药物渴求的神经生物学基础及分子机制研究进展
Progress in Study on the Foundation of the Neuro-Biology and the Molecule-Mechanisms for Drug Craving
DOI: 10.12677/PI.2014.33009, PDF,   
作者: 潘乐鸯：内蒙古医科大学药学院，呼和浩特
关键词: 药物渴求；神经药理；分子机制；个体因素；Drug Craving； Neuropharmacology； Molecular Mechanisms； Individual Factor
摘要: 近年来，药物渴求引起科研学者的广泛关注，对于药物渴求行为的机制研究不断推进并在实验的基础上取得了一些新知识的获得。本文综述了近年来由科研实验证实的参与药物渴求的神经生理学基础、分子和细胞机制等方面的研究进展以及药物滥用者所处的环境对药物渴求的影响。了解药物渴求的神经生理基础及分子水平的生物学程序有助于阐述人类对成瘾性药物的复吸及依赖行为，以期为控制精神类药物滥用提供参考。
Abstract: Drug craving is widely investigated in recent years, the studies on the mechanisms of drug craving have always been advancing and we have got lots of knowledge about it based on the laboratory animal-experiment. In this review, we discuss recent results that have identified for the foundation of the neuro-biology and the molecule-mechanisms for drug craving: the main brain regions involved in the incubation of drug craving, and the evidence for the underlying cellular mechanisms as well as the influence of the exposure to environmental enrichment (EE) during withdrawal periods for individuals. Understanding the neurobiology of the incubation of drug craving is likely to have significant implications for furthering understanding of relapse or addicts in human, this will be beneficial for the control of drug abuse.
文章引用：潘乐鸯. 药物渴求的神经生物学基础及分子机制研究进展[J]. 药物资讯, 2014, 3(3): 38-41. http://dx.doi.org/10.12677/PI.2014.33009

参考文献

[1] 刘闯, 郑继旺 (1999) 药物渴求. 中国药物依赖性杂志, 1, 8.
[2] Childress, A.R., McLellan, A.T. and O’Bdert, C.P. (1986) Conditioned responses in a methadone population: A comparison oflaboratory, clinic, and natural settings. Journal of Substance Abuse Treatment, 3, 173-179.
[3] 梁建辉, 刘锐克 (2001) 药物渴求对复吸行为的始动作用. 中国药物滥用防治杂志, 4, 176.
[4] 俞朝阳 (2005) 脑内组胺、多巴胺能神经在吗啡诱导的条件位置偏爱实验中的作用. 中国药理学通报, 9, 1049-1053.
[5] 余化霖, 叶雯睿, 马以骝 (2006) 多巴胺D2受体拮抗剂、激动剂对SD大鼠条件化位置偏好的影响. 动物学研究, 1, 54-62.
[6] 杨开军, 漆松涛, 王克万 (2005) 伏隔核毁损术治疗阿片类药物精神依赖的初步临床报告. 中国微侵袭神经外科杂志, 2, 69-74.
[7] 秦广彪, 马羽, 张伟 (2009) 药物成瘾机制与治疗的研究进展. 中国康复理论与实践, 12, 1144-1146.
[8] 张开镐 (2002) 药物成瘾的病理生理学基础. 中国药物依赖性杂志, 2, 81-85.
[9] Pickens, C.L., Airavaara, M., Theberge, F. and Fanous, S. (2011) Neurobiology of the incubation of drug craving. Trends in Neurosciences, 34, 411-420.
[10] 陈理宣 (2007) 戒毒者复吸的根本原因及综合治疗模式的构想. 医学与哲学(人文社会医学版), 6, 25-27.
[11] Chauvet, C., Goldberg, S.R., Jaber, M. and Jaber, M. (2012) Effects of environmental enrichment on the incubation of cocaine craving. Neuropharmacology, 63, 635-641.
[12] 陈为升, 刘芳, 周琼 (2004) 药物成瘾的机制. 中国药物滥用防治杂志, 5.