ACM  >> Vol. 6 No. 2 (June 2016)

    浅谈对食管癌防治研究的理解和思考
    The Understanding and Considering of Prevention and Treatment on Esophageal Cancer

  • 全文下载: PDF(354KB) HTML   XML   PP.93-97   DOI: 10.12677/ACM.2016.62017  
  • 下载量: 932  浏览量: 2,542   科研立项经费支持

作者:  

张冬云:南阳医学高等专科学校,基础医学部,河南 南阳

关键词:
食管癌理解思考Esophageal Cancer Understanding Considering

摘要:

食管癌是世界上最常见的恶性肿瘤之一,预后差,5年生存率仅15%左右。作者所在研究团队通过对食管癌高发区随访发现食管癌患者术后生存存在明显差异。针对这一生存现状,本文作者试着从外因与内因相结合、人群研究与实验室研究相结合、基础研究与临床研究相结合、传统研究与现代分子生物学技术相结合、研究者和研究对象、社会、医院相结合和人文关怀与心理干预等几个方面来初步探讨作者对食管癌研究与防治的一些理解。

Esophageal cancer (EC) is one of the six most common malignancies worldwide. Its prognosis was the worst; the survival rate of 5-years was only ten percent or so. During the field research in high incidence area, our study group founded that the survival time of some ESCC patients after their surgical operations was significantly difference. To this conditions, the aims is to discuss the un-derstanding and considering of esophageal cancer from some following ways: the combination of external and internal, population study and laboratory study, basical study and clinical study, local treatment and comprehension treatment, traditional study and modern molecular biology technology, researchers and research objects, sociology, hospital, humanistic care and psychological intervention.

文章引用:
张冬云. 浅谈对食管癌防治研究的理解和思考[J]. 临床医学进展, 2016, 6(2): 93-97. http://dx.doi.org/10.12677/ACM.2016.62017

参考文献

[1] Pennathur, A., Gibson, M.K., Jobe, B.A., et al. (2013) Oesophageal Carcinoma. Lancet, 381, 400-412.
http://dx.doi.org/10.1016/S0140-6736(12)60643-6
[2] Enzinger, P.C. and Mayer, R.J. (2003) Esophageal Cancer. The New England Journal of Medicine, 349, 2241-2252.
http://dx.doi.org/10.1056/NEJMra035010
[3] Fan, Y.J., Song, X., Li, J.L., et al. (2008) Esophageal and Gastric Cardia Cancers on 4238 Chinese Patients Residing in Municipal and Rural Regions: A Histopathological Comparison during 24-Year Period. World Journal of Surgery, 32, 1980-1988.
http://dx.doi.org/10.1007/s00268-008-9674-x
[4] 王立东, 刘敏, 张冬云, 等. 食管癌超长期和短期生存患者临床病理变化对比分析[J]. 肿瘤防治研究, 2014, 41(3): 193-198.
[5] Hongo, M., Nagasaki, Y., et al. (2009) Epi-demiology of Esophageal Cancer: Orient to Occident. Effects of Chronology, Geography and Ethnicity. Journal of Gastroenterology and Hepatology, 24, 729-735.
http://dx.doi.org/10.1111/j.1440-1746.2009.05824.x
[6] Wang, L.D., Zhou, Q., Feng, C.W., et al. (2002) Inter-vention and Follow-Up on Human Esophageal Precancerous Lesions in Henan, Northern China, a High-Incidence Area for Esophageal Cancer. Japanese Journal of Cancer and Chemotherapy, 29, 159-172.
[7] 陈伟三, 杨合麟. 广东省南澳县1987~1992年食管癌流行病学特点[J]. 癌症, 1996, 15(4): 274-276.
[8] Zhang, W., Bailey-Wilson, J.E., Li, W., et al. (2000) Segregation Analysis of Esophageal Cancer in a Moderately High-Incidence Area of Northern China. American Journal of Human Genetics, 67, 110-119.
http://dx.doi.org/10.1086/302970
[9] Wang, L.D., Chang, Z.W., Zhao, X.K., et al. (2009) Family History Anal-ysis on 24,077 Esophageal Cancer Patients from the High- and Low-Incidence Areas for Esophageal Cancer in Northern China. Proceedings of the American Association for Cancer Research, 50, 294-298.
[10] Zhang, G.H., Su, M., Wang, D.M., et al. (2010) Genetic Heterogeneity of Oesophageal Cancer in High-Incidence Areas of Southern and Northern China. PLoS One, 5, e9668.
http://dx.doi.org/10.1371/journal.pone.0009668
[11] Wang, L.D., Zhou, F.Y., Li, X.M., et al. (2010) Genome-Wide Association Study of Esophageal Squamous Cell Carcinoma in Chinese Subjects Identifies Susceptibility Loci at PLCEl and C200rf54. Nature Genetics, 42, 759-763.
http://dx.doi.org/10.1038/ng.648
[12] 邹建湘, 王立东. 对胃肠道肿瘤科研设计思路的思考[J]. 医学与哲学, 1999, 20(3): 51-52.
[13] 王立东,周琦,邢莹, 等. 食管癌高发区人群食管癌前病变基因 EGFR,C-Jun 和 Ras蛋白表达的研究[J]. 河南医科大学学报, 1995, 30(2): 143-145.
[14] Wang, L.D., Zheng, S., Liu, B., et al. (2003) CYP1A1, GSTs and mEH Polymorphisms and Susceptibility to Esophageal Carcinoma: Study of Population from a High Incidence Area in North China. World Journal of Gastroenterology, 9, 1394-1397.
[15] 马振海, 邢光明, 田晓峰, 等. 进展期胃癌术后生存质量影响因素探讨[J]. 医学与哲学, 2008, 29(3): 13-15.
[16] 赵英哲, 杜玲玲, 王荣军. 试论自杀的内因和外因[J]. 医学与哲学, 2005, 26(11): 58-61.
[17] 陈莉萍, 陈明秀. 综合医院住院患者的自杀行为及其伦理思考[J]. 中国医学伦理学, 2009, 22(2): 46-47.