银杏内生真菌次级代谢产物及抗肿瘤活性研究进展
Advances of Secondary Metabolites and Their Antitumor Activities of Endophytic Fungi from Ginkgo biloba
DOI: 10.12677/OJNS.2017.52029, PDF, HTML, XML, 下载: 1,721  浏览: 4,025 
作者: 吴海月, 卢洪保, 王 韬, 原玉洁, 刘 帅, 何 庆：德州学院，生命科学学院，山东 德州
关键词: 银杏；内生真菌；次级代谢物；抗肿瘤活性；Ginkgo biloba； Endophytic Fungi； Secondary Metabolites； Antitumor Activities
摘要: 银杏是我国特产药用植物，具有抗肿瘤作用的白果黄素、聚戊烯醇都是从银杏中提取出来的。然而银杏生长缓慢，不利于其药效作用的开发，因此银杏内生真菌成为了研究热点，人们期待其能成为银杏药物的新来源。目前有关银杏内生真菌的研究并不多，对银杏内生真菌抗肿瘤活性的研究更是稀少，本文对银杏内生真菌次级代谢产物及其抗肿瘤活性的研究进展进行了综述。
Abstract: Ginkgo biloba is a Chinese medicinal plant; ginkgo flavonoids and polypentyl alcohol with anti- tumor effect are extracted from it. This tree grows very slow, so endophytic fungi from Ginkgo biloba is attracting research interest, which is expected to be a new source of compounds for developing anti-cancer drugs. At present, there are few studies on endophytic fungi of Ginkgo biloba, and the research for the anti-tumor activity of endophytic fungi of Ginkgo biloba is rare. This paper describes the advances of secondary metabolites and their antitumor activities of endophytic fungi from Ginkgo biloba.
文章引用：吴海月, 卢洪保, 王韬, 原玉洁, 刘帅, 何庆. 银杏内生真菌次级代谢产物及抗肿瘤活性研究进展[J]. 自然科学, 2017, 5(2): 218-222. https://doi.org/10.12677/OJNS.2017.52029

参考文献

[1] Challis, G.L. (2008) Mining Microbial Genomes for New Natural Products and Biosynthetic Pathways. Microbiology, 154, 1555-1569.
https://doi.org/10.1099/mic.0.2008/018523-0
[2] Koehn, F.E. and Carter, G.T. (2005) The Evolving Role of Natural Products in Drug Discovery. Nature Reviews Drug Discovery, 4, 206-220.
https://doi.org/10.1038/nrd1657
[3] 傅晓艺, 刘桂茹, 杨学举. 银杏的药用价值及组织培养研究[J]. 中国农学通报, 2005, 21(8): 314-317.
[4] Harvey, A.L. (2008) Natural Products in Drug Discovery. Drug Discovery Today, 13, 894-901.
[5] 邱德有. 一种云南红豆杉内生真菌的分离[J]. 真菌学报, 1994, 13(4): 314-316.
[6] 郭波, 李海燕, 张玲琪. 一种产长春新碱内生真菌的分离[J]. 云南大学学报(自然科学版), 1998, 20(3): 214-215.
[7] 李海燕, 曾松荣, 张玲琪. 云南桃儿七植株地下茎内生真菌多样性及有价值菌株的筛选[J]. 西南农业学报, 1999, 12(4): 123-125.
[8] Wang, Y., Lv, J., Cheng, Y., et al. (2015) Apoptosis Induced by Ginkgo biloba (EGb761) in Melanoma Cells Is Mcl-1-Dependent. PLoS ONE, 10, e0124812.
https://doi.org/10.1371/journal.pone.0124812
[9] Qin, J.C., Zhang, Y.M., Gao, J.M., et al. (2009) Bioactive Metabolites Produced by Chaetomium globosum, an Endophytic Fungus Isolated from Ginkgo biloba. Bioorganic & Medicinal Chemistry Letters, 19, 1572-1574.
[10] Li, H.Q., Li, X.J., Wang, Y.L., et al. (2011) Antifungal Metabolites from Chaetomium globosum, an Endophytic Fungus in Ginkgo biloba. Biochemical Systematics and Ecology, 39, 876-879.
[11] 郭建新, 孙广宇, 张荣, 等. 银杏内生真菌抗真菌活性菌株的分离和筛选[J]. 西北农业学报, 2005, 14(4): 14-17.
[12] 高樱萍, 葛飞, 张慧敏 等. 32株银杏内生真菌清除DPPH自由基活性的比较研究[J]. 安徽工程大学学报, 2013, 28(1): 1-4.
[13] 缪莉, 王元元, 朱磊, 等. 四种植物内生真菌的分离及其抗肿瘤活性的筛选[J]. 微生物学通报, 2009, 36(6): 865-869.
[14] 嵇玉峰, 黄金活, 梁洪江. 银杏提取物抗肿瘤作用的实验研究[J]. 中医研究, 2005, 18(7): 14-16.
[15] Isah, T. (2015) Rethinking Ginkgo biloba L.: Medicinal Uses and Conservation. Pharmacognosy Reviews, 9, 140-148.
https://doi.org/10.4103/0973-7847.162137
[16] 王成章, 沈兆邦, 郑光耀, 等. 银杏叶聚戊烯基磷酸酯体内外抗肿瘤的生物活性研究[J]. 林产化学与工业, 2006, 26(3): 13-16.
[17] 许爱华, 陈华圣, 褚澄, 等. 银杏外种皮多糖对人癌细胞株的抑制作用及与阿霉素的协同效应[J]. 中国新药杂志, 2000, 9(11): 753-755.
[18] Yan, T., Guo, Z.K., Jiang, R., et al. (2013) New Flavonol and Diterpenoids from the Endophytic Fungus Aspergillus sp. YXf3. Planta Medica, 79, 348-352.