摘要:
糖尿病严重威胁着人类的健康，而糖尿病的发生与胰岛功能失调有密切联系。肾素–血管紧张素–醛固酮系统在胰岛表达，并对胰岛功能和胰岛素分泌具有调节作用。其中，血管紧张素II和醛固酮能够抑制胰岛素分泌，而血管紧张素转化酶2活性升高可促进胰岛素分泌。同时，血管紧张素转化酶抑制剂能够预防胰腺的炎症反应及纤维化，抑制胰岛内部的细胞凋亡，进而改善胰岛功能、促进胰岛素分泌。而血管紧张素受体拮抗剂能增加胰腺血流量及预防炎症反应及纤维化，从而促进胰岛素分泌。因此，肾素–血管紧张素–醛固酮系统可能成为糖尿病的治疗靶点。
Diabetes mellitus is a serious threat to human health
and its occurrence is closely related to islet dysfunction. The renin-angiotensin-aldosterone
system is expressed in islets and plays an important role in islet function and
insulin secretion. Angiotensin II and aldosterone can inhibit the secretion of
insulin. Angiotensin-converting enzyme promotes insulin secretion. The angiotensin
converting enzyme inhibitor can improve pancreatic function and insulin
secretion via the amelioration of intra-islets inflammation, fibrosis and
apoptosis. The angiotensin receptor blocker can ameliorate intra-islets
inflammation, fibrosis so as to improve insulin secretion.
Renin-angiotensin-aldosterone system may become a therapeutic target for the
treatment of diabetes.