TCM  >> Vol. 6 No. 2 (May 2017)

    针刺干预海洛因成瘾脑损伤作用的研究进展
    The Research Progress of Acupuncture Effect on Heroin Addiction Brain Damage

  • 全文下载: PDF(701KB) HTML   XML   PP.86-90   DOI: 10.12677/TCM.2017.62015  
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作者:  

蔡兴慧,高永龙,张利达:安徽中医药大学针灸骨伤临床学院,安徽 合肥;
吴生兵:安徽中医药大学实验科研中心,安徽 合肥;
张荣军,侯晓蓉:安徽中医药大学中西医结合临床学院,安徽 合肥;
宋小鸽:安徽中医药大学针灸经络研究所,安徽 合肥

关键词:
针刺海洛因成瘾脑损伤干预作用综述Acupuncture Heroin Addiction Brain Damage Intervention Effect Review

摘要:

针灸戒毒康复的研究一直是我国在防治药物依赖领域中的一大特色,本文对海洛因成瘾致脑损伤的实验观察研究,以及针灸干预海洛因成瘾脑损伤的研究概况,作如下综述。目的是分析探讨针刺干预海洛因复吸大鼠脑神经细胞凋亡的作用,为针灸戒毒康复的临床应用提供实验依据,促进针灸疗法的临床应用。

Study of acupuncture and rehabilitation is the one big characteristic in the field of prevention and treatment of drug dependence. In the paper, the review on experimental observation and acupuncture intervention of heroin addiction is in order to study the acupuncture intervention neuron apoptosis of heroin readdiction rat, to provide experimental basis for acupuncture drug rehabilitation, and to promote acupuncture in drug rehabilitation.

文章引用:
蔡兴慧, 高永龙, 张利达, 吴生兵, 张荣军, 侯晓蓉, 宋小鸽. 针刺干预海洛因成瘾脑损伤作用的研究进展[J]. 中医学, 2017, 6(2): 86-90. https://doi.org/10.12677/TCM.2017.62015

参考文献

[1] Gardini, S. and Venneri, A. (2012) Reduced Grey Matter in the Posterior Insula as a Structural Vulnerability or Diathesis to Addiction. Brain Research Bulletin, 87, 205-211.
[2] Kumar, N., Bhalla, M.C., Frey, J.A., et al. (2015) Intraparenchymal Hemorrhage after Heroin Use. American Journal of Emergency Medicine, 33, 1109.e3-4.
[3] 尹恝, 潘速跃, 周亮, 吕田明, 罗一峰. 陆兵勋海洛因海绵状白质脑病病理分析[J]. 南方医科大学学报, 2007, 27(6): 881-883.
[4] Haselhort, R., Dursteler-Mac Farland, K.M., Scheffler, K., Ladewig, D., Muller-spahn, F., Stohler, R., Seeling, J. and Seifritz, E. (2002) Frontocortical N-Acetylaspartate Reduction Associated with Long-Term IV Heroin Use. Neurology, 58, 305.
https://doi.org/10.1212/WNL.58.2.305
[5] 黄帆. 毒品戒断后出现广泛中枢神经系统损害[J]. 中国神经精神疾病杂志, 2001, 27(1): 42-43.
[6] Chuang, C.H., Hsu, Y.C., Wang, C.C., et al. (2013) Cerebral Blood Flow and Apoptosis-Associated Factor with Electroacupuncture in a Traumatic Brain Injury Rat Model. Acupuncture in Medicine, 31, 395-403.
https://doi.org/10.1136/acupmed-2013-010406
[7] Tang, W.C., Hsu, Y.C., Wang, C.C., et al. (2016) Early Electroacupuncture Treatment Ameliorates Neuroinflammation in Rats with Traumatic Brain Injury. BMC Complementary and Alternative Medicine, 16, 470.
https://doi.org/10.1186/s12906-016-1457-6
[8] Shi, Y., Quan, R., Li, C., et al. (2016) The Study of Traditional Chinese Medical Elongated-Needle Therapy Promoting Neurological Recovery Mechanism after Spinal Cord Injury in Rats. Journal of Ethnopharmacology, 187, 28-41.
[9] Renfu, Q., Rongliang, C., Mengxuan, D., et al. (2014) Anti-Apoptotic Signal Transduction Mechanism of Electroacupuncture in Acute Spinal Cord Injury. Acupuncture in Medicine, 32, 463-471.
https://doi.org/10.1136/acupmed-2014-010526
[10] Hou, X., Zhang, R., Lv, H., et al. (2014) Acupuncture at Baihui and Dazhui Reduces Brain Cell Apoptosis in Heroin Readdicts. Neural Regeneration Research, 9, 164-170.
https://doi.org/10.4103/1673-5374.125345
[11] Zhang, Y., Lan, R., Wang, J., et al. (2015) Acupuncture Reduced Apoptosis and Up-Regulated BDNF and GDNF Expression in Hippocampus Following Hypoxia-Ischemia in Neonatal Rats. Journal of Ethnopharmacology, 172, 124- 132.
[12] Guo, H.D., Zhu, J., Tian, J.X., et al. (2016) Electroacupuncture Improves Memory and Protects Neurons by Regulation of the Autophagy Pathway in a Rat Model of Alzheimer’s Disease. Acupuncture in Medicine, 34, 449-456.
https://doi.org/10.1136/acupmed-2015-010894
[13] Lin, R., Chen, J., Li, X., et al. (2016) Electroacupuncture at the Baihui Acupoint Alleviates Cognitive Impairment and Exerts Neuroprotective Effects by Modulating the Expression and Processing of Brain-Derived Neurotrophic Factor in APP/PS1 Transgenic Mice. Molecular Medicine Reports, 13, 1611-1617.
[14] Liu, F., Jiang, Y.J., Zhao, H.J., et al. (2015) Electroacupuncture Ameliorates Cognitive Impairment and Regulates the Expression of Apopto-sis-Related Genes Bcl-2 and Bax in Rats with Cerebral Ischaemia-Reperfusion Injury. Acupuncture in Medicine, 33, 478-484.
https://doi.org/10.1136/acupmed-2014-010728
[15] 王念, 张荣军, 侯晓蓉, 等. 针刺对海洛因复吸大鼠脑神经细胞凋亡的影响[J]. 安徽中医药大学学报, 2013, 32(5): 44-48.
[16] Upadhyay, J., Maleki, N., Potter, J., et al. (2010) Alterations in Brain Structure and Functional Connectivity in Prescription Opioid-Dependent Patients. Brain, 133, 2098-2114.
https://doi.org/10.1093/brain/awq138
[17] 罗良鸣, 刘建锋, 龚群, 等. 海洛因依赖对大鼠杏仁核突触数量及结构的影响[J]. 中国法医学杂志, 2016, 31(2): 134-136.
[18] 韦献良, 叶峻, 周燕. 海洛因成瘾大白鼠脑内神经元凋亡的超微结构观察[J]. 广西医科大学学报, 2004, 21(1): 31-33.
[19] 李一欣, 梁文妹. 海洛因依赖大鼠中脑腹侧被盖区β-EP的表达[J]. 贵阳医学院学报, 2013, 38(5): 458-460.
[20] 皮明山, 吴钰祥, 茹琴, 等. 常见毒品对大脑神经元损伤的研究进展[J]. 神经损伤与功能重建, 2014, 9(1): 63-67.
[21] 杨玲, 张更生, 赵鑫. 海洛因依赖者抑制控制功能的损伤机制及其可逆性[J]. 心理科学进展, 2014, 22(3): 439- 447.
[22] Pu, H., Wang, X., Zhang, J., et al. (2015) Cerebellar Neuronal Apoptosis in Heroin-Addicted Rats and ITS Molecular Mechanism. International Journal of Clinical and Experimental Pathology, 8, 8260-8267.
[23] Tan, M., Li, Z., Ma, S., et al. (2013) Heroin Activates Bim via c-Jun N-Terminal Kinase/c-Jun Pathway to Mediate Neuronal Apoptosis. Neuroscience, 233, 1-8.
[24] 蔡兴慧, 宋小鸽, 张荣军, 等. 针刺对海洛因复吸大鼠脑神经元超微结构变化的影响[J]. 中国药物依赖性杂志, 2012, 21(1): 26-29.
[25] Wei, Z., Wang, Y., Zhao, W., et al. (2017) Electro-Acupuncture Modulates L1 Adhesion Molecule Expression after Mouse Spinal Cord Injury. The American Journal of Chinese Medicine, 45, 37-52.
https://doi.org/10.1142/S0192415X17500045
[26] Lu, K.W., Yang, J., Hsieh, C.L., et al. (2016) Electroacupuncture Restores Spatial Learning and Downregulates Phosphorylated N-methyl-D-aspartate Receptors in a Mouse Model of Parkinson’s Disease. Acupuncture in Medicine, 2015, Article ID: 011041.
[27] Zhang, M., Xv, G.H., Wang, W.X., et al. (2017) Electroacupuncture Improves Cognitive Deficits and Activates PPAR- γ in a Rat Model of Alzheimer’s Disease. Acupuncture in Medicine, 35, 44-51.
https://doi.org/10.1136/acupmed-2015-010972
[28] Shi, G.X., Wang, X.R., Yan, C.Q., et al. (2015) Acupuncture Elicits Neuroprotective Effect by Inhibiting NAPDH Oxidase-Mediated Reactive Oxygen Species Production in Cerebral Ischaemia. Scientific Reports, 5, 17981.
[29] Wan, F., Niu, X., Song, Y.L., et al. (2016) The Role of Chinese Herbs and Acupuncture on the Inflammation Reaction after Cerebral Ischemia. Current Pharmaceutical Design, 22, 709-719.
https://doi.org/10.2174/1381612822666151204001348
[30] Chen, B., Tao, J., Lin, Y., et al. (2015) Electro-Acupuncture Exerts Beneficial Effects against Cerebral Ischemia and Promotes the Proliferation of Neural Progenitor Cells in the Cortical Peri-Infarct Area through the Wnt/β-Catenin Signaling Pathway. International Journal of Molecular Medicine, 36, 1215-1222.
https://doi.org/10.3892/ijmm.2015.2334
[31] Hou, X., Zhang, R., lv, H., et al. (2014) Acupuncture at Bai Hui and Da Zhui Reduces Brain Cell Apoptosis in Heroin Readdicts. Neteural Regeneration Research, 2, 164-170.
[32] 周雪琼, 贺凌飞, 余日安. 内质网应激及未折叠蛋白反应通路研究进展[J]. 中国职业医学, 2012, 39(3): 264-267.
[33] 王硕, 孟庆华, 秦秀德. 内质网应激与细胞凋亡[J]. 热带医学杂志, 2012, 12(5): 632-635.