JPS  >> Vol. 3 No. 2 (May 2015)

    Influence of Liver and Renal Function in Systemic Mild Hypothermia Technique to the Multiple Organ Dysfunction Syndrome in Children

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罗菲菲,李小双,解启莲,刘利,孙静敏,张美英,吴斌:安徽省儿童医院急救中心,安徽 合肥

多器官功能障碍综合征亚低温儿童肝肾功能Multiple Organ Dysfunction Syndrome Mild Hypothermia Children Liver and Renal Functions


目的:通过全身亚低温治疗多器官功能障碍综合征(MODS)患儿,探讨全身亚低温技术对MODS患儿肝肾功能的影响。方法:将36例患儿随机分为全身亚低温治疗组(亚低温组,HT组,19例)和常规治疗组(对照组,NT组,17例)。分别于亚低温治疗前及治疗后第12 h、24 h、36 h时间点采集外周静脉血检测并记录两组患儿肝肾功能的变化。结果:HT组与NT组治疗前丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)比较无统计学差异(P > 0.05);治疗后36 h ALT两组相比差异具有统计学意义(P < 0.05),且HT组明显优于NT组;治疗后36 h AST相比两组差异无统计学意义(P > 0.05)。HT组与NT组治疗前肌酐(CR)、尿素氮(BUN)比较无统计学差异(P > 0.05);治疗后36 h两组CR、BUN相比差异具有统计学意义(P < 0.05),且HT组明显优于NT组。结论:全身亚低温治疗对MODS患儿肝肾功能具有保护作用。

Objective: By observing systemic mild hypothermia technology in the multiple organ dysfunction syndrome (MODS) in children in the application, to investigate the effects of systemic mild hypo-thermia technology on liver and renal functions of MODS children. Methods: 36 cases of hospita-lized children MODS patients were randomly divided into systemic hypothermia group (HT) 19 patients and the control group (NT) 17 patients. The changes of liver and renal functions of the patients in each group were checked and recorded before and after 12 h, 24 h and 36 h periods in the low temperature. Results: There was no difference in the comparation of ALT, AST, CR and BUN in each time period between two groups (P > 0.05); the level of ALT, CR and BUN in 36 h had obvious statistical difference comparing to the before (P < 0.05), and the HT group than normal temperature NT group; while no significant difference compared to AST in 36 h. Conclusion: The systemic mild hypothermia had significant liver and renal function-protective effects in MODS children patients.

罗菲菲, 李小双, 解启莲, 刘利, 孙静敏, 张美英, 吴斌. 全身亚低温技术对多器官功能障碍综合征患儿肝肾功能的影响[J]. 生理学研究, 2015, 3(2): 9-14.


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