丙泊酚的非麻醉作用的研究进展

Advances in Studies on the Non-Anaesthetic Effects of Propofol

摘要: 丙泊酚做为一种短效的静脉麻醉剂不仅是在手术室，而且也在其他科室得到广泛的应用。除了它的具有的多种麻醉优点外，近来的研究发现丙泊酚也有一些非麻醉的效应。丙泊酚参与了NOS/NO通路；具有抗焦虑的特性；同时，它具有抗氧化、免疫调节、止痛、止吐和神经保护作用。丙泊酚的这些非麻醉的特性可能扩大丙泊酚的临床应用。 Propofol is a short-acting intravenous anaesthetic agent which has gained wide acceptance not only in oper-ating rooms but also in other departments, due to its several advantages. Apart from its multiple anaesthetic advantages, it has been reported recently that propofol exerts a number of nonanaesthetic effects. Propofol is involved in NOS/NO pathway and has anxiolytic properties. Moreover, it has antioxidant, immunomodulatory, analgesic, antiemetic and neuroprotective effects. All these nonanaesthetic properties may expand the clinical use of propofol.