WJCR  >> Vol. 4 No. 2 (April 2014)

    青年结直肠癌的临床病理特点分析
    Clinical and Pathological Characteristics of Colorectal Cancer in Young Patients

  • 全文下载: PDF(452KB) HTML    PP.28-32   DOI: 10.12677/WJCR.2014.42006  
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作者:  

杨 磊,欧阳书睿,张思琴,郭 睿,林峰洋,魏 佳,贾洪源,刘 莹,曾彦彰,迟冬梅:四川大学华西临床医学院,成都;
杨 烈,于永扬,周总光:四川大学华西医院胃肠外科,成都

关键词:
结直肠癌临床病理特点年龄因素青年患者Colorectal Cancer; Age; Pathological Characteristics; Young Patients

摘要:

目的:分析我国青年结直肠癌(colorectal cancer, CRC)患者的临床病理特点。方法:回顾性分析136例CRC,以年龄为界分为3组:青年组(年龄 ≤ 40岁)、中年组(年龄:40~60岁)和老年组(年龄 > 60岁),比较分析青年结直肠癌的临床病理特点,包括患者是否有合并症、肿瘤位置、TNM分期、病理类型和分化程度等。结果 青年、中年及老年组患者合并基础疾病发生率分别为59.0%、18.7%和8.2%,有统计学差异(P < 0.05)。肿瘤TNM分期中,中、老年患者肿瘤T4分期显著高于青年组(P < 0.05),分别为52.1%、64.1%和20.4%。青年患者组肿瘤N2期所占比例高于中、老年组(P < 0.05),分别为22.5%、16.6%和5.1%。三组患者的总TNM分期、肿瘤位置、TNM分期、病理类型和分化程度等并无统计学差异。结论:青年结直肠癌患者肿瘤T4分期较少,而肿瘤淋巴结转移率高,提示青年结直肠癌患者肿瘤更易于淋巴结转移。

 Objective: Analysis of clinical and pathological characteristics of colorectal cancer in young patients. Methods: A retrospective analysis of 136 cases of CRC, which was divided by age into three groups: young group (age ≤ 40 years), middle-aged group (age: 40 to 60 years) and older group (age > 60 years). Compare the differences of clinical and pathological characteristics among them, including whether the patient has complications, tumor location, TNM stage, histological type, degree of differentiation and depth of invasion. Results: Patients with basic disease incidence were 59.0% in older group, 18.7% in middle-aged group and 8.2% in young group, a significant difference (P < 0.05). Elderly patients with T4 tumor staging were more than young group (P < 0.05), and the proportion respectively is 52.1% in middle-aged group, 64.1% in older group and 20.4% in young group. In N stage, the young group was higher than the others in the proportion of N2 stage, a significant difference (P < 0.05), and the proportion respectively is 22.5%, 16.6% and 5.1%. Conclusion: In TNM stage system, young patients in T4 stage are fewer, but the lymph node metastasis rate is higher, suggesting that CRC in young patients is easier to lymph node metastasis.

文章引用:
杨磊, 欧阳书睿, 张思琴, 郭睿, 林峰洋, 魏佳, 贾洪源, 刘莹, 曾彦彰, 迟冬梅, 杨烈, 于永扬, 周总光. 青年结直肠癌的临床病理特点分析[J]. 世界肿瘤研究, 2014, 4(2): 28-32. http://dx.doi.org/10.12677/WJCR.2014.42006

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