ACRP  >> Vol. 2 No. 3 (August 2014)

    Vitamin D Supplementation Improves Autistic Symptoms in a Child with Autism Spectrum Disorder

  • 全文下载: PDF(290KB) HTML    PP.21-24   DOI: 10.12677/ACRP.2014.23005  
  • 下载量: 2,160  浏览量: 7,247  



孤独症谱系障碍维生素D儿童环境因素Autism Spectrum Disorders Vitamin D Children Environmental Factor


目的:近年来,研究发现维生素D不足和缺乏是引起孤独症谱系障碍的环境因素之一,本研究目的在于探讨补充维生素D治疗儿童孤独症谱系障碍的可能性。方法:对我科应用维生素D治疗的1例孤独症谱系障碍的临床资料进行了回顾性分析。结果:患儿因言语发育落后和不听指令来我科就诊,结合患儿的临床症状,根据DSM-IV标准,该患儿确诊为孤独症谱系障碍。ABC,CARS和M-CHAT-R量表用来评估患儿症状的严重程度。血清25(OH)D水平为14.3 ng/ml。给予患儿维生素D肌肉注射和口服共两个月,患儿临床症状好转,疾病严重程度减轻,血清25(OH)D水平升至51.8 ng/ml。结论:补充维生素D有可能改善孤独症谱系障碍患儿的临床症状。

Objective: Vitamin D insufficiency and deficiency is recently regarded as one of the environmental factors related with autism spectrum disorders. The aim of this paper is to investigate the possible effect of vitamin D supplementation on autistic behavioral manifestations of a child with autism spectrum disorders. Methods: The clinical data of one case with autism spectrum disorders with vitamin D supplementation in our department was retrospectively analyzed. Result: The child was referred to our department for language delay and unresponsivity to instruction. In view of his clinical manifestation, diagnosis of autism spectrum disorders was made according to DSM-IV. ABC, CARS and M-CHAT-R were used to assess the autistic severity in the clinic. Serum 25(OH) level was 14.3 ng/ml. Vitamin D3 intramuscular injection and oral administration were carried out according to protocol of our clinical trial registration. With a two-month following-up, the autistic symptoms were gradually improved according to clinical manifestation and assessment batteries. Meanwhile, Serum 25(OH) level was 51.8 ng/ml. Conclusion: Vitamin D supplementation may be effective in ameliorating the autistic behavioral problems in children with autism spectrum disorders.

贾飞勇, 王冰, 单玲, 徐志达, 冯俊燕, 杜琳. 维生素D改善孤独症谱系障碍患儿行为[J]. 亚洲儿科病例研究, 2014, 2(3): 21-24.


[1] Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators, Centers for Disease Control and Prevention (CDC) (2012) Prevalence of autism spectrum disorders-autism and developmental disabilities monitoring network, 14 sites, United States, 2008. MMWR Surveillance Summaries, SS03, 1-19.
[2] 段小燕, 贾飞勇, 姜慧轶 (2013) 维生素D与孤独症谱系障碍的关系. 中国当代儿科杂志, 8, 698-702.
[3] Morse, N.L. (2012) Benefits of docosahexaenoic acid, folic acid, vitamin D and iodine on foetal and infant brain development and function following maternal supplementation during pregnancy and lactation. Nutrients, 7, 799-840.
[4] Burne, T.H., McGrath, J.J., Eyles, D.W., et al. (2005) Behavioural characterization of vitamin D receptor knockout mice. Behavioural Brain Research, 2, 299-308.
[5] 李洪华, 姜慧轶, 杜琳, 等 (2012) 儿童孤独症的早期筛查与诊断研究进展. 中国实验诊断学, 11, 2147-2150.
[6] Politte, L.C., Henry, C.A., McDougle, C.J. (2014) Psychopharmacological interventions in autism spectrum disorder. Harvard Review of Psychiatry, 2, 76-92.
[7] Preti, A., Melis, M., Siddi, S., et al. (2014) Oxytocin and autism: A systematic review of randomized controlled trials. Journal of Child and Adolescent Psychopharmacology, 2, 54-68.
[8] Miller, M., Bales, K.L., Taylor, S.L., et al. (2013) Oxytocin and vasopressin in children and adolescents with autism spectrum disorders: Sex differences and associations with symptoms. Autism Research, 2, 91-102.