合成化学研究  >> Vol. 1 No. 1 (September 2013)

盐酸文拉法辛的合成
Synthesis of Venlafaxine Hydrochloride

DOI: 10.12677/SSC.2013.11001, PDF, HTML, 下载: 3,230  浏览: 12,739  科研立项经费支持

作者: 朱园园*, 古双喜*:武汉工程大学化工与制药学院,绿色化工过程教育部重点实验室;李婷婷*:中国科学院武汉水生生物研究所

关键词: 盐酸文拉法辛合成抗抑郁药茴香醇Venlafaxine Hydrochloride; Synthesis; Antidepressant; Anisic Alcohol

摘要: 以廉价易得的茴香醇为原料,经7步反应以56.7%的总收率合成得到盐酸文拉法辛。该路线简捷高效,反应条件温和,后处理操作简单,适合工业化生产。  Venlafaxine hydrochloride was synthesized via 7-step reactions in the total yield of 56.7% from anisic alcohol. The synthetic route is concise and efficient, and suitable for industrialization due to its mild reaction conditions and simple post-treatment.

 

文章引用: 朱园园, 李婷婷, 古双喜. 盐酸文拉法辛的合成[J]. 合成化学研究, 2013, 1(1): 1-3. http://dx.doi.org/10.12677/SSC.2013.11001

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