MS  >> Vol. 7 No. 3 (May 2017)

    Immobilization of Different Chiral Tartaric Acid on Ti-O Surface and Blood Compatibility Evaluation

  • 全文下载: PDF(574KB) HTML   XML   PP.345-352   DOI: 10.12677/MS.2017.73047  
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韩鸿红,范永鸿,王 科,潘夏鑫,翁亚军:西南交通大学材料先进技术教育部重点实验室,材料科学与工程学院,四川 成都

手性酒石酸纤维蛋白原变性血小板粘附与激活Chirality Tartaric Acid Fibrinogen Denaturation Platelet Adhesion and Activation



Chirality is one of the basic characteristics of life system, which has a high degree of chiral selectivity, surface chirality may significantly affect the biological function of biomaterials. In this paper, different chiral tartaric acid molecules were immobilized on the surface of Ti-O films. XPS test results showed the peak of nitrogen appeared on the samples which had deposited dopamine, the ratio of nitrogen to carbon was increased when hexamethylendiamine was introduced. When chiral tartaric acid was grafted, the ratio of oxygen to carbon was increased. XPS results showed that all surfaces had been successfully prepared. The water contact angle test results showed that no difference was present on the L-surface and D-surface, indicating that surface chirality had little effect on surface hydrophobicity. The effects of chirality on the blood compatibility of materials were evaluated by fibrinogen denaturation test and platelet adhesion and activation assay in vitro. Compared with L-tartaric acid surface, D-tartaric acid surface showed a lower degree of denatura-tion of fibrinogen, less platelet adhesion and a lower degree of platelet activation. These results indicate that chirality cannot be ignored in the anticoagulant properties of biomaterials, which provides a new idea for the development of anticoagulant materials with excellent properties.

韩鸿红, 范永鸿, 王科, 潘夏鑫, 翁亚军. Ti-O膜表面固定不同手性酒石酸及其血液相容性评价[J]. 材料科学, 2017, 7(3): 345-352.


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