endothe-lial barrier and permeability. Traditional Chinese medicine (TCM) has excellent curative effect on various brain diseases, which might owe to the permeance of their active ingredients through the BBB and their effects of improving the morphological structure and function of the BBB.
文章引用：顾泉琳, 贝伟剑. 中药及其有效成分对血脑屏障作用的研究进展[J]. 药物资讯, 2013, 2(2): 12-18. http://dx.doi.org/10.12677/PI.2013.22004

参考文献

[1] D. Shlosberg, M. Benifla, D. Kaufer, et al. Blood-brain barrier break-down as a therapeutic target in traumatic brain injury. Na- ture Reviews Neurology, 2010, 6(7): 393-403.
[2] W. M. Pardridge. Drug transport across the blood-brain barrier. Journal of Cerebral Blood Flow & Me-tabolism, 2012, 32(11): 1959-1972.
[3] K. Malpass. New methods to permeabilize the blood-brain bar- rier. Nature Reviews Neurology, 2011, 7(11): 597.
[4] R. Daneman. The blood-brain barrier in health and disease. Annals of Neurology, 2012, 72(5): 648-672.
[5] S. J. Tam, R. J. Watts. Connecting vascular and nervous system develop-ment: Angiogenesis and the blood-brain barrier. Annual Review of Neuroscience, 2010, 33: 379-408.
[6] 罗瑞静, 何建成. 中药对血脑屏障的影响及其展望[J]. 中华中医药学刊, 2011, 29(5): 1021-1023.
[7] 黄少然. 中医药治疗心脑血管病社会优势渐凸显[J]. 中国处方药, 2009, 92(11): 54-55.
[8] M. Takeichi. Shoichiro Tsukita: A life exploring the molecular architecture of the tight junction. The Journal of Cell Biology, 2006, 172(3): 321-323.
[9] M. Fromm, S. M. Krug, S. Zeissig, et al. High-resolution analy- sis of barrier func-tion. Annals of the New York Academy of Sciences, 2009, 1165: 74-81.
[10] H. Chiba, M. Osanai, M. Murata, et al. Transmembrane proteins of tight junctions. Biochimica et Biophysica Acta, 2008, 1778(3): 588-600.
[11] J. Ikenouchi, H. Sasaki, S. Tsukita, et al. Loss of occludin affects tricellular localization of tricellulin. Molecular Biology of the Cell, 2008, 19(11): 4687-4693.
[12] J. Ikenouchi, M. Furuse, K. Furuse, et al. Tricellulin constitutes a novel barrier at tricel-lular contacts of epithelial cells. The Jour- nal of Cell Biology, 2005, 171(6): 939-945.
[13] S. M. Krug, S. Amasheh, J. F. Richter, et al. Tricellulin forms a barrier to macromolecules in tricellular tight junc-tions without affecting ion permeability. Molecular Biology of the Cell, 2009, 20(16): 3713-3724.
[14] K. Umeda, J. Ikenouchi, S. Kata-hira-Tayama, et al. ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell, 2006, 126(4): 741-754.
[15] K. Ebnet, M. Aurrand-Lions, A. Kuhn, et al. The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: A possible role for JAMs in endothelial cell polarity. Journal of Cell Science, 2003, 116: 3879-3891.
[16] N. J. Abbott. Dynamics of CNS barriers: Evolu-tion, differentia- tion, and modulation. Cellular and Molecular Neuro-biology, 2005, 25(1): 5-23.
[17] 李国菁, 王行宽. 中医对脑的认识[J]. 吉林中医药, 2010, 30(8): 647-648.
[18] 贾晓旭, 康立源. 开窍药研究概况[J]. 中国中医药信息杂志, 2010, 17(4): 108-112.
[19] 倪彩霞, 曾南, 汤奇等. 芳香开窍药对正常小鼠血脑屏障通透性的影响[J]. 江苏中医药, 2011(3), 43(2): 88-89.
[20] 李毓敬, 朱亮锋, 麦浪天等. 中药冰片及其来源[J]. 植物杂志, 1988, 9: 17.
[21] 国家药典委员会. 中华人民共和国药典(一部)[M]. 北京: 化学出版社, 2005.
[22] 万德光, 彭成, 卫莹芳等编写, 赵军宁主编. 四川道地中药材志[M]. 成都: 四川科学技术出版社, 2005: 564.
[23] 黄康泰. 天然常用中药成分与药理手册[M]. 北京: 中国医药科技出版社, 1999.
[24] 俞波. 麝香雄甾烷类化合物的分离与鉴定[J]. 药物分析杂志, 1989, 9(5): 263-265.
[25] 陈艳明, 王宁生. 冰片对血脑屏障体外模型细胞间紧密连接和细胞吞饮囊泡的影响[J]. 中国中西医结合杂志, 2004, 24(7): 632-634.
[26] 刘养凤, 张军平, 张伯礼等. 冰片对大鼠下丘脑单胺类神经递质的影响[J]. 中国中医药信息杂志, 2004, 11(2): 122-124.
[27] 李伟荣, 姚丽梅, 宓穗卿等. 冰片对大鼠下丘脑组胺、5-羟色胺含量的影响[J]. 中药材, 2004, 27(12): 937-939.
[28] 陈艳明, 王宁生. 冰片对P-糖蛋白的影响[J]. 中药新药与临床药理, 2003, 14(2): 96-98.
[29] 赵保胜, 徐勤, 宓穗卿. 冰片促血脑屏障开放与一氧化氮含量改变的关系初探[J]. 脑与神经疾病杂志, 2001, 9(4): 207- 209.
[30] 葛朝莉, 韩漫夫, 白润涛等. 冰片促进血脑屏障开放的超微结构研究[J]. 中西医结合心脑血管病杂志, 2008, 10: 1183- 1185.
[31] 陈文垲, 黄玉芳, 王海东. 麝香“归经入脑”的实验研究[J]. 中西医结合学报, 2004, 2(4): 288-291.
[32] 李瑾翡, 王宁生, 陆惠文等. 麝香酮药代动力学研究[J]. 中药新药与临床药理, 2000, 11(4): 208-210.
[33] 唐洪梅, 李锐. 石菖蒲透过大鼠血脑屏障的化学成分分析[J]. 中医药研究, 2002, 18(1):40.
[34] 胡园, 袁默, 刘屏等. 石菖蒲对血脑屏障超微结构及通透性的影响[J]. 中国中药杂志, 2009, 34(3): 349.
[35] 高玉琼, 刘建华, 霍昕. 石菖蒲挥发油成分的研究[J]. 贵阳医学院学报, 2003, 28(1): 31.
[36] 陈晨, 刘倩, 高华. 活血化瘀药药理作用研究进展[J]. 中国药事, 2011, 25(6): 603-605.
[37] 张素平, 何锐, 王慕真等. 活血化瘀药对大鼠脑缺血再灌注损伤的保护作用时效量效关系对照验证(英文)[J]. 中国临床康复, 2005, 9(25): 226-229.
[38] 朱海燕, 高永红, 马涛等. 三七总皂苷对铝暴露体外血脑屏障通透性的影响[J]. 中西医结合心脑血管病杂志, 2011, 9(11): 1359-1361.
[39] 叶龙彬, 奚涛, 陈峰等. 丹参酮ⅡA对大鼠局灶性脑缺血再灌注损伤的保护作用[J]. 中国药科大学学报, 2004, 35(3): 267-270.
[40] 唐宇平, 蔡定芳, 刘军等. 大黄改善急性脑出血大鼠血脑屏障损伤的水通道蛋白-4机理研究[J]. 中国中西医结合杂志, 2006, 26(2): 152-156.
[41] 胡金林. 天麻的药理作用与临床应用[J]. 中国乡村医药, 2009, 16(3): 76-81.
[42] 卢薇, 黄玉芳, 丁兴. 天麻有效成分香兰素入脑途径的研究[J]. 江苏中医药, 2006, 27(2): 55-56.
[43] 陈光亮, 姚道云, 汪远金等. 薄荷油药理作用和急性毒性的研究[J]. 中药药理与临床, 2001, 17(1): 10-12.
[44] 黄秀旺, 许建华, 陈元仲. 雷公藤内酯醇在大鼠体内的组织分布[J]. 中国临床药理学与治疗学, 2008, 13(7): 764-767.
[45] F. Shao, G. Wang, H. Xie, et al. Phar-macokinetic study of tripto- lide, a constituent of immunosuppressive chinese herb medicine, in rats. Biological & Pharmaceutical Bulletin, 2007, 30(4): 702- 707.
[46] G. T. Manley, M. Fujimura, T. Ma, et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nature Medicine, 2000, 6(2): 159-163.
[47] 郭瑞友, 于义英, 方思羽等. 海风藤对局灶性脑缺血治疗作用的实验研究[J]. 中西医结合心脑血管病杂志, 2003, 1(8): 461-462.
[48] 陈峰, 袁媛, 李泽友等. 黄酮类化合物组织分布研究进展[J]. 中国药房, 2007, 18(30): 2379-2382.
[49] C. Rice-Evans. Flavonoid antioxidants. Current Medicinal Chemistry, 2001, 8(7): 797-807.
[50] H. Cai, D. J. Boocock, W. P. Steward, et al. Tissue dis-tribution in mice and metabolism in murine and human liver of api-genin and tricin, flavones with putative cancer chemopreventive prop- erties. Cancer Chemotherapy and Pharmacology, 2007, 60(2): 257-266.
[51] 巩沅鑫, 周其全. 银杏叶提取物对血脑屏障通透性保护作用的分子机制[J]. 中国新药杂志, 2008, 17(17): 1474-1481.
[52] 陈春富, 郭述苏, 冯林等. 黄芪对大鼠脑缺血血脑屏障及脑血流的影响[J]. 卒中与神经疾病杂志, 1989, 5(3): 132-134.
[53] 孙蓉, 吕丽莉, 郭守东等. 芍药苷对局灶性脑缺血模型及血脑屏障的影响[J]. 哈尔滨商业大学学报(自然科学版), 2005, 21(4): 405-410.
[54] M. L. Wang, X. J. Huang, S. H. Fang, et al. Leu-kotriene D4 induces brain edema and enhances CysLT2 recep-tor-mediated aquaporin 4 expression. Biochemical and Biophysical Research Communications, 2006, 350(2): 399-404.
[55] 董先智, 汤小爱, 高秋华等. 冰片对顺铂透血脑屏障促进作用的研究[J]. 中国药学杂志, 2002, 37(4): 275-277.
[56] H. Onishi, M. Yamaguchi, K. Kuriyama, et al. Effect of concur- rent intra-arterial infusion of plati-num drugs for patients with stage III or IV uterine cervical cancer treated with radical radia- tion therapy. Cancer Journal From Scientific American, 2000, 6(1): 40-45.
[57] 薛洪利, 孔令权, 董宝印. 罂粟碱可逆性开放血脑屏障的实验及临床应用[J]. 中华医学杂志, 1995, 75(1): 42.