蛋白去乙酰基酶SIRT1的免疫调节效应及机制
Immunomodulation and Mechanism of Protein Deacetylase SIRT1
DOI: 10.12677/IS.2013.12002, PDF, HTML, 下载: 3,609  浏览: 15,617  国家自然科学基金支持
作者: 张 妍：沈阳农业大学畜牧兽医学院，沈阳；复旦大学上海医学院免疫学系，上海；复旦大学生物治疗中心，上海；张正国, 刘光伟*：复旦大学上海医学院免疫学系，上海；复旦大学生物治疗中心，上海；汉丽梅*：沈阳农业大学畜牧兽医学院，沈阳
关键词: SIRT1；巨噬细胞；T细胞；免疫调节；SIRT1; Macrophages; T Cells; Immune Modulation
摘要:

机体免疫分为天然免疫和适应性免疫，分别由不同的免疫细胞介导。SIRT1 (silent mating type information regulation 2 homolog 1)是一种具有烟酰胺腺嘌呤二核苷酸(Nicotinamide Adenine Dinucleotide, NAD)依赖性的蛋白去乙酰基酶活性的转录调节因子，在细胞寿命和机体代谢中发挥重要作用。近年来，SIRT1在免疫中的调控作用逐渐为研究者所重视。本文仅就SIRT1在天然免疫和适应性免疫中的调控效应及分子机制做一简要综述。 Different kinds of lymphocytes could be involved in the innate immunity and adaptive immunity. Silent mating type information regulation 2 homolog 1 (SIRT1) is a Nicotinamide Adenine Dinucleotide (NAD)-dependent protein deacetylase, which plays a critical role in life span and metabolism. Recently, the immune functional studies of SIRT1 have become a hot spot in immunological field. This review only summarizes the modulation of SIRT1 on both innate immunity and adaptive immunity and its molecular mechanism.

文章引用：张妍, 张正国, 汉丽梅, 刘光伟. 蛋白去乙酰基酶SIRT1的免疫调节效应及机制[J]. 免疫学研究, 2013, 1(2): 7-10. http://dx.doi.org/10.12677/IS.2013.12002

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