神经干细胞与脑缺血损伤
Neural Stem Cells and Cerebral Ischemia Injury
DOI: 10.12677/ACRVM.2014.31001, PDF, HTML,  被引量 下载: 2,632  浏览: 9,677 
作者: 田兆华:深圳市龙岗区中医院急诊科,深圳;刘柏炎:湖南中医药大学中医内科实验室,长沙
关键词: 神经干细胞脑缺血损伤Neural Stem Cells; Cerebral Ischemia Injury
摘要: 目的:探讨神经干细胞的定义、移植分化及调控因素,以及与脑缺血之间的关系。方法:通过阐述神经干细胞的定义及生物学特性,结合神经干细胞移植及微环境调控,进一步将神经干细胞与脑缺血损伤修复机制加以联系。结果:神经干细胞能够修复脑缺血损伤,但要克服定向分化、炎症及排斥反应等问题。结论:神经干细胞移植可用于脑缺血损伤神经修复。 Objective: To explore the definition, transplantation, differentiation, regulator factors and the relation of neural stem cells (NSCs) and cerebral ischemia injury. Methods: To expound the definition and biological characteristics of NSCs, unite NSCs transplantation, micro environment control and to contact NSCs and cerebral ischemia injury mechanism. Results: Neural stem cells may repair cerebral ischemia injury, but overcome the problem of directional differentiation, inflammation and reject reaction. Conclusion: The transplantation of neural stem cells can be used in the neural restoration of the cerebral ischemia injury.
文章引用:田兆华, 刘柏炎. 神经干细胞与脑缺血损伤[J]. 亚洲心脑血管病例研究, 2014, 3(1): 1-3. http://dx.doi.org/10.12677/ACRVM.2014.31001

参考文献

[1] Hugnot, J.P. (2013) Isolate and culture neural stem cells from the mouse adult spinal cord. Methods in Molecular Biology, 1059, 53-63.
[2] Reynolds, B.A. and Weiss, S. (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science, 255, 1707.
[3] Waldron, J., McCourty, A., Lecanu, L. (2010) Neural stem cell sex dimorphism in aromatase (CYP19) expression: A basis for differential neural fate. Cell Death & Disease, 22, 175-182.
[4] Germano, I., Swiss, V. and Casaccia, P. (2010) Primary brain tumors, neural stem cell, and brain tumor cancer cells: where is the link? Neuropharmacology, 58, 903-910.
[5] De Filippis, L. and Binda, E. (2012) Concise review: Self-renewal in the central nervous system. Neural stem cells from embryo to adult. Stem Cells Translational Medicine, 1, 298-308.
[6] Culley, D.J., Boyd, J.D., Palanisamy, A., et al. (2011) Isoflurane decreases self-renewal capacity of rat cultured neural stem cells. Anesthesiology, 115, 754-763.
[7] Itou, Y., Nochi, R., Kuribayashi, H., et al. (2011) Cholinergic activation of hippocampal neural stem cells in aged dentate gyrus. Hippocampus, 21, 446-459.
[8] Pathipati, P., Gorba, T., Scheepens, A., et al. (2011) Growth hormone and prolactin regulate human neural stem cell regenerative activity. Neuroscience, 8, 409-427.
[9] Kim, H.J., Oh, J.S., An, S.S., et al. (2012) Hypoxia-specific GMCSF-overexpressing neural stem cells improve graft survival and functional recovery in spinal cord injury. Gene Therapy, 19, 513521.
[10] Nam, H.-S. and Benezra, R. (2009) High Levels of Id1 expression define B1 type adult neural stem cells. Cell Stem Cell, 5, 515-526.
[11] Giovanna, M.B. and Daniel, A. (2011) Peterson. Phenotypic and gene expression modification with normal brain aging in gfappositive astrocytes and neural stem cells. Aging Cell, 10, 466482.
[12] Petra, H., Justin, D.L., Rikke, R., et al. (2012) Autocrine VEGFVEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. The Journal of Experimental Medicine, 209, 507-520.
[13] Vangipuram, S.D., Lyman, W.D., et al. (2012) Ethanol affects differentiation-related pathways and suppresses Wnt signaling protein expression in human neural stem cells. Alcoholism: Clinical and Experimental Research, 36, 788-797.
[14] Hayon, Y., Dashevsky, O., Shai, E., et al. (2012) Platelet microparticles promote neural stem cell proliferation, survival and differentiation. Progress in Brain Research, 47, 659-669.
[15] 朱立华, 蔡光先 (2013) 补阳还五汤促脑缺血后中晚期内源性神经再生的蛋白质组研究. 湖南中医杂志, 8, 121-124.
[16] Gutova, M., Shackleford, G.M., Khankaldyyan, V., et al. (2013) Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma. Gene Therapy, 20, 143-150.
[17] 卢健棋, 温志浩, 潘朝锌等 (2013) 补阳还五汤对经皮冠状动脉支架植入术后血管内皮功能的影响. 中西医结合心脑血管病杂志, 11, 3-5.