ACM  >> Vol. 7 No. 2 (June 2017)

    易致假阳性的抑郁症动物模型研究现状
    Talking about False Positive Reactions of Animal Models of Depression in the Current Research

  • 全文下载: PDF(416KB) HTML   XML   PP.45-51   DOI: 10.12677/ACM.2017.72008  
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作者:  

李 杰,李晋奇:成都中医药大学,四川省人民医院,四川 成都

关键词:
抑郁症动物模型假阳性反应Depression Animal Models False Positive Reaction

摘要:

抑郁症是最常见的精神类疾病,预计到2020年,将上升为世界第二大疾病。随着对抑郁症研究的深入,通过对疾病的发病特点、行为体征、生理生化、病理特点的部分或局部模拟,抑郁症动物模型被广泛地应用于临床前抗抑郁药物的药效学评价和药效作用机制研究,但抑郁症动物模型模拟临床的可靠性和准确性略差,研究过程中各种因素干扰易呈现出的阳性反应。本文主要介绍了常见的易出现假阳性抑郁症动物模型及其改善措施,为抗抑郁药物的药效学评价和药效作用机制研究提供参考。

Depression is the most common psychiatric disorder, by 2020, which is expected to rise to the world's second major disease. With the further research of Depression, animal models of depression are widely used in the preclinical pharmacodynamic evaluation and study on mechanism of drug action through the particial imitation to disease characteristics, behavioral signs, physiological, biochemical and pathological characteristics of the disease. However, reliability and accuracy, which are showed in clinical imitation, to some extent, are still needed improved. It’s likely to be a false positive reaction during the research process caused by different reasons. The essay intended to introduce several common animal models that are easy to be false positive and some promoted solutions, in order to provide a conference for the antidepressant drugs’ pharmacodynamic evaluation and study on mechanism of drug action.

文章引用:
李杰, 李晋奇. 易致假阳性的抑郁症动物模型研究现状[J]. 临床医学进展, 2017, 7(2): 45-51. https://doi.org/10.12677/ACM.2017.72008

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