TCM  >> Vol. 6 No. 2 (May 2017)

    原人参二醇及Compound K抑制肝细胞肝癌的作用及机制
    The Inhibitory Effect of Protopanoxadiol and Compound K on Hepatocellular Carcinoma and the Underlying Mechanisms

  • 全文下载: PDF(502KB) HTML   XML   PP.104-109   DOI: 10.12677/TCM.2017.62018  
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作者:  

张春蕾,宋海燕,季光:上海中医药大学附属龙华医院脾胃病研究所;
许阳贤:上海中医药大学附属龙华医院普外科

关键词:
肝细胞肝癌原人参二醇Compound KHepatocellular Carcinoma Protopanoxadiol Compound K

摘要:

中晚期肝癌及术后复发转移性肝癌目前仍然缺乏有效治疗手段。原人参二醇(protopanoxadiol, PPD)及人参皂苷Compound K是二醇型人参皂苷在体内的代谢产物。近年来多项研究发现这两种天然产物可通过诱导细胞凋亡、抑制细胞增殖、抑制血管生成、抑制转移等机制对多种肿瘤发挥抑瘤效应。其中对肝细胞肝癌的作用研究较多,抑癌效果尤为突出。本文就近年来PPD及Compound K抗肝细胞肝癌的作用和相关机制研究进行系统综述,以期有助于开发出有效治疗肝癌的天然药物。

There is still no effective treatment available for advanced liver cancer or the recurrence and me-tastasis after surgical resection. Protopanoxadiol (PPD) and ginsenoside Compound K are the me-tabolites of protopanaxadiol-type ginsenosides in vivo. In recent years, a number of studies have found that these two kinds of natural products could play a role of tumor suppression through in-ducing cell apoptosis, inhibiting cell proliferation, inhibiting angiogenesis and limiting tumor cell metastasis. Among them, there are many studies focusing on the effect of PPD or Compound K on hepatocellular carcinoma (HCC), in which the anti-cancer effect is prominent. This paper reviews the recent studies on the role of PPD/Compound K in HCC and the related mechanisms, in order to ben-efit the development of new effective natural medicine to treat HCC.

文章引用:
张春蕾, 宋海燕, 许阳贤, 季光. 原人参二醇及Compound K抑制肝细胞肝癌的作用及机制[J]. 中医学, 2017, 6(2): 104-109. https://doi.org/10.12677/TCM.2017.62018

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