血清唾液酸浓度与2型糖尿病患者全视网膜光凝术后黄斑水肿的关系

Relationship between Serum Sialic Acid Concentration and Macular Edema in Patients with Type 2 Diabetes Mellitus Treated with Panretinal Photocoagulation

摘要: 目的：探讨2型糖尿病患者血清唾液酸浓度与全视网膜激光光凝术后糖尿病性黄斑水肿的相关性。方法：选取102例2型糖尿病患者，糖尿病视网膜病变分级均为III~IV期，激光治疗前均无黄斑水肿病变。由同一医生分4次进行全视网膜激光光凝治疗，观察激光治疗后黄斑水肿情况。采取外周静脉血后用比色法测量血清唾液酸浓度，用视网膜血管荧光造影方法判断黄斑区水肿程度。结果：102例糖尿病患者平均血清唾液酸浓度为106.65 ± 10.21 mmol/l，激光治疗后发生糖尿病性黄斑水肿的患者为22例，其中1级水肿10例，2级水肿5例，3级水肿7例。未发生黄斑水肿的患者血清唾液酸浓度为96.33 ± 10.39 mmol/l，发生黄斑水肿的患者中血清唾液酸浓度为120.01 ± 17.71 mmol/l，两者差异具有统计学意义(P < 0.05)。血清唾液酸浓度与黄斑水肿严重程度有显著正相关(r = 0.68, P < 0.05)。结论：2型糖尿病患者血清唾液酸浓度与视网膜激光光凝术后黄斑水肿的发生密切相关。

Abstract: Objective: To explore the association between serum sialic acid concentration and macular edema in patients with type 2 Diabetes mellitus treated with panretinal photocoagulation (PRP). Method： A total of 102 type 2 Diabetes mellitus patients with III-IV diabetic retinopathy but without macular edema were enrolled. They were treated with 4 times of panretinal photocoagulation by the same physician and the occurrence of macular edema was recorded. Then used the peripheral venous blood to test the serum sialic acid by colorimetry and graded the macular edema based on fundus fluorescein angiography (FFA). Result: The mean serum sialic acid concentration of 102 diabetes patients was 106.65 ± 10.21 mmol/l. 22 patients had macular edema after the PRP treatment, including ten with Grade 1 macular edema, five with Grade 2 macular edema and seven with Grade 3 macular edema. The mean serum sialic acid concentration of the patients without and with macular edema was 96.33 ± 10.39 mmol/l and 120.01 ± 17.71 mmol/l, respectively. The difference was statistically (P < 0.05). There was a significant positive correlation between the serum sialic acid concentration and maclar edema grade (r = 0.68, P < 0.05). Conclusion: Serum sialic acid concentration was closely related to the occurrence of macular edema in type 2 Diabetes mellitus patients treated with PRP.