PI  >> Vol. 6 No. 1 (February 2017)

    浅议AUC/MIC (AUIC)的定义和单位
    Discussion on the Definition and Unit of AUC/MIC (AUIC)

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作者:  

俞 岚:湖北第二师范学院,湖北 武汉;
周 洁:武汉大学人民医院,湖北 武汉;
高鸿慈:湖北中医药大学药学院,湖北 武汉

关键词:
药动学/药效学AUC/MICAUICPharmacokinetics/Pharmacodynamics AUC/MIC AUIC

摘要:

目的:讨论药动学/药效学(PK/PD)的参数AUC/MIC的定义、单位的混乱局面。方法:查阅国内外有关文献,作数理推导并与国内文献进行比对。结果与结论:AUC/MIC的定义和单位国内外文献有三种,到现在还没有定下来。在使用该参数时,必须给出是哪一种定义和单位,以便实验室、临床上进行操作。

Objective: To discuss the chaos about the definition and unit of parameter AUC/MIC of the phar-macokinetics/pharmacodynamics (PK/PD). Method: The related literature at home and abroad has been reviewed, and then we made mathematical derivation compared with the domestic literature. Results and Conclusion: There are three kinds of definition and unit of AUC/MIC in the literature at home and abroad, which have not been decided until now. When using the parameter, its definition and unit must be given, in order for the laboratory operation, and clinical use.

文章引用:
俞岚, 周洁, 高鸿慈. 浅议AUC/MIC (AUIC)的定义和单位[J]. 药物资讯, 2017, 6(1): 12-16. https://doi.org/10.12677/PI.2017.61003

参考文献

[1] 姜运英, 文爱东, 主编. 临床药物治疗学[M]. 第4版. 北京: 人民卫生出版社, 2016: 132-135.
[2] 李俊, 主编. 临床药理学[M]. 第5版. 北京: 人民卫生出版社, 2013: 339.
[3] 魏敏杰, 杜智敏, 主编. 临床药理学[M]. 第2版. 北京: 人民卫生出版社, 2014: 50.
[4] 刘克辛, 主编. 临床药物代谢动力学[M]. 第2版. 北京: 人民卫生出版社, 2014: 370.
[5] 张菁, 郁继诚, 施耀国, 等. 左氧氟沙星药代动力学/药效学研究[J]. 中华医学杂志, 2005, 85(27): 1926-1932.
[6] 陈迁, 梅和坤, 白楠, 等. 硝基咪唑类药物在人体内代谢的研究进展[J]. 中国药学杂志, 2015, 50(14): 1169-1173.
[7] 高鸿慈, 陈华庭, 主编. 实用药学计算[M]. 北京: 化学工业出版社, 2007: 199-201, 296-333.
[8] Mouton, J.W., Dudley, M.N., Cars, O., et al. (2002) Standardization of Pharmacokinetic/Pharmacodynamic (PK/PD) Terminology for Anti-Infective Drugs. International Journal of Antimicrobial Agents, 19, 355-358.
https://doi.org/10.1016/S0924-8579(02)00031-6
[9] Mouton, J.W., Dudley, M.N., Cars, O., et al. (2005) Standardization of Pharmacokinetic/Pharmacodynamic (PK/PD) Terminology for Anti-Infective Drugs: An Update. Journal of Antimicrobial Chemotherapy, 55, 601-607.
https://doi.org/10.1093/jac/dki079
[10] 赵香兰. 抗菌药PK/PD研究与临床合理用药方案[Z/OL]. http://www.doc88.com/p-336761961069.html
[11] 王睿. 抗菌药物PK/PD与临床应用研究[Z/OL]. http://www.docin.com/p-296039545.html
[12] Barriere, S.L., Ely, E., .Kapusnik, J.E., et al. (1985) Analysis of a New Method for Assessing Activity of combinations of Antimicrobials: Area under the Bactericidal Activity Curve. Journal of Antimicrobial Chemotherapy, 16, 49-59.
https://doi.org/10.1093/jac/16.1.49
[13] Toutain, P.L., Mélou, B. and Martinez, M. (2007) AUC/MIC: A PK/PD Index for Antibiotics with a Time Dimension or Simply a Dimensionless Scoring Factor? Journal of Antimicrobial Chemotherapy, 60, 1185-1188.
https://doi.org/10.1093/jac/dkm360
[14] Papich, M.G. (2014) Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling and the Rational Selection of Dosage Regimes for the Prudent Use of Antimicrobial Drugs. Veterinary Microbiology, 171, 480-486.
https://doi.org/10.1016/j.vetmic.2013.12.021