脑源性神经营养因子在阿尔茨海默症中作用研究进展

Research Progress of Brain-Derived Neurotrophic Factor in Alzheimer’s Disease

摘要: 阿尔茨海默症(AD)是引起老年痴呆的主要原因，其病理特征包括淀粉样斑块和神经纤维缠结。AD广泛的神经元和突触丢失引起记忆和认知功能进行性减退。脑源性神经营养因子(BDNF)是成人大脑内分布最广泛的神经营养因子。BDNF在记忆获得和巩固的细胞生物学基础突触发生及突触可塑性中发挥关键作用。研究表明，BDNF可能成为AD的生物标记和治疗靶标。本文主要对BDNF在AD中发挥的作用及其治疗策略进行综述。

Abstract: Alzheimer’s disease (AD) is one of the most common causes of dementia in the elderly. It is char-acterized by the accumulation of Aβ plaques and neurofibrillary tangles, which are accompanied by widespread neuronal and synaptic loss, causing progressive loss of memory and cognitive function. Brain-derived neurotrophic factor (BDNF) is the most widely distributed NTs in adult brain and is a key molecule in the maintenance of synaptic plasticity and synaptogenesis, which is the cellular biological basis of memory acquisition and consolidation. BDNF may play a potential role in the pathogenesis of Alzheimer’s disease. The review provides the role and therapeutic strategy of brain-derived neurotrophic factor in Alzheimer’s disease in major.

文章引用：冯晓文, 何玲. 脑源性神经营养因子在阿尔茨海默症中作用研究进展[J]. 药物资讯, 2017, 6(2): 31-35. https://doi.org/10.12677/PI.2017.62006

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