翼状胬肉切除联合自体角膜缘干细胞移植术治疗翼状胬肉的临床疗效观察
The Efficacy of Treating Pterygium by Pterygium Excision Combined with Autologous Limbal Stem Cell Transplantation
摘要:
目的:观察和分析翼状胬肉切除联合自体角膜缘干细胞移植术治疗翼状胬肉的临床效果。方法:对85例85眼原发性翼状胬肉患者进行翼状胬肉切除联合自体角膜缘干细胞移植术治疗,观察术后1年胬肉的复发情况。结果:85例85眼中仅有4例4眼术后1年复发,复发率4.71%。结论:翼状胬肉切除联合自体角膜缘干细胞移植术术后复发率低,具有临床推广价值。
Abstract: Objective: To investigate the clinical effects of autologous limbal stem cell transplantation for treatment of pterygium. Method: We analyzed the pterygium recurrences on 85 cases (85 eyes) of primary pterygium treated by pterygium excision combined with autologous limbal stem cell transplantation after one year of operation. Results: One year after operation, 4 cases (4 eyes) were relapsed. The recurrence rate was 4.71%. Conclusion: Excision of pterygium combined with autologous limbal stem cell transplantation has low recurrence rate.
参考文献
[1]
|
Chui, J., Di Girolamo, N., Wakefield, D., et al. (2008) The Pathogenesis of Pterygium: Current Concepts and Their Therapeutic Im-plications. The Ocular Surface, 6, 24-43. http://dx.doi.org/10.1016/S1542-0124(12)70103-9
|
[2]
|
Moran, D.J. and Hollows, F.C. (1984) Pterygium and ultraviolet Radiation: A Positive Correlation. British Journal of Ophthalmology, 68, 343-346. http://dx.doi.org/10.1136/bjo.68.5.343
|
[3]
|
Kennedy, M., Kim, K.H., Harten, B., et al. (1997) Ultraviolet Irradiation Induces the Production of Multiple Cytokines by Human Corneal Cells. Investigative Ophthalmology & Visual Science, 8, 2483-2491.
|
[4]
|
Powers, M.R., Qu, Z., O’Brien, B., et al. (1997) Immunolocalization of bFGF in Pterygia: Association with Mast Cells. Cornea, 16, 545-549. http://dx.doi.org/10.1097/00003226-199709000-00010
|
[5]
|
Nolan, T.M., Di Girolamo, N., Coroneo, M.T., et al. (2004) Proliferative Effects of Heparin-Binding Epidermal Growth Factor-Like Growth Factor on Pterygium Epithelial Cells and Fibroblasts. Investigative Ophthalmology & Visual Science, 45, 110-113. http://dx.doi.org/10.1167/iovs.03-0046
|
[6]
|
Nakamura, M. and Nishida, T. (1999) Differential Effects of Epidermal Growth Factor and Interleukin 6 on Corneal Epithelial Cells and Vascular Endothelial Cells. Cornea, 18, 452-458.
http://dx.doi.org/10.1097/00003226-199907000-00011
|
[7]
|
刘祖国, 谢玉环, 张梅, 等. 表皮生长因子受体家族在翼状胬肉上皮内的异常表达[J]. 中华眼科杂志, 2000, 36(5): 372-374.
|
[8]
|
刘新, 肖颖, 盛传家, 郭健, 等. 翼状胬肉的发生与角膜缘干细胞缺乏的病理研究[J]. 中国实用眼科杂志, 2003, 21(7): 499-501.
|
[9]
|
王伟娟, 赫天耕, 史秀茹. 自体角膜缘上皮移植、羊膜移植与常规术式治疗翼状胬肉复发率的比较[J]. 眼外伤职业眼病杂志(附眼科手术), 2007, 29(11): 881-884.
|
[10]
|
郭淑菊. 角膜缘干细胞移植在眼科的临床应用及发展[J]. 中国组织工程研究与临床康复, 2007, 11(15): 2944- 2947.
|
[11]
|
夏红和, 严宗辉. 翼状胬肉切除联合自体角膜缘干细胞移植治疗原发性翼状胬肉的Meta分析[J]. 眼科新进展, 2010, 30(4): 361-366.
|
[12]
|
陈莲英, 蔡召统, 王喜, 谢宝贤. 翼状胬肉切除联合自体角膜缘干细胞移植术70例疗效观察[J]. 齐齐哈尔医学院学报, 2013, 34(19): 2861-2862.
|
[13]
|
郑慧君, 余健儿, 李爽, 张春燕. 翼状胬肉不同手术方法疗效分析[J]. 中国实用眼科杂志, 2005, 23(8): 839-841.
|