白内障合并糖尿病非增殖性视网膜病变患者术前局部使用双氯芬酸钠降低眼内IL-12浓度

Cataract Combined with Diabetic Non-Proliferative Retinopathy Reduced the Concentration of IL-12 in the Eye with Diclofenac

摘要: 目的：探讨白内障合并糖尿病非增殖性视网膜病变患者行白内障摘除手术前，局部使用双氯芬酸钠是否降低房水中IL-12浓度。方法：选取在我院拟接受手术治疗的38例白内障合并糖尿病非增殖性视网膜病变患者，随机分配为双氯芬酸钠观察组组和安慰剂对照组，对比分析两组研究对象房水中IL-12水平。其中双氯芬酸钠组17名，安慰剂组21名。双氯芬酸钠组患者在行白内障手术前10天，局部使用0.1%双氯芬酸钠4/日，术后继续用药30天。安慰剂组患者术前局部使用安慰剂10天，4/日，术后规范使用白内障术后用药共30天。所有患者术后均使用抗生素预防感染(妥布霉素滴眼液4/日)，术后用药时间为30天。白内障手术术前收集房水样本用以测量IL-12浓度。结果：双氯芬酸钠组患者房水中IL-12浓度明显低于安慰剂组。结论：IL-12在发生黄斑水肿的糖尿病性白内障患者房水中明显升高。此类患者行超声乳化吸除术后联合植入人工晶体治疗时，于术前应用双氯芬酸钠，术后联合抗生素类药物治疗，可有效减少黄斑水肿的发生，提高术后视力。

Abstract: Objective: To investigate whether the partial use of diclofenac sodium in the treatment of cataract combined with diabetic non-proliferative retinopathy can reduce IL-12 concentration in the aqueous water. Methods: 38 cases of cataract patients with diabetes mellitus not hyperplastic ret-inopathy to accept the surgical treatment in our hospital, are randomly assigned for diclofenac so-dium observation way and the placebo group, aqueous humor IL-12 levels are compared in re-search object of the two groups. There were 17 in diclofenac sodium and 21 in the placebo group. The patients of diclofenac sodium group were treated with 0.1% diclofenac 4/d and 30 days after surgery for 10 days before cataract surgery. In the placebo group, patients were given a placebo 10 days, 4/d, and postoperative standardized use of cataract surgery for 30 days. All patients were treated with antibiotic prophylaxis (tobramycin eye drops 4/d) after surgery and 30 days after surgery. Water samples collected before the operation of cataract was used to measure IL-12 con-centration. Result: The concentration of IL-12 in the patients with diclofenac sodium was signifi-cantly lower than that in the placebo group. Conclusion: IL-12 was significantly elevated in diabetic patients with diabetic cataract. Such patients when get ultrasonic emulsification therapy gettering postoperative combined implantation of artificial crystal, should apply the preoperative diclofenac sodium, combine postoperative antibiotic drug therapy, which can effectively reduce the occurrence of macular edema, improve visual acuity.