Rho激酶与缺血性脑血管疾病
Rho Kinases and Ischemic Cerebrovascular Diseases
DOI: 10.12677/PI.2014.31005, PDF, HTML,  被引量 下载: 2,782  浏览: 9,265  国家自然科学基金支持
作者: 林辰雨, 汪 宁:安徽中医药大学药学院中药药理系,合肥;安徽中医药科学院中药药效与安全性评价研究所,合肥;新安医学省部共建教育部重点实验室,合肥
关键词: Rho激酶脑缺血RhoARac 1Rho Kinases; Cerebral Ischemia; RhoA; Rac 1
摘要: Rho激酶(Rho associated kinasesROCK)通过调控脑缺血的发病过程中多条信号通路在脑缺血的发病中发挥着重要作用。本文概述了ROCK在缺血性脑血管疾病中的相关作用,为缺血性脑血管疾病提供相应的理论参考。
Abstract: Rho kinases (Rho associated kinases, ROCK) are involved in various signaling pathways in the pathogenesis of cerebral ischemia. The article outlines the role of ROCK in ischemic cerebrovascular diseases, which provides theoretical reference for ischemic cerebrovascular diseases.
文章引用:林辰雨, 汪宁. Rho激酶与缺血性脑血管疾病[J]. 药物资讯, 2014, 3(1): 19-21. http://dx.doi.org/10.12677/PI.2014.31005

参考文献

[1] Hall, A. (1998) Rho GTPases and the actin cytoskeleton. Science, 279, 509-514.
[2] Nakamura, F. (2013) FilGAP and its close relatives: A mediator of Rho-Rac antagonism that regulates cell morphology and migration. Biochemical Journal, 453, 17-25.
[3] Doran, J.D., Liu, X., Taslimi, P., et al. (2004) New insights into the structure function relationships of Rho associated kinase: A thermodynamic and hydrodynamic study of the dimer to monomer transition and its kinetic implications. Biochemical Journal, 384, 255-262.
[4] Catharine, A. and Bryan, B.A. (2011) Rho kinase proteins— Pleiotropic modulators of cell survival and apoptosis. Anticancer Research, 31, 3645-3657.
[5] Naraoka, M., Munakata, A., Matsuda, N., Shimamura, N. and Ohkuma, H. (2013) Suppression of the Rho/Rho-Kinase pathway and prevention of cerebral vasospasm by combination treatment with statin and fasudil after subarachnoid hemorrhage in rabbit. Translational Stroke Research, 4, 368-374.
[6] Heasman, S.J. and Ridley, A.J. (2008) Mammalian Rho GTPases: New insights into their functions from in vivo studies. Nature Reviews Molecular Cell Biology, 9, 690-701.
[7] Diebold, B.A., Fowler, B., Lu, J., et al. (2004) Antagonistic cross talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species. The Journal of Biological Chemistry, 279, 28136-28142.
[8] Sahai, E. and Marshall, C.J. (2002) Rho-GTPases and cancer. Nature Reviews Cancer, 2, 133-142.
[9] Van Aelst, L. and D’Souza-Schorey, C. (1997) Rho GTPases and signalling networks. Genes & Development, 11, 2295-2322.
[10] Takemoto, M., Sun, J., Hiroki, J., Shimokawa, H. and Liao, J.K. (2002) Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation, 106, 57-62.
[11] Joshi, A.D., Dimitropoulou, C., Thangjam, G., Snead, C. and Feldman, S. (2013) Hsp90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling. American Journal of Respiratory Cell and Molecular Biology, 23, 4553.
[12] Lees, K.R., Diener, H.C., Asplund, K., et al. (2003) UK 279, 276, a neutrophil inhibitory glycoprotein, in acute stroke: Tolerability and pharmacokinetics. Stroke, 34, 1704-1709.
[13] Shi, J. and Wei, L. (2007) Rho kinase in the regulation of cell death and survival. Archivum Immunologiae et Therapia Experimentalis, 55, 61-75.
[14] Shin, H.K., Salomone, S., Potts, E.M., et al. (2007) Rhokinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms. Journal of Cerebral Blood Flow & Metabolism, 27, 998-1009.
[15] Shibuya, M., Hirai, S., Seto, M., et al. (2005) Effects of fasudil in acute ischemic stroke: Results of a prospective placebo controlled double blind trial. Journal of the Neurological Sciences, 15, 31-39.
[16] Wang, S., Lee, S.R., Guo, S.Z., et al. (2006) Reduction of tissue plasminogen activator induced matrix metalloproteinase9 by simvastatin in astrocytes. Stroke, 37, 1910-1912.
[17] Rikitake, Y., Kim, H.H., Huang, Z., et al. (2005) Inhibition of Rhokinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke, 36, 2251-2257.
[18] 刘康, 丁素菊, 吴涛, 等 (2011) Rho激酶抑制剂对大鼠脑缺血损伤的脑保护作用及S100B蛋白表达的影响. 临床神经病学杂志, 2, 111-113.