儿童急性淋巴细胞白血病并发巨细胞病毒性视网膜炎一例并文献复习
Case Report of a Child with Acute Lymphoblastic Leukemia Complicated with CMV Retinitis and the Literature Review
DOI: 10.12677/ACRP.2014.21001, PDF, HTML, 下载: 2,952  浏览: 11,731 
作者: 赵贝贝, 林 强, 郭爱连, 何海龙：苏州大学附属儿童医院血液科，苏州
关键词: 巨细胞病毒性视网膜炎；急性淋巴细胞性白血病；儿童；Cytomegalovirus Retinitis; Acute Lymphoblastic Leukemia; Child
摘要:  巨细胞病毒性视网膜炎(Cytomegalovirus Retinitis)以“比萨饼样”眼底改变为特征，是免疫缺陷患者的机会性感染之一，考虑人类免疫缺陷病毒感染或获得性免疫缺陷综合征，全身应用免疫抑制剂及化疗药物所致。常发生在艾滋病患者中，而在儿童急性淋巴细胞性白血病患儿中却少见。本文报道儿童急性淋巴细胞白血病并发巨细胞病毒性视网膜炎一例，并对巨细胞病毒性视网膜炎相关文献进行复习，进一步让临床医师了解这类疾病。
Abstract:  CMV Retinitis (Cytomegalovirus Retinitis), which is characterized by “pizza” fundus change, is one of the opportunistic infection of immunocompromised patients, caused by systemic application of immunosuppressant and chemotherapy drugs considering human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome. CMV retinitis often occurs in AIDS patients while it is rare in children with acute lymphocytic leukemia. This paper reported a case of a child with acute lymphoblastic leukemia complicated with CMV retinitis and reviewed the related literature of CMV retinitis to make a further understanding of this kind of disease for clinicians.
文章引用：赵贝贝, 林强, 郭爱连, 何海龙. 儿童急性淋巴细胞白血病并发巨细胞病毒性视网膜炎一例并文献复习[J]. 亚洲儿科病例研究, 2014, 2(1): 1-5. http://dx.doi.org/10.12677/ACRP.2014.21001

参考文献

[1] 李凤鸣 (1996) 眼科全书. 卫生出版社, 北京, 3552-3568.
[2] Egbert, P.R., Pollard, R.B., Gallagher, J.G., et al. (1980) Cytomegelovirus retinitis in immunosuppressed hosts: Òocular manifestation. Annals of Internal Medicine, 93, 664.
[3] Xhaard, A., et al. (2007) Increased incidence of cytomegalovirus retinitis after allogeneic hematopoietic stem cell transplantation. Transplantation, 83, 80-83.
[4] 董永绥, 方峰, 张明 (1995) 巨细胞病毒感染诊断试行标准. 中华儿科杂志, 1, 8.
[5] Kobayashi, R. (2012) Retinitis from cytomegalovirus during maintenance treatment for acute lymphoblastic leukemia. Pediatrics International, 54, 288-290.
[6] Moritake, H. (2013) Cytomegalovirus retinitis as an adverse immunological effect of pulses of vincristine and dexamethasone in maintenance therapy for childhood acute, lymphoblastic leukemia. Pediatric Blood & Cancer, 60, 329-331.
[7] Wakai, K., et al. (2013) Cytomegalovirus retinitis during maintenance therapy for T-cell acute lymphoblastic leukemia. Journal of Pediatric Hematology/Oncology, 35, 162-163.
[8] Singh, R. (2013) Cytomegalovirus retinitis in an ALL child on exclusive che-motherapy treated successfully with intravitreal ganciclovir alone. Journal of Pediatric Hematology/Oncology, 35, e118-e119.
[9] Urakami, T., et al. (2002) Successful treatment of cytomegalovirus retinitis in a child with acute lymphoblastic leukemia during maintenance chemotherapy. The Japanese Journal of Pediatric Hematology, 16, 312-316.
[10] EI-Chennawi, F.A., et al. (2008) Immune reconstitution during maintenance therapy in children with acute lymphoblastic leukemia. Hematology, 13, 203-209.
[11] Pertel, P., et al. (1992) Risk of developing cytomegalovirus retinitis in persons infected with the human immunodeficiency virus. Journal of Acquired Immune Deficiency Syndromes, 5, 1069-1074.
[12] Gallant, J.E., et al. (1992) Incidence and natural history of cytomegalovirus disease in patients with zidovudine. The ZidovuDine Study Group. The Journal of Infectious Diseases, 166, 1223-1227.
[13] Fornara, O. (2013) Human cytomegalovirus particles directly suppress CD4 T-lymphocyte activation and proliferation. Immunobiology, 218, 1034-1040.
[14] 徐戎, 等 (2005) 食物对口服更昔洛韦人体内吸收的影响. 中国药学杂志, 17, 1327-1330.
[15] Emery, V.C. and Hassan-Walker, A.F. (2002) Focus on new drugs in development against human cytomegalovirus. Drugs, 62, 1853-1858.
[16] Henkin, C.C., Griener, J.C. and Ten Eick, A.P. (2003) Stability of valganciclovir in extemporaneously compound liquid formulations. American Journal of Health-System Pharmacy, 60, 687690.
[17] Ohta, H., Matsuda, Y., Tokimasa, S., Sawada, A., Kim, J.Y., Sashihara, J., et al. (2001) Foscarnet therapy for ganciclovir-resistant cytomegalovirus retinitis after stem cell transplantation: Effective monitoring of CMV infection by quantitative analysis of CMV mRNA. Bone Marrow Transplant, 27, 1141-1145.
[18] 易红, 李卓荣 (2005) 抗病毒药物西多福韦. 食品与药品, 10, 15-18.
[19] 陶佩珍 (2003) 抗疱疹病毒药物研究进展. 中国新药杂志, 4, 253-257.
[20] Perry, C.M. and Barman Balfour, J.A. (1999) Fomivirsen. Drug, 57, 375-381.
[21] Vitravene Study Group (2002) Safty of intravitreas fomivirsen for treatment of cytomegalovirus retinitis in patients with AIDS. American Journal of Ophthalmology, 133, 484-498.
[22] 袁慧, 闻良珍, 刘世新, 李丹 (2005) 中药金叶败毒制剂抗人巨细胞病毒感染的作用机制研究. 中国优生与遗传杂志, 4, 27-28, 55.
[23] 姜宏, 闻良珍, 凌霞珍 (2005) 中药热毒清对人巨细胞病毒抑制作用的实验与临床研究. 中国新药与临床杂志, 10, 769-773.
[24] 袁少英, 唐文志, 周件贵, 黄志洪, 廖春盛 (2004) 解毒胶囊0治疗人巨细胞病毒活动性感染36例临床观察. 江苏中医药, 3, 27-28.
[25] 吴祥元, 董敏, 张平, 肖若之, 林曲, 林东军, 等 (2002) 更昔洛韦联合大剂量丙种球蛋白治疗巨细胞病毒感染. 中华医院感染学杂志, 6, 469-470.
[26] 胡毅文, 袁静, 杨桂林, 王辉, 刘艳, 周伯平, 等 (2005) HAART联合白介素-2促进AIDS免疫重建的研究. 中国艾滋病性病, 11, 406-408, 414.
[27] Davis, J.L., Hummer, J. and Feuer, W.J. (1998) Laser photocoagulation for retinal detachments and retinal tears in cytomegalovirus retinitis. Ophthalmology, 105, 1353-1355.
[28] Wohl, D.A., Kendall, M.A., Owens, S., Holland, G., Nokta, M., Spector, S.A., et al. (2005) The safty of discontinuation of maintenance therapy for cytomegalovirus retinitis and incidence of immune recovery uveitis following potent antiretroviral therapy. HIV Clinical Trials, 6, 136-146.
[29] Gerna, G., Piccinini, G., Genini, E., Percivalle, E., Zavattoni, M., Lilleri, D., et al. (2001) Declining levels of rescued lympho proliferative response to human cytomegalovirus (HCMV) in AIDS patients with or without HCMV disease following long-term HAART. Journal of Acquired Immune Deficiency Syndromes, 28, 320-321.
[30] Libby, E. (2010) Cytomegalovirus retinitis during chemotherapy with rituximab plus hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone. Journal of Clinical Oncology, 28, e661-e662.
[31] 何太雯, 等 (2008) 巨细胞病毒性视网膜炎的治疗进展. 眼科新进展, 3, 234-237.