阴阳观点的老化修复论
Reconstruction of Ageing by Yin-Yang Doctrine
DOI: 10.12677/TCM.2017.62012, PDF, HTML, XML, 下载: 1,672  浏览: 4,914  科研立项经费支持
作者: 李宗谚:长庚大学传统中医研究所,台湾 桃园;张恒鸿:中国医药大学中医学院,台湾 台中;陈维熊:阳明大学医学院,台湾 台北
关键词: 阴阳学说老化Yin-Yang Doctrine Ageing Entropy
摘要: 阴阳循行在微观场域的推演与运作是一个非常成功的模式。人类的身体从受精卵这样隐含巨大能量的量子小宇宙原初体,诡异的发展成均衡运作的实质生命个体,此一过程不能缺少源源不断的能量条件,最终所呈现的确实是我们所熟悉的生命现象的种种特征,但是这个生意无限生物体依然未能免俗的也会受到热力熵乱流干扰。这项生命场域的转换被迫在无限发展中容许因为熵增加所带来的代谢不稳定与基因不稳定性,成为人类在疾病或老化讯息的密切关联。换句话说,熵是个干扰讯号,此一讯号让人类的DNA发展出适应节律的基因编码,这样一个方式让人类得以演化出更具适应能力的下一代。在此同时,我们付出一点点小小的代价,在生理学上我们称之为老化。黄帝内经运用古代阴阳抽象的思辨原则架构人体生命、健康和疾病防治的医学实践。因此,阴阳的中医学思维在各种生命活动的变化中建立起规律的应用基础。使病势的发展透过阴阳协调,达到防病祛邪的摄生原则。逆转老化的关键密码其实就是深藏在内经「去故就新,乃得真人。」
Abstract: Yin and yang recurrence that illustrates deduction and operation in the microscopic field is a very successful model for life. It is an amazing story to show how the organic operation of the “individual” human being from a fertilized eggs. This process can’t be a lack of energy supplementation, and the final phenomenon really presents the various life characteristics we are familiar with. But this infinite living organism is still interfering with entropy turbulence. The transformation of the living life is forced to allow metabolic instability and genetic instability in the evolution under expanding entropy signaling, which is closely linked to the disease or ageing. Entropy is a subject worthy of concern in our life. In other words, the entropy is an interference factor; this noise spectrum makes the human DNA to develop a code to adapt to the rhythm of body language; this effect allows human beings to evolve more adaptable next generation; at the same time, we pay a little functional loss; in physiology, we make it as ageing in life. The Yellow Emperor’s Classic of Medicine manipulates the medical practice of human life, health and disease prevention by using the ancient principle of balance, of Yin Yang doctrine, as represented by the transformation of the energies of the universe. Therefore, the pivotal role of Yin Yang theory of thinking process in a variety of life activities is changeable and compliance is to establish the basis of health philosophy, so that the organs can be restored to normalcy and good circulation and diseases prevention also through the coordination of Yin and Yang imbalance, to achieve the purpose of prevention of diseases and eliminate pathogens in our body. The passwords to reverse the ageing actually encode the message in the Yellow Emperor’s Classic of Medicine text: “Exclude old entropy, and meanwhile accept new energy. Everyone lived more than one hundred years without showing the usual signs of ageing”. Precise words make longevity come true.
文章引用:李宗谚, 张恒鸿, 陈维熊. 阴阳观点的老化修复论[J]. 中医学, 2017, 6(2): 68-75. https://doi.org/10.12677/TCM.2017.62012

参考文献

[1] Greider, C.W. and Blackburn, E.H. (1989) A Telomeric Sequence in the RNA of Tetrahymena Telomerase Required for Telomere Repeat Synthesis. Nature, 337, 331-337.
https://doi.org/10.1038/337331a0
[2] Harman, D. (1965) Aging: A Theory Based on Free Radical and Radiation Chemistry. Journal of Gerontology, 11, 298-300.
https://doi.org/10.1093/geronj/11.3.298
[3] Hayflick, L. (1965) The Limited in Vitro Lifetime of Human Diploid Cell Strains. Experimental Cell Research, 37, 614-636.
[4] Calder, N. (2003) Magic Universe: The Oxford Guide to Modern Science. Oxford University Press, Oxford, 424.
[5] Jaskelioff, M., Muller, F.L., Paik, J.H., et al. (2011) Telomerase Reactivation Reverses Tissue Degeneration in Aged Telomerase-Deficient Mice. Nature, 469, 102-106.
https://doi.org/10.1038/nature09603
[6] Shay, J.W. and Wright, W.E. (2000) Hayflick, His Limit, and Cellular Ageing. Nature Reviews Molecular Cell Biology, 1, 72-76.
[7] Hayflick, L. (2004) Aging: The Reality “Anti-Aging” Is an Oxymoron. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 59, B573-B578.
https://doi.org/10.1093/gerona/59.6.b573
[8] Hayflick, L. (2007) Biological Aging Is No Longer an Unsolved Problem. Annals of the New York Academy of Sciences, 100, 1-13.
https://doi.org/10.1196/annals.1395.001
[9] Hayflick, L. (2007) Entropy Explains Aging, Genetic Determinism Explains Longevity, and Undefined Terminology Explains Misunderstanding Both. PLOS Genetics, 3, e220.
https://doi.org/10.1371/journal.pgen.0030220
[10] Lee, T.Y., Chang, H.H. and Chen, W.S. (2017) Recursion of Life Cycle. Traditional Chinese Medicine.
[11] Hill, A.V., Long, C.N. and Lupton, H. (1924) Muscular Exercise, Lactic Acid, and the Supply and Utilisation of Oxygen. Proceedings of the Royal Society B: Biological Sciences, 96, 438.
https://doi.org/10.1098/rspb.1924.0037
[12] Kresge, N., Simoni, R.D. and Hill, R.L. (2005) Otto Fritz Meyerhof and the Elucidation of the Glycolytic Pathway. The Journal of Biological Chemistry, 280, e3.
[13] Warburg, O.H. (1956) On the Origin of Cancer Cells. Science, 123, 309-314.
https://doi.org/10.1126/science.123.3191.309
[14] Lu, J., Tan, M. and Cai, Q. (2015) The Warburg Effect in Tumor Progression: Mitochondrial Oxidative Metabolism as an Anti-Metastasis Mechanism. Cancer Letters, 356, 156-164.
[15] Boland, M.L., Chourasia, A.H. and Macleod, K.F. (2013) Mitochondrial Dysfunction in Cancer. Frontiers in Oncology, 3, 292.
https://doi.org/10.3389/fonc.2013.00292
[16] Martinez-Outschoorn, U., Sotgia, F. and Lisanti, M.P. (2014) Tumor Microenvironment and Metabolic Synergy in Breast Cancers: Critical Importance of Mitochondrial Fuels and Function. Seminars in Oncology, 41, 195-216.
https://doi.org/10.1053/j.seminoncol.2014.03.002
[17] Garland, J. (2013) Energy Management—A Critical Role in Cancer Induction? Critical Reviews in Oncology/Hematology, 88, 198-217.
[18] Ritchie, W., Granjeaud, S., Puthier, D. and Gautheret, D. (2008) Entropy Measures Quantify Global Splicing Disorders in Cancer. PLOS Computational Biology, 4, e10.
https://doi.org/10.1371/journal.pcbi.1000011
[19] Medawar, P.B. (1952) An Unsolved Problem of Biology. HK Lewis and Co.
[20] Charlesworth, B. (2000) Fisher, Medawar, Hamilton and the Evolution of Aging. Genetics, 156, 927-931.
[21] Mitchell, P. (1961) Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic Type of Mechanism. Nature, 191, 144-148.
https://doi.org/10.1038/191144a0
[22] Mailloux, R.J. and Harper, M.E. (2011) Uncoupling Proteins and the Control of Mitochondrial Reactive Oxygen Species Production. Free Radical Biology & Medicine, 51, 1106-1115.
[23] Jastroch, M., Divakaruni, A.S., Mookerjee, S., et al. (2010) Mitochondrialproton and Electron Leaks. Essays in Biochemistry, 47, 53-67.
https://doi.org/10.1042/bse0470053
[24] Dröse, S. and Brandt, U. (2012) Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain. Advances in Experimental Medicine and Biology, 748, 145-169.
https://doi.org/10.1007/978-1-4614-3573-0_6
[25] Yin, F., Sancheti, H. and Cadenas, E. (2012) Mitochondrial Thiols in the Regulation of Cell Death Pathways. Antioxidants & Redox Signaling, 17, 1714-1727.
https://doi.org/10.1089/ars.2012.4639
[26] Stoner, C.D. (2000) Inquiries into the Nature of Free Energy and Entropy in Respect to Biochemical Thermodynamics. Entropy, 2, 106-141.
https://doi.org/10.3390/e2030106
[27] Guggenheim, E.A. (1959) Thermodynamics, an Advanced Treatment for Chemists and Physicists. North-Holland Publishing Company, Amster-dam.
[28] Kittel, C. and Kroemer, H. (1980) Thermal Physics. W.H. Freeman and Company, New York.
[29] Davies, P., Demetrius, L., Jack, A. and Tuszynski, J.A. (2011) Cancer as a Dynamical Phase Transition. Theoretical Biology and Medical Modelling, 8, 30-46.
https://doi.org/10.1186/1742-4682-8-30
[30] Charames, G.S. and Bapat, B. (2003) Genomic Instability and Cancer. Current Molecular Medicine, 3, 589-596.
[31] Wang, C.H., Wu, S.B., Wu, Y.T. and Wei, Y.H. (2013) Oxidative Stress Response Elicited by Mitochondrial Dysfunction: Implication in the Pathophysiology of Aging. Experimental Biology and Medicine, 238, 450-460.
https://doi.org/10.1177/1535370213493069
[32] Hekimi, S., Lapointe, J. and Wen, Y. (2011) Taking a “Good” Look at Free Radicals in the Aging Process. Trends in Cell Biology, 21, 569-576.
[33] Lee, T.Y., Chang, H.H. and Chen, W.S. (2017) Quantum Properties of Yin-Yang Recurrence of Chinese Medicine. Traditional Chinese Medicine.