ACM  >> Vol. 6 No. 1 (March 2016)

    2型糖尿病多器官自身免疫反应机制研究进展
    The Research of Type 2 Diabetes Multiorgan Autoimmune Reaction Mechanism

  • 全文下载: PDF(335KB) HTML   XML   PP.13-16   DOI: 10.12677/ACM.2016.61003  
  • 下载量: 1,502  浏览量: 3,842  

作者:  

张 琨:上海中医药大学,上海 ;
寿伟臻:上海中医药大学附属龙华医院,上海

关键词:
2型糖尿病自身免疫反应机制Type 2 Diabetes Autoimmunity Reaction Mechanism

摘要:

在糖尿病患者中,2型糖尿病的发病人数占糖尿病总数的90%以上。医学界较统一的观点认为免疫介导的胰岛功能损伤是1型糖尿病的发病机制,胰岛素受体功能缺陷以及受体后信号转导障碍是2型糖尿病的发病机制。但是免疫机制在2型糖尿病的发生以及发展过程中也起着很重要的作用,虽然目前关于这方面的研究还不是很多,但是免疫机制对2型糖尿病重要作用必将成为新的研究热点。

In patients with diabetes, the number of the onset of type 2 diabetes accounts for more than 90% of the total number of diabetes. The medical profession unified a view that immune-mediated islet function damage is the pathogenesis of type 1 diabetes. The function of insulin receptor defects and post receptor signal transduction disorder is the pathogenesis of type 2 diabetes mellitus. But the immune mechanism in the process of the occurrence and development of type 2 diabetes also plays an important role. Though there is not much research on this subject, the immune mechanism of type 2 diabetes important role will become a new research hotspot.

文章引用:
张琨, 寿伟臻. 2型糖尿病多器官自身免疫反应机制研究进展[J]. 临床医学进展, 2016, 6(1): 13-16. http://dx.doi.org/10.12677/ACM.2016.61003

参考文献

[1] Shaw, J.E., Sicree, R.A. and Zimmet, P.Z. (2010) Global Estimates of the Prevalence of Diabetes for 2010 and 2030. Diabetes Research and Clinical Practice, 87, 4-14.
http://dx.doi.org/10.1016/j.diabres.2009.10.007
[2] Pietropaolo, M., Barinas-Mitchell, E., Pietropaolo, S.L., et al. (2000) Evidence of Islet Cell Autoimmunity in Elderly Patients with Type 2 Diabetes. Diabetes, 49, 32-38.
http://dx.doi.org/10.2337/diabetes.49.1.32
[3] Guest, C.B., Park, M.J., Johnson, D.R., et al. (2008) The Implica-tion of Proinflammatory Cytokines in Type 2 Diabetes. Frontiers in Bioscience, 13, 5187-5194.
[4] Akash, M.S., Shen, Q., Rehman, K., et al. (2012) Interleukin-1 Receptor Antagonist: A New Therapy for Type 2 Diabetes Mellitus. Journal of Pharmaceutical Sciences, 101, 1647-1658.
http://dx.doi.org/10.1002/jps.23057
[5] Mayer, A., Fabien, N., Gutowski, M.C., et al. (2007) Contrasting Cellular and Humoral Autoimmunity Associated with Latent Autoimmune Diabetes in Adults. European Journal of Endocrinology, 157, 53-61.
http://dx.doi.org/10.1530/EJE-07-0060
[6] 蔡晓凌, 祝方, 周祥海, 等. 胰腺自身免疫抗体对2型糖尿病患者胰岛β细胞功能的影响[J]. .临床荟萃, 2006, 21(8): 543-546.
[7] 杨琳. LADA胰岛的B细胞功能[J]. 国外医学内分泌学分册, 2001, 21(3): 143-146.
[8] Goel, A., Brooks-Worrell, B. and Palmer, J. (2005) T Cell Proliferative and Cytokine Responses to Islet Proteins in Autoantibody Negative Type 2 Patients. Diabetes, 54, A310.
[9] 邱明才, 林珊, 高志红, 等. 有胫前黑斑的2型糖尿病患者皮肤黑斑和肾活检[J]. 天津医药, 2004, 32(5): 257-259.
[10] 杜勇, 杨念生, 李幼姬, 等. 2型糖尿病患者合并非糖尿病肾损害的临床病理分析[J]. 中华糖尿病杂志, 2004, 12(6): 409-412.
[11] 刘刚, 王梅, 刘玉春, 等. 2型糖尿病患者合并非糖尿病性肾损害的临床病例分析[J]. 中华肾脏病杂志, 2002, 17(4): 226-230.
[12] Ha, H. and Kim, K.H. (1999) Pathogencsis of Diabetic Nephropathy: The Role of Oxidative Stress and Protein Kinase C. Diabetes Research and Clinical Practice, 45, 147-151.
http://dx.doi.org/10.1016/S0168-8227(99)00044-3
[13] 张蕊, 施毕旻. 2型糖尿病及大血管病变患者CD4+CD28−T细胞、CD4+CD25+T细胞亚群的变化及意义[J]. CJCM 中医临床研究, 2013, 5(18): 110-112.
[14] 高桦, 邱明才. 应加强对部分2型糖尿病患者多器官免疫损伤的研究[J]. 中华医学杂志, 2005, 85(12): 793-795.