自噬与老年病的研究进展
Autophagy and Age-Related Diseases
DOI: 10.12677/HJBM.2017.73006, PDF, HTML, XML, 下载: 1,701  浏览: 4,952 
作者: 赵 丹, 刘玉萍, 王 硕, 钟卫权*：徐州医科大学医学技术学院，江苏 徐州；吴继周：徐州医科大学公共卫生学院，江苏 徐州
关键词: 自噬；自噬调控机制；老年病；Autophagy； Regulatory Mechanisms of Autophagy； Age-Related Diseases
摘要: 随着我国老龄化社会的加剧，神经系统、免疫系统和心血管系统等人体系统会出现一系列问题，严重影响老年人的健康和生活质量。机体通过自噬清除错误折叠和变性的蛋白质，以实现细胞自我更新及机体的新陈代谢，自噬在多种老年病的发生发展中发挥重要作用。本文着重综述自噬的类型、自噬的调控机制以及自噬在几种老年病中的研究进展，为老年病的临床治疗提供方向。
Abstract: Since the aging society in our country, the nervous system, cardiovascular system and immune system of human will appear a series of problems, which have serious impact on the health and life quality of old people. The body takes advantage of autophagy to clear misfolding and degenerative protein in order to realize the self-renewal of the cell and the metabolism of the body. Autophagy plays an important role in a variety of age-related diseases. This paper will discuss the types of autophagy and regulatory mechanisms of autophagy and the research progress of several kinds of age-related diseases, and provide the direction for the clinical treatment of age-related diseases.
文章引用：赵丹, 刘玉萍, 吴继周, 王硕, 钟卫权. 自噬与老年病的研究进展[J]. 生物医学, 2017, 7(3): 31-36. https://doi.org/10.12677/HJBM.2017.73006

参考文献

[1] 钱帅伟, 罗艳蕊, 漆正堂, 等. 细胞自噬的分子学机制及运动训练的调控作用[J]. 体育科学, 2012, 32(1): 64-70.
[2] 韦勇, 杨四军. 细胞自噬的调控与自噬程序性死亡的研究进展[J]. 国际免疫学杂志, 2016, 39(5): 493-497.
[3] Alavian, S.M., Ande, S.R., Coombs, K.M., et a1. (2011) Virus Triggered Autophagy in Viral Hepatitis-Possible Novel Strategies for Drug Development. Journal of Viral Hepatitis, 18, 82l-830.
[4] 董会月, 路君, 林灵婧, 谭建明. ULK1复合物在细胞自噬中的作用[J]. 中华细胞与干细胞杂志(电子版), 2016(4): 240-242.
[5] Li, X., He, L., Che, K.H., et a1. (2012) Imperfect Interface of Beclin-1 Coiled-Coil Domain Regulates Homodimer and Heterodimer Formation with At 914I. and UVRAG. Nature Communications, 3, 662.
[6] Cao, Y. and Klionsky, D.J. (2007) Physiological Fmctions 0f Atg6/Beclinl: Aunique Autophagy-Related Protein. Cell Research, 17, 839-849.
[7] Wang, C., Zhang, X., Teng, Z.P., et al. (2014) Downregulation of PI3K/Akt/mTOR Signaling Pathway in Curcumin-Induced Autophagy in APP/PS1 Double Transgenic Mice. European Journal of Pharmacology, 740, 312-320.
[8] Rui, Y.N. and Le, W.D. (2015) Selective Role of Autophagy in Neuronal Function and Neurodegenerative Diseases. Neuroscience Bulletin, 31, 379-381.
[9] Takahashi, Y., Coppola, D., Matsushita, N., et al. (2007) Bif-1 Interacts with Beclin 1 through UVRAG and Regulates Autophagy and Turnorigenesis. Nature Cell Biology, 9, 1142-1151.
[10] 魏星, 李文星. 自噬的相关研究进展[J]. 中华临床医师杂志(电子版), 2015(13): 2564-2568.
[11] 安吉洋, 周丽丽, 庞宏刚, 等. AMPK信号通路在蛛网膜下腔出血后自噬激活中的作用及机制[J]. 中华神经医学杂志, 2015, 14(11): 1095-1099.
[12] 邹书仙, 宋伦. p53在细胞自噬发生中的双重调节作用[J]. 军事医学, 2016, 40(6): 535-536.
[13] 赵金香, 张强, 李耀华. 肿瘤抑制基因p53与自噬[J]. 现代肿瘤医学, 2011, 19(9): 1896-1899.
[14] Nixon, R.A. (2013) The Role of Autophagy in Neurodegenerative Disease. Nature Medicine, 19, 983-997.
[15] Salminen, A., Kaarniranta, K., et al. (2013) Impaired Autophagy and APP Processing in Alzheimer’s Disease: The Potential Role of Beclin1 Interactome. Progress in Neurobiology, 107, 33-54.
[16] Di Scala, C., Chahinian, H., Yahi, N., et al. (2014) Interaction of Alzheimer’s β-Amyloid Peptides with Cholesterol: Mechanistic Insights into Amyloid Pore Formation. Biochemistry, 53, 4489-4502.
[17] Kitazawa, M., Cheng, D., Tsukamoto, M.R., et al. (2011) Blocking IL1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal β-Catenin Pathway Function in an Alzheimer’s Disease Model. The Journal of Immunology, 187, 6539-6549.
[18] Medina, M. and Avila, J. (2014) New Perspectives on the Role of Tau in Alzheimer’s Disease. Implications for Therapy. Biochemical Pharmacology, 88, 540-547.
[19] 翁任楠, 马晋平. 帕金森病[J]. 世界科学, 2017(2): 16.
[20] 黄阳, 陈洪菊, 朱将虎, 赵凤艳, 屈艺, 母得志. PINK1基因对缺氧缺血性脑损伤新生小鼠细胞凋亡及自噬的影响[J]. 中国当代儿科杂志, 2016(3): 263-269.
[21] Meka, D.P., Muller-Rischart, A.K., Nidadavolu, P., et al. (2015) Parkin Cooperates with GDNF/RET Signaling to Prevent Dopaminergic Neuron Degeneration. Journal of Clinical Investigation, 125, 1873-1885.
[22] Jean-Marc, B. (2015) 亨廷顿舞蹈病: 教学性综述[J]. 中国神经精神疾病杂志, 41(10): 577-591.
[23] Pignataro, G., Capone, D., Polichetli, G., et al. (2011) Neuroprotective, Immunosuppressant and Antineoplastic Properties of mTOR Inhibitors: Current and Emerging Therapeutic Options. Current Opinion in Pharmacology, 11, 378- 394.
[24] 孙鑫, 王进, 秦正红, 等. 自噬及其在亨廷顿舞蹈病发病机制中的作用[J]. 中国神经免疫学和神经病学杂志, 2011, 18(1): 54-57.
[25] 周风华, 刘焕彩, 陈燕春, 鞠杰, 蒲雷东, 王巧真, 接琳琳, 丁昊宇. 自噬相关基因Atg4B及LC3-Ⅱ在肌萎缩侧索硬化症转基因鼠海马中的表达及意义[J]. 中国老年学杂志, 2015(12): 3216-3218.
[26] 刘永新, 管英俊, 陈燕春, 王巧真, 接琳琳, 周风华, 张皓云, 卢强. 肌萎缩侧索硬化症转基因小鼠脊髓中自噬相关基因ATG5表达降低[J]. 中国组织化学与细胞化学杂志, 2016(2): 107-111.
[27] Darrieutort-Laffite, C., Boutet, M.A., Chatelais, M., et al. (2014) IL-β and TNF-α Promote Monocyte Viability through the Induction of GM-CSF Expression by Rheumatoid Arthritis Synovial Fibroblasts. Mediators of Inflammation, 2014, Article ID: 241840.
[28] 王丹, 韩晓蕾, 郝晟瑜, 李秋婷, 邱春红. 细胞自噬在自身免疫性疾病中的调控作用研究进展[J]. 细胞与分子免疫学杂志, 2015(10): 1429-1432.
[29] Zhu, L., Wang, H., Wu, Y., He, Z., Qin, Y. and Shen, Q. (2017) The Autophagy Level Is Increased in the Synovial Tissues of Patients with Active Rheumatoid Arthritis and Is Correlated with Disease Severity. Mediators of Inflammation, 2017, Article ID: 7623145.
https://doi.org/10.1155/2017/7623145
[30] 徐俊杰, 王志莲, 郝敏. 细胞自噬与肿瘤的研究进展[J]. 中华临床医师杂志(电子版), 2016, 10(5): 701-706.
[31] 唐珍, 王含彦, 易芳, 郭冬梅, 罗蓉. 自噬对衰老的调节及其在肿瘤发生发展中作用的研究进展[J]. 吉林大学学报: 医学版, 2015(4): 877-880.
[32] Mani, J., Vallo, S., Rakel, S., et al. (2015) Chemoresistance Is Associated with Increased Cytoprotective Autophagy and Diminished Apoptosis in Bladder Cancer Cells Treated with the BH3 Mimetic-Gossypol(AT-101). BMC Cancer, 15, 224.
[33] 魏艳杰, 田炜. 自噬及其在肿瘤发生发展中作用的研究进展[J]. 中国医学创新, 2016, 13(23): 137-140.
[34] Wu, M.Y., Fu, J., Xu, J., O’Malley, B.W. and Wu, R.C. (2012) Steroid Receptor Cactivator 3 Regulates Autophagy in Breast Cancer Cells through Macrophage Migration Inhibitory Factor. Cell Research, 22, 1003-1021.

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