放射性白内障的研究进展
Research Advances in Radiation Cataract
DOI: 10.12677/HJO.2013.23004, PDF, HTML, XML,  被引量 下载: 3,190  浏览: 13,739 
作者: 孙海华, 吴志鸿*:中国武警总医院眼科, 北京
关键词: 辐射剂量暴露类型白内障Radiation Doses; Exposure Type; Cataract
摘要: 晶状体是人体内对辐射最为敏感的组织之一,少于2 Gy急性辐射剂量的低电离辐射和少于5 Gy的长期辐射能诱导白内障。尽管在这一领域已经进行了许多研究,放射性白内障形成的机制还没有完全明确。深入了解放射性白内障形成的机制及剂量阈值,将有助于理解放射性白内障的形成,在促进放射性白内障的研究及临床治疗中起到重要作用。
Abstract: The lens of the eye is recognized as one of the most radiosensitive tissues in the human body, and it is known that cataracts can be induced by acute doses of less than 2 Gy of low-LET ionizing radiation and less than 5 Gy of pro- tracted radiation. Although much work has been carried out in this area, the exact mechanisms of radiation cataracto- genesis are still not fully understood. In-depth understanding of nuclear radiation cataract formation mechanism and dose threshold, will help to understand the whole process of radioactive nuclear cataract formation, and that will play an important role in promoting nuclear radiation cataract research and clinical treatment.
文章引用:孙海华, 吴志鸿. 放射性白内障的研究进展[J]. 眼科学, 2013, 2(3): 17-22. http://dx.doi.org/10.12677/HJO.2013.23004

参考文献

[1] T. Malmström, R. H. Kröger. Pupil shapes and lens optics in the eyes of terrestrial vertebrates. Journal of Experimental Biology, 2006, 209(1): 18-25.
[2] M. Ahmed, N. Rahman. ATM and breast cancer susceptibility. Oncogene, 2006, 25(43): 5906-5911.
[3] B. V. Worgul, L. Smilenov, D. J. Brenner, A. Junk, W. Zhou and E. J. Hall. Atm het-erozygous mice are more sensitive to radia- tion-induced cataracts than are their wild-type counterparts. Proceedings of the National Academy of Sciences of the United States of America, 2002, 99(15): 9836-9839.
[4] N. J. Kleiman, J. David, C. D. Elliston, K. M. Hop-kins, L. B. Smilenov, D. J. Brenner, B. V. Worgul, E. J. Hall and H. B. Lie- berman. Rad9 and Atm haploinsufficiency enhance spontaneous and X-ray-induced cataractogenesis in mice. Radiation Research, 2007, 168(5): 567-573.
[5] B. V. Worgul, L. Smilenov, D. J. Brenner, M. Vazquez and E. J. Hall. Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypes. Advances in Space Research, 2005, 35(2): 254-259.
[6] G. R. Mer-riam Jr., E. F. Focht. A clinical study of radiation cataracts and the relationship to dose. American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine, 1957, 77(5): 759-785.
[7] ICRP. 1990 Recommendations of the International Commission on Radio-logical Protection. Publication 60, Annals of the ICRP, Vol. 21, Am-sterdam: Elsevier, 1991.
[8] ICRP. The 2007 Recommendations of the International Commission on Radiological Protection. Publication 103, Annals of the ICRP, Vol. 37, Amsterdam: Elsevier, 2007.
[9] K. Neriishi, E. Nakashima, A. Minamoto, S. Fujiwara, M. Akahoshi, H. K. Mishima, T. Kitaoka and R. E. Shore. Postoperative cataract cases among atomic bomb survivors, radiation dose re- sponse and threshold. Radiation Research, 2007, 168(4): 404- 408.
[10] E. Nakashima, K. Neriishi and A. Minamoto. A reanalysis of atomic-bomb cataract data, 2000-2002: A threshold analysis. Health Physics, 2006, 90(2):154-160.
[11] P. Hall, F. Granath, M. Lundell, K. Olsson and L. E. Holm. Lenticular opacities in individuals exposed to ionizing radia-tion in infancy. Radiation Research, 1999, 152(2): 190-195.
[12] G. Chodick, N. Bekiroglu, M. Hauptmann, B. H. Alexander, D. M. Freedman, M. M. Doody, L. C. Cheung, S. L. Simon, R. M. Weinstock and A. J. Sigurdson. Risk of cataract after exposure to low doses of radiation: a 20-year prospective cohort study among US radiologic technologists. American Journal of Epidemiology, 2008, 168(6): 620-631.
[13] A. Minamoto, H. Taniguchi, N. Yoshitani, S. Mukai, T. Yoko- yama, T. Kumagami, Y. Tsuda, H. K. Mishima, T. Amemiya and M. Akahoshi. Cataract in atomic bomb survivors. International Journal of Radiation Biology, 2004, 80(5): 339-345.
[14] M. Otake, W. J. Schull. A review of forty-five years study of Hi- roshima and Nagasaki atomic bomb survivors. Radiation cataract. Journal of Radiation Re-search (Tokyo), 1991, 32: 283-293.
[15] D. A. Pierce, D. L. Preston. Radiation-related cancer risks at low doses among atomic bomb survi-vors. Radiation Research, 2000, 154(2): 178-186.
[16] K. Choshi, I. Takaku, H. Mishima, T. Takase, S. Neriishi, S. Finch and M. Otake. Ophthalmologic changes related to radia- tion exposure and age in Adult Health Study sample, Hiroshima and Nagasaki. Radiation Re-search, 1983, 96(3): 560-579.
[17] M. Otake, S. Finch, K. Choshi, I. Takaku, H. Mishima and T. Takase. Radiation-related ophthalmological changes and aging among Hiroshima and Nagasaki A-bomb survivors: A reanalysis. Radiation Research, 1992, 131(3): 315-324.
[18] A. Minamoto, H. Taniguchi, N. Yoshitani, S. Mukai, T. Yokoyama, T. Kumagami, Y. Tsuda, H. K. Mishima, T. Amemiya and M. Akahoshi. Cataract in atomic bomb survivors. International Journal of Radiation Biology, 2004, 80(5): 339-345.
[19] M. Yamada, F. L. Wong, S. Fuji-wara, M. Akahoshi and G. Suzuki. Noncancer disease incidence in atomic bomb survivors, 1958-1998. Radiation Research, 2004, 161: 622-632.
[20] R. Day, M. B. Gorin and A. W. Eller. Prevalence of lens changes in Ukrainian children residing around Chernobyl. Health Physics, 1995, 68(5): 632-642.
[21] B. V. Worgul, Y. I. Kundiyev, N. M. Sergiyenko, V. V. Chumak, P. M. Vitte, C. Medvedovsky, E. V. Bakhanova, A. K. Junk, O. Y. Kyrychenko and R. E. Shore. Cataracts among Chernobyl clean- up workers, implications regarding permissi-ble eye exposures. Radiation Research, 2007, 167(2): 233-243.
[22] V. V. Chumak, B. V. Worgul, Y. I. Kundiyev, N. M. Sergiyenko, P. M. Vitte, C. Medvedovsky, E. V. Bakhanova, A. K. Junk, O. Y. Kyrychenko and R. E. Shore. Dosimetry for a study of low-dose radia-tion cataracts among Chernobyl clean-up workers. Radiation Research, 2007, 167(5): 606-614.
[23] B. S. Jacobson. Cataracts in retired acti-nide-exposed radiation workers. Radiation Protection Dosimetry, 2005, 113(1): 123- 125.
[24] J. A. Jones, M. McCarten, K. Manuel, B. Djo-jonegoro, J. Murray, A. Feiversen and M. Wear. Cataract formation mechanism and risk in aviation and space crews. Aviation, Space, and Environmental Medicine, 2007, 78(4): A56-A66.
[25] F. A. Cucinotta, F. K. Manuel, J. Jones, G. Iszard, J. Murray, B. Djojonegoro and M. Wear. Space radiation and cataracts in astronauts. Radiation Research, 2001, 156(5): 460-466.
[26] V. Rafnsson, E. Olafsdottir, J. Hrafnkels-son, H. Sasaki, A. Arnarsson and F. Johansson. Cosmic radiation in-creases the risk of nuclear cataract in airline pilots. Archives of Oph-thalmology, 2005, 123(8): 1102-1105.
[27] L. T. Chylack Jr., L. E. Peterson, A. H. Feiveson, M. L. Wear, F. K. Manuel, W. H. Tung, D. S. Hardy, L. J. Marak and F. A. Cucinotta. NASA study of cataract in astronauts (NASCA). Report 1: Cross-sectional study of the relation-ship of exposure to space radiation and risk of lens opacity. Radiation Research, 2009, 172(1): 10-20.
[28] W.-L. Chen, J.-S. Hwang, T.-H. Hu, M.-S. Chen and W. P. Chang, Lenticular opacities in populations ex-posed to chronic low-dose- rate gamma radiation from radio contami-nated buildings in Taiwan. Radiation Research, 2001, 156(1): 71-77.