IJM  >> Vol. 6 No. 1 (March 2017)

    Overview—Cell Migration Models

  • 全文下载: PDF(5988KB) HTML   XML   PP.24-36   DOI: 10.12677/IJM.2017.61004  
  • 下载量: 2,569  浏览量: 3,729   国家自然科学基金支持


冯继菊,汤立群,刘泽佳:华南理工大学土木与交通学院工程力学系,广东 广州

细胞迁移模型外界源伪足Cell Migration Model External Source Pseudopod



Cell migration occurred along with the whole life process of biology, both the embryonic devel-opment and disease are inseparable from the cell migration. In addition, cell migration model also can assist the experimental verification. Therefore, the cell migration and the related model play an important role in the analysis of various cell behaviors. In this paper, we introduce a comprehensive review of research on cell migration, which includes the forms of cell migration, cell model and various models of cell migration. There are some summary and discussion on the advantages and disadvantages of models in the domestic and foreign research on cell migration.

冯继菊, 汤立群, 刘泽佳. 细胞迁移模型综述[J]. 力学研究, 2017, 6(1): 24-36. https://doi.org/10.12677/IJM.2017.61004


[1] Bao, G. and Suresh, S. (2003) Cell and Molecular Mechanics of Biological Materials. Nature Materials, 2, 715-725.
[2] Janmey, P.A. and Mcculloch, C.A. (2007) Cell Mechanics: Integrating Cell Responses to Mechanical Stimuli. Annual Review of Biomedical Engineering, 9, 1-34.
[3] Borau, C., Kamm, R.D. and Garcia-Aznar, J.M. (2011) Mechano-Sensing and Cell Migration: A 3D Model Approach. Physical Biology, 8, 1-13.
[4] Karcher, H., Lammerding, J., Huang, H.D., et al. (2003) A Three-Dimensional Viscoelastic Model for Cell Deformation with Experimental Verification. Biophysical. Journal, 85, 3336-3349.
[5] Fletcher, D.A. and Mullins, D. (2010) Cell Mechanics and the Cytoskeleton. Nature, 463, 485-492.
[6] Cukierman, E., Pankov, R., Stevens, D.R., et al. (2001) Taking Cell-Matrix Adhesions to the Third Dimension. Science, 294, 1708-1712.
[7] Giannone, G., Dubin-Thaler, B.J., Rossier, O., et al. (2007) Lamellipodial Actin Mechanically Links Myosin Activity with Adhesion-Site Formation. Cell, 128, 561-575.
[8] Qian, J., Wang, J. and Gao, H. (2008) Lifetime and Strength of Adhesive Molecular Bond Clusters between Elastic Media. Langmuir, 24, 1262-1270.
[9] Belletti, B., Nicoloso, M.S., Schiappacassi, M., et al. (2008) Stathmin Activity Influences Sarcoma Cell Shape, Motility, and Metastatic Potential. Molecular Biology of the Cell, 19, 2003-2013.
[10] Friedl, P., Zanker, K.S. and Brocker, E.B. (1998) Cell Migration Strategies in 3D Extracellular Matrix: Differences in Morphology, Cell Matrix Interactions, and Integrin Function. Microscopy Research and Technique, 43, 369-378.
[11] Even-Ram, S. and Yamada, K.M. (2005) Cell Migration in 3D Matrix. Current Opinion in Cell Biology, 17, 524-532.
[12] Friedl, P. and Gilmour, D. (2009) Collective Cell Migration in Morphogenesis, Regeneration and Cancer. Nature Reviews Molecular Cell Biology, 10, 445-457.
[13] Wolf, K. and Friedl, P. (2009) Mapping Proteolytic Cancer Cell-Extracellular Matrix Interfaces. Clinical & Experimental Metastasis, 26, 289-298.
[14] Tsujioka, M. (2011) Cell Migration in Multicellular Environments. Development, Growth & Differentiation, 53, 528- 537.
[15] Blaser, H., Reichman-Fried, M., Castanon, I., et al. (2006) Migration of Zebra Fish Primordial Germ Cells: A Role for Myosin Contraction and Cytoplasmic Flow. Developmental Cell, 11, 613-627.
[16] Ridley, A.J. (2011) Life at the Leading Edge. Cell, 145, 1012-1022.
[17] Charras, G. and Paluch, E. (2008) Blebs Lead the Way: How to Migrate without Lamellipodia. Nature Reviews Molecular Cell Biology, 9, 730-736.
[18] Wolf, K., Mazo, I., Leung, H., et al. (2003) Compensation Mechanism in Tumor Cell Migration: Mesenchymal-Amoeboid Transition after Blocking of Pericellular Proteolysis. The Journal of Cell Biology, 160, 267-277.
[19] Friedl, P. and Wolf, K. (2003) Tumour-Cell Invasion and Migration: Diversity and Escape Mechanisms. Nature Reviews Cancer, 3, 362-374.
[20] Sanz-Moreno, V. and Marshall, C.J. (2010) The Plasticity of Cytoskeletal Dy-namics Underlying Neoplastic Cell Migration. Current Opinion in Cell Biology, 22, 690-696.
[21] Friedl, P. and Wolf, K. (2010) Plasticity of Cell Migration: A Multiscale Tuning Model. The Journal of Cell Biology, 188, 11-19.
[22] Bergert, M., Chandradoss, S.D., Desai, R.A., et al. (2012) Cell Mechanics Control Rapid Transitions between Blebs and Lamellipodia during Migration. Proceedings of the National Academy of Sciences of the United States of America, 109, 14434-14439.
[23] Lim, F.Y., Koon, Y.L. and Chiam, K.H. (2013) A Computational Model of Amoeboid Cell Migration. Computer Methods in Biomechanics and Biomedical Engineering, 16, 1085-1095.
[24] Lammermann, T. and Sixt, M. (2009) Mechanical Modes of “Amoeboid” Cell Migration. Current Opinion in Cell Biology, 21, 636-644.
[25] Barnhart, E.L., Lee, K.C., Keren, K., et al. (2011) An Adhe-sion-Dependent Switch between Mechanisms That Determine Motile Cell Shape. PLOS Biology, 9, 19.
[26] Paulus, W., Baur, I., Beutler, A.S., et al. (1996) Diffuse Brain Invasion of Glioma Cells Requires Beta 1 Integrins. Laboratory Investigation: A Journal of Technical Methods and Pathology, 75, 819-826.
[27] Shao, D.Y., Levine, H. and Rappel, W.J. (2012) Coupling Actin Flow, Adhesion, and Morphology in a Computational Cell Motility Model. Proceedings of the National Academy of Sciences of the United States of America, 109, 6851- 6856.
[28] Paluch, E., Sykes, C., Prost, J., et al. (2006) Dynamic Modes of the Cortical Actomyosin Gel during Cell Locomotion and Division. Trends in Cell Biology, 16, 5-10.
[29] Charras, G.T., Hu, C.-K., Coughlin, M., et al. (2006) Reassembly of Contractile Actin Cortex in Cell Blebs. The Journal of Cell Biology, 175, 477-490.
[30] Charras, G.T., Coughlin, M., Mitchison, T.J., et al. (2008) Life and Times of a Cellular Bleb. Biophysical Journal, 94, 1836-1853.
[31] Charras, G.T. (2008) A Short History of Blebbing. Journal of Microscopy-Oxford, 231, 466-478.
[32] Charras, G.T., Yarrow, J.C., Horton, M.A., et al. (2005) Non-Equilibration of Hydrostatic Pressure in Blebbing Cells. Nature, 435, 365-369.
[33] Paluch, E., Piel, M., Prost, J., et al. (2005) Cortical Actomyosin Breakage Triggers Shape Oscillations in Cells and Cell Fragments. Biophysical Journal, 89, 724-733.
[34] Rintoul, R.C. and Sethi, T. (2001) The Role of Extracellular Matrix in Small-Cell Lung Cancer. The Lancet. Oncology, 2, 437-442.
[35] Friedl, P., Borgmann, S. and Brocker, E.B. (2001) Amoeboid Leukocyte Crawling through Extracellular Matrix: Lessons from the Dictyostelium Paradigm of Cell Movement. Journal of Leukocyte Biology, 70, 491-509.
[36] Friedl, P. and Wolf, K. (2003) Proteolytic and Non-Proteolytic Migration of Tumour Cells and Leucocytes. Biochemical Society Symposium, 277-285.
[37] Yoshida, K. and Soldati, T. (2006) Dissection of Amoeboid Movement into Two Mechanically Distinct Modes. Journal of Cell Science, 119, 3833-3844.
[38] 樊学军. 细胞力学[J]. 力学进展, 1995, 25(2): 197-208.
[39] 李敬生, 昌庆, 等. 细胞结构的力学模型及模拟的最新进展[J]. 力学进展, 2004, 34(3): 393-398.
[40] Lim, C.T., Zhou, E.H. and Quek, S.T. (2006) Mechanical Models for Living Cells—A Review. Journal of Biomechanics, 39, 195-216.
[41] Evans, E. and Yeung, A. (1989) Apparent Viscosity and Cortical Tension of Blood Granulocytes Determined by Micropipet Aspiration. Biophysical Journal, 56, 151-160.
[42] 李宝龙. 细胞骨架力学模型的研究进展[J]. 四川建筑科学, 2004, 40(2): 34-38.
[43] Lauffenburger, D.A. and Horwitz, A.F. (1996) Cell Migration: A Physically Integrated Molecular Process. Cell, 84, 359-369.
[44] Ridley, A.J., Schwartz, M.A., Burridge, K., et al. (2003) Cell Migration: Integrating Signals from Front to Back. Science, 302, 1704-1709.
[45] Friedl, P. and Wolf, K. (2009) Proteolytic Interstitial Cell Migration: A Five-Step Process. Cancer and Metastasis Reviews, 28, 129-135.
[46] Gibson, L.J. and Ashby, M.F. (1982) The Mechanics of Three-Dimensional Cellular Materials. Proceedings of the Royal Society of London. Series A, Mathematical and Physical Sciences, 382, 43-59.
[47] Ingber, D.E. (1993) Cellular Tensegrity: Defining New Rules of Biological Design That Govern the Cytoskeleton. Journal of Cell Science, 104, 613-627.
[48] Ingber, D.E. (1998) Cellular Basis of Mechanotransduction. The Biological Bulletin, 194, 323-325.
[49] Yeung, A. and Evans, E. (1989) Cortical Shell-Liquid Core Model for Passive Flow of Liquid-Like Spherical Cells into Micropipets. Biophysical Journal, 56, 139-149.
[50] Theret, D.P., Levesque, M.J., Sato, M., et al. (1988) The Application of a Homogeneous Half-Space Model in the Analysis of Endothelial Cell Micropipette Measurements. Journal of Biomechanical Engineering, 110, 190-199.
[51] Schmid-Schonbein, G.W., Sung, K.L., Tozeren, H., et al. (1981) Passive Mechanical Properties of Human Leukocytes. Biophysical Journal, 36, 243-256.
[52] Satcher, R.L., Jr. and Dewey, C.F., Jr. (1996) Theoretical Estimates of Mechanical Properties of the Endothelial Cell Cytoskeleton. Biophysical Journal, 71, 109-118.
[53] Stamenovic, D. and Coughlin, M.F. (1999) The Role of Prestress and Architecture of the Cytoskeleton and Deformability of Cytoskeletal Filaments in Mechanics of Adherent Cells: A Quantitative Analysis. Journal of Theoretical Biology, 201, 63-74.
[54] Stamenovic, D. and Coughlin, M.F. (2000) A Quantitative Model of Cellular Elasticity Based on Tensegrity. Journal of Biomechanical Engineering, 122, 39-43.
[55] Coughlin, M.F. and Stamenovic, D. (2003) A Prestressed Cable Network Model of the Adherent Cell Cytoskeleton. Biophysical Journal, 84, 1328-1336.
[56] Ross, C. and Ethier, C.A.S. (2007) Introductory Biomechanics: From Cells to Organisms.
[57] Wang, N., Butler, J.P. and Ingber, D.E. (1993) Mechanotransduction across the Cell Surface and through the Cytoskeleton. Science, 260, 1124-1127.
[58] Wang, N. and Ingber, D.E. (1994) Control of Cytoskeletal Mechanics by Extracellular Matrix, Cell Shape, and Mechanical Tension. Biophysical Journal, 66, 2181-2189.
[59] Hubmayr, R.D., Shore, S.A., Fredberg, J.J., et al. (1996) Pharmacological Activation Changes Stiffness of Cultured Human Airway Smooth Muscle Cells. The American Journal of Physiology, 271, C1660-C1668.
[60] Cai, S., Pestic-Dragovich, L., O’donnell, M.E., et al. (1998) Regulation of Cytoskeletal Mechanics and Cell Growth by Myosin Light Chain Phosphorylation. American Journal of Physiology-Cell Physiology, 275, C1349-C1356.
[61] Mcconnaughey, W.B. and Petersen, N.O. (1980) Cell Poker: An Apparatus for Stress-Strain Measurements on Living Cells. The Review of Scientific Instruments, 51, 575-580.
[62] Petersen, N.O., Mcconnaughey, W.B. and Elson, E.L. (1982) Dependence of Locally Measured Cellular Deformability on Position on the Cell, Temperature, and Cytochalasin B. Proceedings of the National Academy of Sciences of the United States of America, 79, 5327-5331.
[63] Zahalak, G.I., Mcconnaughey, W.B. and Elson, E.L. (1990) Determination of Cellular Mechanical Properties by Cell Poking, with an Application to Leukocytes. Journal of Biomechanical Engineering, 112, 283-294.
[64] Bausch, A.R., Ziemann, F., Boulbitch, A.A., et al. (1998) Local Measurements of Viscoelastic Parameters of Adherent Cell Surfaces by Magnetic Bead Microrheometry. Biophysical Journal, 75, 2038-2049.
[65] Bausch, A.R., Hellerer, U., Essler, M., et al. (2001) Rapid Stiffening of Integrin Receptor-Actin Linkages in Endothelial Cells Stimulated with Thrombin: A Magnetic Bead Microrheology Study. Biophysical Journal, 80, 2649-2657.
[66] Dong, C., Skalak, R. and Sung, K.L. (1991) Cytoplasmic Rheology of Passive Neutrophils. Biorheology, 28, 557-567.
[67] Hochmuth, R.M., Ting-Beall, H.P., Beaty, B.B., et al. (1993) Viscosity of Passive Human Neutrophils Undergoing Small Deformations. Biophysical Journal, 64, 1596-1601.
[68] Tsai, M.A., Frank, R.S. and Waugh, R.E. (1993) Passive Me-chanical Behavior of Human Neutrophils: Power-Law Fluid. Biophysical Journal, 65, 2078-2088.
[69] Dong, C., Skalak, R., Sung, K.L., et al. (1988) Passive Deformation Analysis of Human Leukocytes. Journal of Biomechanical Engineering, 110, 27-36.
[70] Mow, V.C., Kuei, S.C., Lai, W.M., et al. (1980) Biphasic Creep and Stress Relaxation of Articular Cartilage in Compression? Theory and Experiments. Journal of Biomechanical Engineering, 102, 73-84.
[71] Leterrier, J.F. (2001) Water and the Cytoskeleton. Cellular and Molecular Biology, 47, 901-923.
[72] Shin, D. and Athanasiou, K. (1999) Cytoindentation for Obtaining Cell Biomechanical Properties. Journal of Orthopaedic Research, 17, 880-890.
[73] Mahaffy, R.E., Shih, C.K., Mackintosh, F.C., et al. (2000) Scanning Probe-Based Frequency-Dependent Microrheology of Polymer Gels and Biological Cells. Physical Review Letters, 85, 880-883.
[74] Maksym, G.N., Fabry, B., Butler, J.P., et al. (2000) Mechanical Properties of Cultured Human Airway Smooth Muscle Cells from 0.05 to 0.4 Hz. Journal of Applied Physiology, 89, 1619-1632.
[75] Fabry, B., Maksym, G.N., Butler, J.P., et al. (2001) Scaling the Microrheology of Living Cells. Physical Review Letters, 87, 4.
[76] Alcaraz, J., Buscemi, L., Grabulosa, M., et al. (2003) Microrheology of Human Lung Epithelial Cells Measured by Atomic Force Microscopy. Biophysical Journal, 84, 2071-2079.
[77] Mijailovich, S.M., Kojic, M., Zivkovic, M., et al. (2002) A Finite Element Model of Cell Deformation during Magnetic Bead Twisting. Journal of Applied Physiology, 93, 1429-1436.
[78] 余昶, 张怡, 刘肖珩. 流体剪切应力诱导内皮细胞迁移的力学-化学信号途径[J]. 航天医学工程, 2007, 20(4): 308-312.
[79] 彭亦良, 梁后杰. 癌细胞运动与迁移的分子机制[J]. 中国生物化学与分子生物学报, 2006, 22(10): 794-798.
[80] Zigmond, S.H., Levitsky, H.I. and Kreel, B.J. (1981) Cell Polarity: An Examination of Its Behavioral Expression and Its Consequences for Polymorphonuclear Leukocyte Chemotaxis. The Journal of Cell Biology, 89, 585-592.
[81] Weiner, O.D. (2002) Regulation of Cell Polarity during Eukaryotic Chemotaxis: The Chemotactic Compass. Current Opinion in Cell Biology, 14, 196-202.
[82] Hoeller, O. and Kay, R.R. (2007) Chemotaxis in the Absence of PIP3 Gradients. Current Biology, 17, 813-817.
[83] Van Haastert, P.J.M. and Bosgraaf, L. (2009) The Local Cell Curvature Guides Pseudopodia towards Chemoattractants. Hfsp Journal, 3, 282-286.
[84] King, J.S. and Insall, R.H. (2009) Chemotaxis: Finding the Way forward with Dictyostelium. Trends in Cell Biology, 19, 523-530.
[85] Bahat, A., Caplan, S.R. and Eisenbach, M. (2012) Thermotaxis of Human Sperm Cells in Extraordinarily Shallow Temperature Gradients over a Wide Range. PLoS ONE, 7, e41915.
[86] Zhao, M. (2009) Electrical Fields in Wound Healing—An Overriding Signal That Directs Cell Migration. Seminars in Cell & Developmental Biology, 20, 674-682.
[87] Zaman, M.H., Kamm, R.D., Matsudaira, P., et al. (2005) Computational Model for Cell Migration in Three-Dimen- sional Matrices. Biophysical Journal, 89, 1389-1397.
[88] Dokukina, I.V. and Gracheva, M.E. (2010) A Model of Fibroblast Motility on Substrates with Different Rigidities. Biophysical Journal, 98, 2794-2803.
[89] Lo, C.M., Wang, H.B., Dembo, M., et al. (2000) Cell Movement Is Guided by the Rigidity of the Substrate. Biophysical Journal, 79, 144-152.
[90] Discher, D.E., Janmey, P. and Wang, Y.L. (2005) Tissue Cells Feel and Respond to the Stiffness of Their Substrate. Science, 310, 1139-1143.
[91] Wong, H.C. and Tang, W.C. (2011) Computational Study of Local and Global ECM Degradation and the Effects on Cell Speed and Cell-Matrix Tractions. Nano Communication Networks, 2, 119-124.
[92] Jamaleddin Mousavi, S., Hamdy Doweidar, M. and Doblare, M. (2013) 3D Computational Modelling of Cell Migration: A Mechano-Chemo-Thermo-Electrotaxis Approach. Journal of Theoretical Biology, 329, 64-73.
[93] Mousavi, S.J., Doweidar, M.H. and Doblare, M. (2014) Computational Modelling and Analysis of Mechanical Conditions on Cell Locomotion and Cell-Cell Interaction. Computer Methods in Biomechanics and Biomedical Engineering, 17, 678-693.
[94] Bosgraaf, L. and Van Haastert, P.J.M. (2009) Navigation of Chemotactic Cells by Parallel Signaling to Pseudopod Persistence and Orientation. PLoS ONE, 4, e6842.
[95] Higazi, A.A., Kniss, D., Manuppello, J., et al. (1996) Thermotaxis of Human Trophoblastic Cells. Placenta, 17, 683- 687.
[96] Nishimura, K.Y., Isseroff, R.R. and Nuccitelli, R. (1996) Human Keratinocytes Migrate to the Negative Pole in Direct Current Electric Fields Comparable to Those Measured in Mammalian Wounds. Journal of Cell Science, 109, 199-207.
[97] Gou, X., Yang, H., Fahmy, T.M., et al. (2014) Direct Measurement of Cell Protrusion Force Utilizing a Robot-Aided Cell Manipulation System with Optical Tweezers for Cell Migration Control. The International Journal of Robotics Research, 33, 1782-1792.
[98] Yang, H., Gou, X., Wang, Y., et al. (2015) A Dynamic Model of Chemoattractant-Induced Cell Migration. Biophysical Journal, 108, 1645-1651.
[99] Van Haastert, P.J.M. (2010) Chemotaxis: Insights from the Extending Pseudopod. Journal of Cell Science, 123, 3031- 3037.
[100] Allena, R. (2013) Cell Migration with Multiple Pseudopodia: Temporal and Spatial Sensing Models. Bulletin of Mathematical Biology, 75, 288-316.
[101] Allena, R. and Aubry, D. (2012) “Run-and-Tumble” or “Look-and-Run”? A Mechanical Model to Explore the Behavior of a Migrating Amoeboid Cell. Journal of Theoretical Biology, 306, 15-31.