膀胱原发性腺癌临床病理特点及研究进展

Clinicopathologic Characteristics and Research Progress in Primary Adenocarcinoma of Bladder

摘要: 膀胱原发性腺癌是一种比较少见的恶性肿瘤，恶性程度较高，预后差。本文回顾性分析2例膀胱原发性腺癌患者的临床资料、病理资料及随访结果，患者均经手术治疗。2例膀胱腺癌均为老年男性，占同期350例膀胱癌的0.2%，肿瘤均为膀胱腔内单发病灶。临床主要症状为无痛性肉眼血尿，术前临床均未能获确切诊断。组织学主要以形态不一、大小不等的异型腺体组成，腺腔内含有黏液，细胞异型性大，癌组织在膀胱壁呈浸润性生长。免疫组化染色CK7(+)，CK20(−)。

Abstract: Primary adenocarcinoma of the bladder is a relatively rare cancer, and it has high degree of ma-lignancy and poor prognosis. The clinical and pathological data and follow-up results of two patients with primary adenocarcinoma of bladder underwent operation were analyzed. Two cases were elderly male patients, and primary adenocarcinoma accounted for 0.2% of all bladder carcinoma (350 cases) for the same period. Intravesical tumors were single lesion. The main clinical manifestation was gross hematuria. All patients on accurate diagnosis were not made preopera-tively. Microscopically, the tumor consisted of various shaped glands with different size, glandular cavity contained mucus, and the atypia of cell was big. Cancer cell in the bladder wall showed in-filtrative growth. Immunohistochemical study showed that the tumor cells were strongly positive for CK7, and negative for CK20.