肢端肥大症患者生长激素水平及其与临床资料、生化指标及甲状腺激素水平的关系分析

Growth Hormone Level in Patients with Acromegaly and Its Relationship with Clinical Data, Biochemical Indexes and Thyroid Hormone Levels

摘要: 目的：探讨肢端肥大症患者生长激素水平及其与临床资料、生化指标及甲状腺激素水平之间的关系。方法：回顾性分析2012年1月~2016年12月在山西医科大学附属人民医院神经外科就诊65例肢端肥大症患者的一般临床资料、肝肾功能等生化指标及甲状腺功能。结果：肢端肥大症患者生长激素水平与临床资料、肝肾功能无相关性(r = −0.057~−0.104，P均 > 0.05)；与总胆固醇(TC)呈正相关(r = 0.279, P <0.05)，与LDL、HDL、TG无相关性(r = 0.104, 0.185, −0.104, P > 0.05)；与TSH呈负相关(r = −0.402, P < 0.01)；与TT₄水平呈正相关(r = 0.332, P < 0.01)；与FT₃、TT₃、FT₄之间无相关性(r = 0.151, −0.06, 0.243, P > 0.05)。结论：肢端肥大症型垂体腺瘤的血清生长激素水平与肿瘤体积、肝功、肾功无相关性。血脂方面，其与TC水平正相关，与LDL、HDL、TG无相关性。甲状腺激素方面，其与TSH水平呈负相关，与TT₄水平呈正相关，与FT₃、TT₃、FT₄之间无相关性。

Abstract: Objective: To explore the growth hormone (GH) level in the patients with acromegaly and its re-lationship with clinical data, biochemical indexes and thyroid hormone levels. Methods: The clinical data, biochemical indicators such as liver and kidney function and thyroid function of 65 acromegaly patients with pituitary adenomas, who visited Shanxi Medical University Affiliated People’s Hospital from January 2012 to December 2016, were analyzed retrospectively. Results: There was no significant correlation among serum GH, clinical data, liver and kidney function in the patients with acromegaly (r = −0.057 - −0.104, P > 0.05). Serum GH has positive correlation with TC (r = 0.279, P < 0.05) and no correlation with LDL, HDL, TG (r = 0.104, 0.185, −0.104, P > 0.05). Serum GH has negative correlation with TSH (r = −0.402, P < 0.01); but positive correlation with TT₄ (r = 0.332, P < 0.01) and no correlation with FT₃, TT₃, FT₄ (r = 0.151, −0.06, 0.243, P > 0.05). Conclusions: The serum GH level in the patients with acromegaly is insignificantly related to the adenomas volume, liver function and renal function. In the aspect of blood lipid, , the serum GH level was positively correlated with TC level, and had no correlation with LDL, HDL, TG. In the aspect of thyroid function, the serum GH level was negatively correlated with TSH level and positively correlated with TT₄ level, and no correlation with FT₃, TT₃, FT₄.