赭曲霉次生代谢产物研究

doi:10.12677/JOCR.2017.52012

期刊菜单

赭曲霉次生代谢产物研究
Study on the Secondary Metabolites of Aspergillus ochraceus

DOI: 10.12677/JOCR.2017.52012, PDF, HTML, XML, 被引量下载: 1,744 浏览: 4,946 科研立项经费支持
作者: 邹琼宇, 黄俊, 张莉, 陈迪钊, 李欣, 贺贵妃, 梁芬芳：湖南省怀化学院，民族药用植物资源研究与利用湖南省重点实验室，化学与化学工程系，湖南怀化；吴海峰：中国医学科学院北京协和医学院，药用植物研究所，中草药物质基础与资源利用教育部重点实验室，北京
关键词: 赭曲霉；赭曲霉毒素；分离鉴定；Aspergillus ochraceus； Ochratoxin； Isolation and Identification

摘要: 目的：研究赭曲霉次生代谢产物。方法：利用多种色谱层析方法分离出次生代谢产物，通过ESI-MS/MS及NMR等波谱方法鉴定结构。结果：共分离鉴定出9种化合物，依次是赭曲霉毒素A(1)、赭曲霉毒素B(2)、neohydroxyaspergillic acid(3)、(3R)-5-hydroxymellein(4)、5,6-dihydropenicillic acid(5)、mesaconic acid(6)、p-hydroxybenzoic acid(7)、circumdatin G(8)、(22E,24R)-ergosta-7,22-diene-3β,5α,6β- triol(9)。结论：化合物3~9为首次从赭曲霉中分离得到的化合物。

Abstract: Objective: To study the secondary metabolites from Aspergillus ochraceus. Methods: The constit-uents were isolated and purified by column chromatography and preparative TLC. Their structures were identified on the basis of comprehensive spectroscopic methods including ESI-MS and spectral data (1H, 13C-NMR). Results: Nine compounds were isolated and identified as ochratoxin A (1), ochratoxin B (2), neohydroxyaspergillic acid (3), (3R)-5-hydroxymellein (4), 5,6-dihydro- penicillic acid (5), mesaconic acid (6), p-hydroxybenzoic acid (7), circumdatin G (8), (22E,24R)- ergosta-7,22-diene-3β,5α,6β-triol (9). Conclusion: The compounds 3~9 were isolated from Asper-gillus ochraceus for the first time.

文章引用：邹琼宇, 吴海峰, 黄俊, 张莉, 陈迪钊, 李欣, 贺贵妃, 梁芬芳. 赭曲霉次生代谢产物研究[J]. 有机化学研究, 2017, 5(2): 94-99. https://doi.org/10.12677/JOCR.2017.52012

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