生理学研究  >> Vol. 1 No. 2 (August 2013)

丙泊酚的非麻醉作用的研究进展
Advances in Studies on the Non-Anaesthetic Effects of Propofol

DOI: 10.12677/JPS.2013.12002, PDF, HTML, XML, 下载: 3,246  浏览: 12,416 

作者: 萧朱, 朱伟:广东医学院分子诊断重点实验室分子病理平台,东莞;武蕾洁, 龙军:中山大学中山医学院,广州;陈志红, 罗辉*:广东医学院药学院药理教研室,湛江

关键词: 丙泊酚非麻醉效应综述Propofol; Nonanaesthetic Effects; Review

摘要: 丙泊酚做为一种短效的静脉麻醉剂不仅是在手术室,而且也在其他科室得到广泛的应用。除了它的具有的多种麻醉优点外,近来的研究发现丙泊酚也有一些非麻醉的效应。丙泊酚参与了NOS/NO通路;具有抗焦虑的特性;同时,它具有抗氧化、免疫调节、止痛、止吐和神经保护作用。丙泊酚的这些非麻醉的特性可能扩大丙泊酚的临床应用。 Propofol is a short-acting intravenous anaesthetic agent which has gained wide acceptance not only in oper-ating rooms but also in other departments, due to its several advantages. Apart from its multiple anaesthetic advantages, it has been reported recently that propofol exerts a number of nonanaesthetic effects. Propofol is involved in NOS/NO pathway and has anxiolytic properties. Moreover, it has antioxidant, immunomodulatory, analgesic, antiemetic and neuroprotective effects. All these nonanaesthetic properties may expand the clinical use of propofol.

文章引用: 萧朱, 武蕾洁, 陈志红, 龙军, 朱伟, 罗辉. 丙泊酚的非麻醉作用的研究进展[J]. 生理学研究, 2013, 1(2): 7-10. http://dx.doi.org/10.12677/JPS.2013.12002

参考文献

[1] J. A. Gonzalez-Correa, et al. Effects of propofol on the leukocyte nitric oxide pathway: In vitro and ex vivo studies in surgical patients. Naunyn-Schmiedeberg’s Archives of Pharmacology, 2008, 376(5): 331-339.
[2] H. K. Song, D. C. Jeong. The effect of propofol on cytotoxicity and apoptosis of lipopolysaccharide-treated mononuclear cells and lymphocytes. Anesthesia & Analgesia, 2004, 98(6): 1724- 1728.
[3] Y. C. Liu, et al. Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia. Journal of Biomedical Science, 2009, 16: 8.
[4] X. P. Dong, T. L. Xu. The actions of propofol on gamma-ami- nobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat. Anesthesia & Analgesia, 2002, 95(4): 907-914.
[5] O. H. Wilder-Smith, M. Kolletzki and C. H. Wilder-Smith. Sedation with intravenous infusions of propofol or thiopentone. Effects on pain perception. Anaesthesia, 1995, 50(3): 218-222.
[6] Y. C. Tsai, et al. Propofol does not reduce infarct volume in rats undergoing permanent middle cerebral artery occlusion. Acta anaesthesiologica Sinica, 1994, 32(2): 99-104.
[7] C. Liang, et al. Propofol attenuates cerebral ischemia/reperfu- sion injury partially using heme oxygenase-1. Journal of Neurosurgical Anesthesiology, 2013, 25(3): 311-316.
[8] J. He, et al. Propofol exerts hippocampal neuron protective effects via up-regulation of metallothionein-3. Neurological Sciences, 2013, 34(2): 165-171.
[9] L. J. Velly, et al. Neuroprotective effects of propofol in a model of ischemic cortical cell cultures: Role of glutamate and its transporters. Anesthesiology, 2003, 99(2): 368-375.
[10] C. Adembri, et al. Neuroprotective effects of propofol in models of cerebral ischemia: Inhibition of mitochondrial swelling as a possible mechanism. Anesthesiology, 2006, 104(1): 80-89.
[11] 李岩, 陈国忠, 刘韧等. 异丙酚减轻大鼠创伤性脑水肿及相关机制的研究. 医学综述, 2009, 15(9): 1410-1412.
[12] M. Coburn, et al. Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia. British Journal of Anaesthesia, 2008, 100(6): 787- 791.
[13] A. Borgeat, H. R. Stirnemann. Antiemetic effect of propofol. Anaesthesist, 1998, 47(11): 918-924.
[14] A. Borgeat, et al., Propofol and spontaneous movements: An EEG study. Anesthesiology, 1991, 74(1): 24-27.
[15] B. L. Appadu, P. G. Strange and D.G. Lambert. Does propofol interact with D2 dopamine receptors? Anesthesia & Analgesia, 1994, 79(6): 1191-1192.
[16] S. A. Helmy, R. J. Al-Attiyah. The im-munomodulatory effects of prolonged intravenous infusion of propofol versus midazolam in critically ill surgical patients. Anaesthesia, 2001, 56(1): 4-8.
[17] A. Kushida, T. Inada and K. Shingu. Enhancement of antitumor immunity after propofol treatment in mice. Immunopharmacology and Immunotoxicology, 2007, 29(3-4): 477-486.
[18] V. Volke, et al. Inhibition of nitric oxide synthase causes anxiolytic-like behaviour in an elevated plus-maze. Neuroreport, 1995, 6(10): 1413-1416.
[19] A. D. Manataki, et al. Lipid peroxidation and the use of emulsified propofol in laparoscopic surgery. Surgical Endoscopy, 2001. 15(9): 950-953.
[20] P. Sanchez-Conde, et al. The comparative abilities of propofol and sevoflurane to modulate inflammation and oxidative stress in the kidney after aortic cross-clamping. Anesthesia & Analge- sia, 2008, 106(2): 371-378.