阿尔茨海默症中Aβ诱导细胞凋亡机制研究进展
Research Progress of Aβ-Induced Cell Apoptosis in Alzheimer’s Disease
DOI: 10.12677/PI.2016.52006, PDF, HTML, XML, 下载: 2,546  浏览: 8,661  科研立项经费支持
作者: 李婷婷, 何 玲：中国药科大学，江苏 南京
关键词: 阿尔茨海默症；Aβ；细胞凋亡；Alzheimer’s Disease； Aβ； Cell Apoptosis
摘要: 细胞的过度凋亡可能是导致AD患者发生神经退行性病变的原因，Aβ作为老年斑的主要成分，是引发AD的关键因素。目前，Aβ诱导细胞凋亡已成为AD机制研究的热点，本文主要对Aβ诱导细胞凋亡的通路进行了综述。
Abstract: The excessive apoptosis of cell may result in neurodegenerative disease, and as the basis of senile plaque, Aβ is a key factor which induced AD. Now people pay much attention to Aβ-induced cell apoptosis related to the mechanism of AD. This review provides the pathways of Aβ-induced cell apoptosis in major.
文章引用：李婷婷, 何玲. 阿尔茨海默症中Aβ诱导细胞凋亡机制研究进展[J]. 药物资讯, 2016, 5(2): 33-37. http://dx.doi.org/10.12677/PI.2016.52006

参考文献

[1] Thies, W. and Bleiler, L. (2013) Alzheimer’s Disease Facts and Figures. Alzheimer’s & Dementia: The Journal of the Alz-heimer’s Association, 9, 208-245.
http://dx.doi.org/10.1016/j.jalz.2013.02.003
[2] Lee, J.W. (2003) Global Health Improvement and WHO: Shaping the Future. Lancet, 362, 2083-2088.
http://dx.doi.org/10.1016/S0140-6736(03)15107-0
[3] Ferri, C.P., Prince, M., Brayne, C., et al. (2005) Global Preva-lence of Dementia: A Delphi Consensus Study. Lancet, 366, 2112-2117.
http://dx.doi.org/10.1016/S0140-6736(05)67889-0
[4] Hardy, J. and Selkoe, D.J. (2002) The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics. Science, 297, 353-356.
http://dx.doi.org/10.1126/science.1072994
[5] Luo, X.T., Wang, C.M., Liu, Y., et al. (2015) New Multifunctional Melatonin-Derived Benzylpyridinium Bromides with Potent Cholinergic, Antioxidant, and Neuroprotective Properties as Innovative Drugs for Alzheimer’s Disease. European Journal of Medicinal Chemistry, 103, 302-311.
http://dx.doi.org/10.1016/j.ejmech.2015.08.052
[6] Won, U.J., Nygaard, H.B., Heiss, J.K., et al. (2012) Alzheimer Amyloid-β Oligomer Bound to Postsynaptic Prion Protein Activates Fyn to Impair Neurons. Nature Neuroscience, 15, 1227-1235.
http://dx.doi.org/10.1038/nn.3178
[7] Wang, S.W., Yang, S.-G., Liu, W., et al. (2016) Alpha-Tocopherol Quinine Ameliorates Spatial Memory Deficits by Reducing Beta-Amyloid Oligomers, Neuroinflammation and Oxidative Stress in Transgenic Mice with Alzheimer’s Disease. Behavioural Brain Research, 296, 109-117.
http://dx.doi.org/10.1016/j.bbr.2015.09.003
[8] Lonskaya, I., Hebron, M.L., Selby, S.T., et al. (2015) Nilotinib and Bosutinib Modulate Pre-Plaque Alterations of Blood Immune Markers and Neuro-Inflammation in Alzheimer’s Disease Models. Neuroscience, 304, 316-327.
http://dx.doi.org/10.1016/j.neuroscience.2015.07.070
[9] Kalra, J. and Khan, A. (2015) Reducing Aβ Load and Tau Phosphorylation: Emerging Perspective for Treating Alzheimer’s Disease. European Journal of Pharmacology, 764, 571-581.
http://dx.doi.org/10.1016/j.ejphar.2015.07.043
[10] Lloret, A., Fuchsberger, T., Giraldo, E., et al. (2015) Molecular Mechanisms Linking Amyloid β Toxicity and Tau Hyperphosphorylation in Alzheimer’s Disease. Free Radical Biology & Medicine, 83, 186-191.
http://dx.doi.org/10.1016/j.freeradbiomed.2015.02.028
[11] Burgess, A., Nhan, T., Moffatt, C., Klibanov, A.L. and Hynynen, K. (2014) Analysis of Focused Ultrasound-Induced Blood-Brain Barrier Permeability in a Mouse Model of Alz-heimer’s Disease Using Two-Photon Microscopy. Journal of Controlled Release, 192, 243-248.
http://dx.doi.org/10.1016/j.jconrel.2014.07.051
[12] Fernandez-Echevarria, C., Díaz, M., Ferrer, I., Canerina-Amaro, A. and Marin, R. (2014) Aβ promotes VDAC1 Channel Dephosphorylation in Neuronal Lipid Rafts. Relevance to the Mecha-nisms of Neurotoxicity in Alzheimer’s Disease. Neuroscience, 278, 354-366.
http://dx.doi.org/10.1016/j.neuroscience.2014.07.079
[13] 杨绍杰, 孟金萍, 等. 细胞凋亡信号转导通路的研究进展[J]. 中国比较医学杂志, 2007, 17(5): 297-301.
[14] 鲍娟, 杨期东, 等. Aβ1-42注射后大鼠海马神经元凋亡及线粒体凋亡途径相关蛋白表达变化的研究现代生物医学进展, 2008, 8(2): 246-248, 266.
[15] Larsen, B.D., Rampalli, S., Burns, L.E., Brunette, S., Dilworth, F.J. and Megeney, L.A. (2010) Caspase 3/Caspase- Activated DNase Promote Cell Differentiation by Including DNA Strand Breaks. Proceedings of the National Academy of Sciences of the United States of America, 107, 4230-4235.
http://dx.doi.org/10.1073/pnas.0913089107
[16] Zhang, F., Wan, F., Li, Z. and Zhang, F. (2016) 4SC-202 Activates ASK1-Dependent Mitochondrial Apoptosis Pathway to Inhibit Hepatocellular Carcinoma Cells. Biochemical & Biophysical Research Communications, 471, 267-273.
http://dx.doi.org/10.1016/j.bbrc.2016.01.030
[17] 秦亚彬. 孕酮对Aβ所致神经元损伤的保护作用及其机制研究[D]: [博士学位论文]. 石家庄: 河北医科大学, 2015.
[18] 王海燕, 王来栓, 归绥琪. 细胞凋亡通路研究进展[J]. 国外医学: 生理、病理科学与临床分册, 2003, 23(5): 490-492.
[19] 陈敬荣. 染料木素通过JNK调控Fas和Bcl-2家族抑制Aβ诱导PC12细胞凋亡的机制研究[D]: [硕士学位论文]. 广州: 广东药学院, 2015.
[20] Morishima, Y., Gotoh, Y., et al. (2001) Beta-Amyloid Induces Neuronal Apoptosis via a Mechanism That Involves the c-Jun N-Terminal Kinase Pathway and the Induction of Fas Ligand. The Journal of Neuroscience, 21, 7551-7560.
[21] 胡司淦. Fas系统在冠心病和慢性心力衰竭中的变化及意义[J]. 蚌埠医学院学报, 2006, 31(4): 439-444.
[22] Nakamura, K., Bossy-Wetzel, E., et al. (2000) Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis. The Journal of Cell Biology, 150, 731-740.
http://dx.doi.org/10.1083/jcb.150.4.731
[23] Li, L.M., Liu, Q.H., Qiao, J.-T. and Zhang, C. (2009) Aβ31-35-Induced Neuronal Apoptosis Is Mediated by JNK-De- pendent Extrinsic Apoptosis Pathway. Neuroscience Bulletin, 25, 361-366.
http://dx.doi.org/10.1007/s12264-009-0629-5
[24] 陈青格, 徐平, 等. 反式白藜芦醇对Aβ25-35致痴呆大鼠海马caspase12的影响[J]. 遵义医学院学报, 2012, 35(5): 397-382.