铁元素与子宫颈癌的关系

Relation of Iron and Cervical Cancer

摘要: 铁是细胞生长的必需元素，肿瘤细胞内铁的含量高于正常细胞。增加外源性的铁元素可以防止细胞凋亡，而铁螯合剂可以抑制肿瘤细胞生长。因此，铁螯合剂在抗肿瘤方面受到日益广泛的关注。近年来研究表明，铁与子宫颈癌细胞的增殖和凋亡有着密切关系，对此，本文探讨了铁元素在子宫颈癌发生中的作用机制及铁螯合剂在治疗宫颈癌方面的作用。

Abstract:  Iron is an essential element for cell growth. The iron contents in tumor cells are higher than those in normal cells. The addition of exogenous iron can prevent apoptosis while iron chelators can inhibit the growth of tumor cells. Therefore, the anti-tumor effect of iron chelators obtains more and more extensive concern. This article aims to present a review on recent advancements in studies of iron and cervical cancer, and to explore the mechanism of iron in initiating cervical cancer as well as the effects of iron chelators on treatment of cervical cancer.