摘要:
前列腺肿瘤(prostate cancer, PCa)作为常见的老年男性肿瘤疾病，发病率正在逐年上升，细胞连接蛋白(Connexon, Cx)的表达异常是其发生机制之一。研究表明前列腺肿瘤细胞较前列腺上皮表达Cx43明显降低，存在细胞间隙连接通讯(GJIC)缺陷，故Cx43表达缺陷可能在前列腺肿瘤发生发展过程中发挥一定作用。研究发现茶多酚类物质，含硒类物质、激素类物质、维生素类、生物碱类等多种化学物质都对前列腺肿瘤细胞Cx43的表达有影响，进而影响前列腺肿瘤发展状况，故本文将对多种化学因素对前列腺肿瘤细胞连接蛋白Cx43的影响及治疗意义作一综述。
Abstract:
Prostate cancer is a common cancer disease within older male populations and its incidence rate increased year by year. The abnormal exception of connexon is one of its pathogenesis. Researches show that Cx43 expression in prostate cancer was effectively lower compared with prostate epi-thelial, what’s more, there existed a gap junctional intercellular communication defects in prostate cancer. So, Cx43 expression defects may significantly affect the prostate cancer process. Researches also show that tea polyphenols substances, selenium substances, hormone-like substances, vitamins, alkaloids, and other chemical substances are also have different levels of effects on the expression of Cx43 in prostate tumor cells. Therefore, they also influenced the development of prostate cancer. So, the following article will mainly state the effecting of variety chemical factors on Cx43 in prostate cancer cells and therapeutic implications.