国际神经精神科学杂志  >> Vol. 4 No. 4 (November 2015)

血浆脑钠肽水平对急性脑出血患者转归的预测价值
Prognostic Value of Plasma Brain Natriuretic Peptide Levels in Patients with Acute Intracerebral Hemorrhage

DOI: 10.12677/IJPN.2015.44005, PDF, HTML, XML, 下载: 1,643  浏览: 5,372  国家自然科学基金支持

作者: 韦道明, 朱雪红:中国人民解放军八五医院神经内分泌科单位,上海;高丽丽, 杨瑞玲, 林菊珊, 李世举, 吴成翰*:福建中医院大学附属第二人民医院神经内科,福建 福州

关键词: 脑出血脑钠肽预后Cerebral Hemorrhage Brain Natriuretic Peptide Prognosis

摘要: 目的:探讨血浆脑钠肽(BNP)水平与脑出血患者预后的关系。方法:回顾性分析2010年12月~2013年12月治疗的109例脑出血患者,根据转归分为转归良好组和转归不良组。采用酶联免疫吸附法(ELISA)测定血浆BNP。结果:患者卒中病史、吸烟史、血肿体积、格拉斯哥昏迷评分、美国国立卫生研究量卒中量表评分、血肿是否破入脑室及血浆脑钠肽水平均与转归结果有密切关系(X2 = 3.678, 7.096, t = 2.962, 2.361, 3.806, X2 = 4.687, t = 4.962, P < 0.05); Logistic回归分析发现血浆脑钠肽水平与急性脑出血患者的预后相关(P = 0.032, OR = 1.789, 95% CI 1.052~3.043)。结论:血浆BNP是脑出血患者转归的危险因素之一,对患者预后的判断有一定的价值。
Abstract: Objective: To study brain natriuretic peptide (BNP) levels and prognosis in patients with cerebral hemorrhage. Methods: Retrospective analysis of 109 cases with cerebral hemorrhage from December 2010 to December 2014 for the treatment was divided into 2 groups, according to the outcome of a good outcome group and poor outcome groups. The enzyme-linked immunosorbent assay (ELISA) was used for determination of plasma BNP. Result: There was a close relationship between patient outcomes and a previous history of stroke, smoking history, hematoma volume, Glasgow Coma Scale score, National Research Health Stroke Scale score, rupture of hematoma into the ventricle, plasma brain natriuretic peptide level. (X2 = 3.678, 7.096, t = 2.962, 2.361, 3.806, X2 = 4.687, t = 4.962, P < 0.05); Logistic regression analysis revealed a correlation between the prognosis of brain natriuretic peptide levels in patients with acute cerebral hemorrhage (P = 0.032, OR = 1.789, 95% CI 1.052 - 3.043). Conclusions: Plasma brain natriuretic peptide level is an independent risk factor for patients with cerebral hemorrhage and may be a useful prognostic factor for these patients.

文章引用: 韦道明, 朱雪红, 高丽丽, 杨瑞玲, 林菊珊, 廖远生, 李世举, 吴成翰. 血浆脑钠肽水平对急性脑出血患者转归的预测价值[J]. 国际神经精神科学杂志, 2015, 4(4): 28-33. http://dx.doi.org/10.12677/IJPN.2015.44005

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