PI  >> Vol. 4 No. 2 (May 2015)

    肾茶功效相关药理作用研究进展
    Progress in Related Pharmacological Research on Function of Clerodendranthus spicatus

  • 全文下载: PDF(437KB) HTML    PP.23-30   DOI: 10.12677/PI.2015.42003  
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作者:  

陈 珠,杨彩霞,毛晓健:云南中医学院,云南 昆明

关键词:
肾茶药理作用研究进展Clerodendranthus spicatus Pharmacological Effect Research Progress

摘要:

肾茶为肾茶属唇形科多年生草本植物,全草入药,在民间多用于泌尿系统及多种疾病的治疗,疗效确切、毒性小、使用安全且较易栽培,有清热去湿,排石利尿的功效。本文就其功效相关的药理作用研究进展进行综述。结果认为:肾茶在抗炎、利尿、抑菌、健肾、抗高血糖、抗痛风、降压、抗肿瘤、提高机体免疫力等多方面均有广阔的发展前景;目前,复方肾茶作为保健饮料的开发和利用在国内外尚属起步。

Clerodendranthus spicatus (thunb.) C. Y. Wu ex H. W. Li is a traditional folk medicine, whole plant medicine, which is mainly used for the treatment of the urinary system and a variety of effective, outstanding curative effects, less toxic, safe to use and easier cultivation. Orthosiphon can not only clear heat and expel damp but also expel stone and diuresis. This paper reviewed the research progress related to the pharmacological effect on its efficacy. The results indicate that: orthosiphon has a broad prospect for the development of anti-inflammation, diuresis, antibiosis, renal function improvement, anti-hyperglycemia, anti-gout, pressure release, anti-tumors and immunity improvement. Currently, the development and the utilization of orthosiphon compound as a health care beverage have just begun in domestic and abroad.

文章引用:
陈珠, 杨彩霞, 毛晓健. 肾茶功效相关药理作用研究进展[J]. 药物资讯, 2015, 4(2): 23-30. http://dx.doi.org/10.12677/PI.2015.42003

参考文献

[1] 南京中医药大学 (2006) 中药大辞典. 上海科学技术出版社, 上海, 3081-3082.
[2] 国家中医药管理局 (1999) 中华本草(傣药卷). 上海科学出版社, 上海, 155-156.
[3] Zou, J., Zhu, Y.D. and Zhao, W.M. (2008) Two new alkyl glycosides from Cleroden-dranthus spicatus. Journal of Asian Natural Products Research, 10, 603-607.
[4] 侯志勇, 王立强, 梁振生 (2011) 肾茶提取物药理作用的最新研究进展. 中国医药科学, 2, 26-30.
[5] 张建军, 杨琦, 王淳, 等 (2013) 分清肾茶片对角叉菜胶致大鼠前列腺炎的治疗作用及对肿瘤坏死因子-a、前列腺素E2的影响. 中华中医药杂志, 10, 2909-2913.
[6] 肖伟, 刘勇, 高南南, 等 (2009) 肾茶的研究与开发新进展. 中医药现代化, 3, 434-438.
[7] 甘典辉, 唐爱存, 伍小燕, 等 (2013) 肾茶总黄酮对大鼠慢性非细菌性前列腺炎的影响. 中国实验方剂学杂志, 8, 266-268.
[8] 夏立营, 刘维佳, 李明喜, 等 (2014) 苦豆肾茶方对免疫性前列腺炎模型大鼠ICAM-1, INF-γ, MCP-1的影响. 中国中药杂志, 10, 1918-1920.
[9] 黄幼霞, 黄荣桂, 郑兴中 (2011) 迷迭香酸对大鼠肾草酸钙结石形成的影响. 中国医院药学杂志, 14, 1196-1199.
[10] Zhong, Y.S., Yu, C.H., Ying, H.Z., et al. (2012) Prophylactic effects of Orthosiphon stamineus Benth.extracts on exper imental induction of calcium oxalate nephrolithiasis in rats. Journal of Ethnopharmacology, 144, 761-767.
[11] 任文辉, 洪俪芳 (2013) 猫须草的药理作用研究进展. 中草药, 20, 2946-2950.
[12] Rodgers, A.L., Webber, D., Ramsout, R. and Gohel, M.D. (2014) Herbal preparations affect the kinetic factors of calcium oxalate crystallization in synthetic urine: Implications for kidney stone therapy. Urolithiasis, 42, 221-225.
[13] 张新娟, 左国营, 张云玲, 王根春, 韩峻 (2012) 20种滇东南中草药体外抗菌活性筛选. 解放军药学学报, 6, 481- 486.
[14] 徐福春, 罗布占堆, 杨东娟 (2010) 肾茶水浸液抑菌作用研究. 西藏大学学报, 5, 82-85.
[15] 易富, 何宇佳, 梁凯, 王竹琼 (2013) 肾茶水提取物的体外抑菌实验. 西南国防医药, 10, 1058-1059.
[16] Alshawsh, M.A., Abdulla, M.A., Ismail, S., Amin, Z.A., Qader, S.W., Hadi, H.A. and Harmal, N.S. (2012) Free radical scavenging, antimicrobial and immunomodulatory activities of Orthosiphon stamineus. Molecules, 17, 5385-5395.
[17] 王立强, 孟萍萍, 智利, 韩静, 郭晶 (2011) 肾茶提取物防治大鼠慢性肾功能衰竭的实验研究. 中国医药科学, 1, 33-35.
[18] 谢丽萍, 蓝芳, 向彩春, 史伟, 谢永祥, 陶志虎 (2013) 肾茶治疗慢性肾小球肾炎63例临床观察. 广西中医药, 5, 29-31.
[19] Dolečková, I., Rárová, L., Grúz, J., Vondrusová, M., Strnad, M. and Kryštof, V. (2012) Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves. Fitoterapia, 83, 1000-1007.
[20] Al-Suede, F.S.R., Ahamed, M.B.K., Majid, A.S.A., Baharetha, H.M., Hassan, L.E.A., Kadir, M.O.A., et al. (2014) Optimization of cat’s Whiskers Tea (Orthosiphon stamineus) using supercritical carbon dioxide and selective chemotherapeutic potential against prostate cancer cells. Evidence-Based Complementary and Alternative Medicine, 2014, Article ID: 396016.
[21] Yam, M.F., Lim, C.P., Ang, L.F., Por, L.Y., Wong, S.T., Asmawi, M.Z., et al. (2013) Antioxidant and toxicity studies of 50% methanolic extract of Orthosiphon stamineus Benth. BioMed Research International, 2013, Article ID: 351602.
[22] Mohamed, E.A., Siddiqui, M.J., Ang, L.F., Sadikun, A., Chan, S.H., Tan, S.C., et al. (2012) Potent %-glucosidase and %-amylase inhibitory activities of standardized 50% ethanolic extracts and sinensetin from Orthosiphon stamineus Benth as anti-diabetic mechanism. BMC Complementary and Alternative Medicine, 12, 176.
[23] Mohamed, E.A., Yam, M.F., Ang, L.F., Mohamed, A.J. and Asmawi, M.Z. (2013) Antidiabetic properties and mechanism of action of Orthosiphon stamineus Benth bioactive sub-fraction in streptozotocin-induced diabetic rats. Jour- nal of Acupuncture and Meridian Studies, 6, 31-40.
[24] 李光, 陈曦, 路娟, 李学兰, 李宜航 (2013) 肾茶水提物喷干粉对链脲霉素所致糖尿病大鼠降血糖作用机制研究. 中华中医药杂志, 12, 3653-3656.
[25] Ching, M.S., Zakaria, Z.A., Paimin, F., et al. (2013) Complementary alternative medicine use among patients with type 2 diabetes mellitus in the primary care setting: A cross-sectional study in Malaysia. BMC Complementary and Alternative Medicine, 13, 148.
[26] Manshor, N.M., Dewa, A., Asmawi, M.Z., Ismail, Z., Razali, N. and Hassan, Z. (2013) Vascular reactivity concerning Orthosiphon stamineus Benth-mediated antihypertensive in aortic rings of spontaneously hypertensive rats. International Journal of Vascular Medicine, 2013, Article ID: 456852.
[27] Trimarco, V., Cimmino, C.S., Santoro, M., Pagnano, G., Manzi, M.V., Piglia, A., et al. (2012) Nutraceuticals for blood pressure control in patients with high-normal or grade 1 hypertension. High Blood Pressure & Cardiovascular Prevention, 19, 117-122.
[28] 宋伟杰, 王立强, 王之, 孟萍萍 (2011) 肾茶提取物对实验动物循环系统药理作用的研究. 中国医药科学, 7, 47- 53.
[29] Kong, C., Tan, M.-W. and Nathan, S. (2014) Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation. Biology Open, 3, 644-655.
[30] Alshawsh, M.A., Abdulla, M.A., Ismail, S. and Amin, Z.A. (2011) Hepatoprotective effects of Orthosiphon stamineus extract on thioacetamide-induced liver cirrhosis in rats. Evidence-Based Complementary and Alternative Medicine, 2011, Article ID: 103039.
[31] Yam, M.F., Ang, L.F., Salman, I.M., Ameer, O.Z., Lim, V., Ong, L.M., et al. (2009) Orthosiphon stamineus leaf extract protects against ethanol-induced gastropathy in rats. Journal of Medicinal Food, 12, 1089-1097.
[32] Choi, Y.J., Park, S.Y., Kim, J.Y., Won, K.C., Kim, B.R., Son, J.K., et al. (2013) Combined treatment of betulinic acid, a PTP1B inhibitor, with Orthosiphon stamineus extract decreases body weight in high-fat-fed mice. Journal of Medicinal Food, 16, 2-8.
[33] Vogelgesang, B., Abdul-Malak, N., Reymermier, C., Altobelli, C. and Saget, J. (2011) On the effects of a plant extract of Orthosiphon stamineus on sebum-related skin imperfections. International Journal of Cosmetic Science, 33, 44-52.
[34] 罗格莲, 孟萍萍, 王之, 等 (2011) 肾茶提取物对实验动物神经系统药理作用的研究. 中国医药科学, 6, 39- 40.
[35] 王立强, 郭晶, 孟萍萍, 马竑 (2011) 肾茶胶囊的急性毒性实验研究. 中国医药科学, 11, 33-40.
[36] 侯志勇, 王立强, 韩静 (2011) 肾茶胶囊对大鼠脏器长期毒性的实验研究. 中国医药科学, 12, 16-17.
[37] 柳丹萍, 黄荣桂 (2013) 肾茶研究新进展. 海峡药学, 11, 56-60.