Keratograph眼表综合分析仪评估纹眼线患者眼表状况

Evaluation of Ocular Surface Condition in the Tattoo on Eyelid Margin by Noninvasive Keratograph

摘要: 目的：观察不同年龄段纹眼线患者眼表状况。方法：随机选取眼科门诊纹眼线女性就诊患者60例(120只眼)，年龄24~65岁。行眼表疾病指数(ocular surface disease index, OSDI)问卷调查，裂隙灯检查，格瓦拉–眼表综合分析仪Keratograph 5M检查，根据OSDI干眼分级标准将患者分为干眼组(28例56眼)和正常组(32例64眼)，分别对两组的眼表和睑板腺状况进行评估与比较。结果：OSDI值：干眼组(27.02 ± 14.35)分，正常组OSDI值(7.29 ± 3.36)分；干眼组明显高于正常组(P < 0.001)；NIBUT：干眼组5.93 ± 3.07正常组：13.23 ± 4.89；泪河高度：干眼组(0.18 ± 0.04) mm，正常组(0.23 ± 0.03) mm，这两项指标在干眼组均明显低于正常组(P < 0.001)；角膜荧光素染色评分：干眼组(3.51 ± 1.67)分，正常组(1.23 ± 2.32)分；睑板腺缺失评分：干眼组(3.35 ± 1.25)分，正常组(0.65 ± 0.59)分，这两项指标在干眼组明显高于正常组(P < 0.001)；纳入的60例纹眼线患者的角膜荧光素染色评分与睑板腺的缺失评分呈正相关(rs = 0.838, P = 0.000)。结论：纹眼线患者干眼发病率为46.67%，睑板腺功能障碍是纹眼线患者发生干眼的重要病因之一，Keratograph 5M非侵入式眼表综合分析仪可无创性客观评价患者眼表状况。

Abstract: Objective: To observe the ocular surface condition of patients with tattoo on eyelid margin in the dif-ferent age group. Methods: 60 female patients (120 eyes) of tattoo on eyelid margin, from 24 - 65 years old, were randomly involved in this study. The ocular surface disease index (OSDI) questionnaire, slit lamp examination and Keratograph 5M were administered. Patients were then divided into two groups according to OSDI score: Dry eye group (28 patients, 56 eyes) and normal group (32 patients, 64 eyes), then the ocular surface and meibomian gland condition were compared and evaluated. Results: OSDI grade: dry eye group (27.02 ± 14.35), normal group (7.29 ± 3.36), the dry eye group were higher than the normal group (P < 0.001). Noninvasive break-up time (NIBUT) in the dry eye group and normal group were (5.93 ± 3.07)s and (13.23 ± 4.89)s; the tear meniscus height in the dry eye group and normal group were (0.18 ± 0.04) mm and (0.23 ± 0.03) mm. The two indexes were significantly smaller in the dry eye group than the normal group (all P < 0.001). Corneal fluoresce scores in the dry eye group and normal group were (3.51 ± 1.67), (1.23 ± 2.32); meibomian gland dropout scores were (3.35 ± 1.25), (0.65 ± 0.59) respectively. The two indexes were significantly higher in the dry eye group than the normal group (all P < 0.001). Positive correlation was found between meibomian gland dropout scores and corneal fluoresce scores in the two groups (rs = 0.838, P = 0.000). Conclusion: The rate of pathogenesis in the patients with tattoo on eyelid margin was 46.67%; meibomian gland dysfunction is one of the important factors in patients with the tattoo on eyelid margin. The Keratograph 5M appears to provide an effective noninvasive method for assessing the tattoo on eyelid margin’ ocular surface situation.