TCM  >> Vol. 6 No. 2 (May 2017)

    益气养阴方联合I125粒子植入治疗晚期肺癌的近期疗效研究
    Short-Term Effects Research of Qi-Replenishing and Yin-Nourishing Prescription Combined with Iodine-125 Seeds Implantation in Treating Advanced Lung Cancer

  • 全文下载: PDF(524KB) HTML   XML   PP.76-81   DOI: 10.12677/TCM.2017.62013  
  • 下载量: 126  浏览量: 180  

作者:  

包 祺,寿伟臻,俞杞泉,吴春晓:上海市中医药大学附属龙华医院胸外科,上海

关键词:
晚期肺癌I125粒子益气养阴方Advanced Lung Cancer Iodine-125 Seeds Qi-Replenishing and Yin-Nourishing Prescription

摘要:

观察益气养阴方联合I125放射性粒子植入治疗晚期肺癌的近期疗效及不良反应发生情况。方法:对60例晚期肺癌患者,随机分为治疗组与对照组,每组30例。对照组予CT引导下经皮行I125粒子植入术,治疗组予I125粒子植入术后,联合服用益气养阴方。观察术后不良反应发生情况,术后4月评估实体瘤疗效。结果:① 治疗组实体瘤有效率83.33%,对照组为70.83%;组间实体瘤疗效差异有统计学意义(P < 0.05)。② 术后治疗组发热、痰中带血、刺激性咳嗽、白细胞下降的发生率分别为16.67%、10.00%、13.33%、0,对照组上述不良反应的发生率分别为76.67%、36.67%、53.33%、26.67%,差异均有统计学意义(P < 0.05)。结论:益气养阴方联合I125粒子植入治疗晚期肺癌的近期疗效显著,不良反应发生率低。

Objective: To observe short-term effects and side effects of Qi-replenishing and Yin-nourishing Prescription combined iodine-125 seeds implantation in treating advanced lung cancer. Methods: 60 advanced lung cancer patients were randomized into treatment group and control group, 30 cases in each group. Control group was percutaneously implanted with iodine-125 seeds by CT guiding, and treatment group was combined with Qi-replenishing and Yin-nourishing Prescription, observing the side effects after treatment and evaluating the curative effect of solid tumor 6 months later. Results: ① The solid tumor effective rate was 83.33% in the treatment group and 70.83% in the control group. There was a significant difference between two groups (P < 0. 05). ② The rate of side effects, such as fever, bloody sputum, irritating cough and neutropenia, was 16.67%, 10.00%, 13.33% and 0 in the treatment group. The relative rate was 76.67%, 36.67%, 53.33% and 26.67% in the control group. The difference was significant too (P < 0. 05). Conclusion: The short-term effects of Qi-replenishing and Yin-nourishing Prescription combined with iodine-125 seeds implantation in treating advanced lung cancer are better with lower side-effect rate.

文章引用:
包祺, 寿伟臻, 俞杞泉, 吴春晓. 益气养阴方联合I125粒子植入治疗晚期肺癌的近期疗效研究[J]. 中医学, 2017, 6(2): 76-81. https://doi.org/10.12677/TCM.2017.62013

参考文献

[1] 王俊杰. 放射性粒子治疗肿瘤临床应用规范[M]. 北京: 北京人学医学出版社, 2011: 29.
[2] 郑筱萸. 中药新药临床研究指导原则[M]. 北京: 中国医药科技出版社, 2002: 156-163.
[3] 鲍云华, 李俭杰. 介绍新的实体瘤治疗反应评价标准(RECIST) [J]. 中国肺癌杂志, 2005, 2(8): 77-78.
[4] 李春杰, 孙建立, 刘苓霜, 等. 益气养阴方对C57小鼠Lewis肺癌ERα及CyclinD1表达的影响[J]. 中华中医药杂志, 2010, 25(4): 578-581.
[5] 徐蔚杰, 孙慧莉, 李和根, 等. 益气养阴方联合化疗治疗中晚期非小细胞肺癌30例[J]. 肿瘤学杂志, 2009, 15(8): 725-727.
[6] 李炯, 沈德义, 陆巍, 等. 益气养阴方对围手术期肺癌患者IL-2 sIL-2R的影响[J]. 辽宁中医杂志, 2007, 34(7): 907-908.