同型半胱氨酸与脑卒中相关性研究进展

Research Advances in the Correlation of Homocysteine and Stroke

摘要: 血中同型半胱氨酸浓度与心脑血管病发病密切相关，可能作为独立危险因素增加脑卒中发病率及复发风险。高浓度同型半胱氨酸可以通过使机体凝血功能异常、损伤血管内皮细胞及抑制H₂S生成等机制促使脑卒中的发生。一定剂量的维生素B6、B12、叶酸混合制剂治疗可以有效地降低脑卒中及严重血管疾病的复发率。本文从同型半胱氨酸在体内的代谢、血中浓度与脑卒中发生机制及治疗等方面对同型半胱氨酸与脑卒中的相关性做一阐述。

Abstract: The level of serum homocysteine is closely associated with the onset of cardio-cerebrovascular disease, and may be as an independent risk factor for increased risk of stroke incidence and re-currence. High levels of Hcy, called hyperhomocysteinaemia, can make the function of coagulant abnormal, damage vascular endothelial cell and inhibit H₂S generation mechanism to promote the occurrence of cerebral apoplexy. A dose of vitamin B6, B12, folic acid mixture preparation treat-ment can effectively reduce the recurrence of stroke and severe vascular disease. In this paper，we briefly introduced the correlation of homocysteine and stroke from the following aspects: the me-tabolism of homocysteine in the body, blood concentration and the mechanism and treatment of stroke, etc.