论利用动物模型研究中医证候的可能性及其限度

Possibilities and Limits of Using Animal Models to Research Traditional Chinese Medicine Syndrome

摘要: 经过分析，本文发现所谓“人的主观感觉不能复制”的观点不完全正确，形成主观感受的客观基础是可以在动物复制的，从而为采用动物模型研究中医证候提供了部分理论上的根据；并提出了两个增强中医证候动物模型研究可靠性和准确性的方法：用内源性物质制作表型组合的方法；基于中医阴阳的基本原理的“连续动态造模–反向匹配”方法。This paper finds that the viewpoint that subjective perception of people can’t be reproduced in animals is not exactly true. The objective basis underlying subjective perception of people can be copied in animals, which thus pro- vides some theoretical grounds for using animal models to research traditional Chinese medicine syndrome. We also suggest two methods of enhancing the reliability and accuracy of animal models for traditional Chinese medicine syndrome. One is to generate phenotype combination by use of endogenous substance, the other is a method named “continuously dynamic modeling-reverse match” based on fundamental principle of Yin-Yang in traditional Chinese medicine.