瞳神紧小方治疗前葡萄膜炎风湿夹热型的临床观察

Clinical Observation on Effect of Tongshenjinxiao Prescription for Acute Anterior Uveitis with Syndrome of Wind Heat Dampness

摘要: 目的：观察瞳神紧小方对风湿夹热型急性前葡萄膜炎患者临床疗效。方法：将诊断为风湿夹热型急性前葡萄膜炎患者60例，随机分为对照组和治疗组，治疗组予瞳神紧小方、美多丽和典必殊治疗，对照组仅予美多丽和典必殊治疗。随访观察2周，比较2组疗效。结果：1) 视力疗效：治疗一周、二周，治疗组视力有效率分别为86.67%、96.6%，对照组视力有效率分别为60%、83%。治疗一周、二周后组间差异有统计学意义(P < 0.05)。2) 眼前节体征：治疗1周、2周后，治疗组在改善睫状充血、角膜后沉积物、房水闪辉、浮游细胞的体征方面均明显优于对照组，差异有统计学意义。3) 中医症候疗效：治疗组在治疗一周、二周后的总有效率分别为：93.33%，93.33%，对照组的总有效率分别为63.33%，73.33%，治疗组各时间节点疗效均好于对照组(P < 0.05)。结论：瞳神紧小方对治疗风湿夹热型急性前葡萄膜炎可明显改善眼前节体征，提高视力，并可改善风湿夹热症状。

Abstract: Objective: To observe the clinical effect of Tongshenjinxiao prescription for acute anterior uveitis with syndrome of wind heat dampness. Methods: Sixty patients (60 eyes) of acute anterior uveitis with syndrome of wind heat dampness were randomly divided into control group and treatment group as research object according to the diagnostic criteria. The treatment group was treated with Tongshenjinxiao prescription, tropicamide phenylephrine eye drops and tobradex eye drops. The control group was treated with tropicamide phenylephrine eye drops and tobradex eye drops. Follow up observation lasted for 2 weeks, the effects of the 2 groups were compared. Result: 1) The curative effect of vision: After 1 week and 2 weeks, the vision efficiency of the treatment group was 60% and 83% respectively while the counterpart of control group was 60% and 83%. 1 week and 2 weeks after treatment, the difference between groups was statistically significant (P < 0.05). 2) Anterior segment sign: 1 week and 2 weeks after treatment, the treatment group was superior to the control group in improving the ciliary congestion, posterior corneal sediment, aqueous humor and planktonic cell signs. The difference between groups was statistically significant (P < 0.05). 3) The curative effect of TCM syndrome: after 1 week, 2 weeks, the total effective rate of the treatment group was 93.33% and 93.33% respectively while the results of control group was 63.33% and 73.33%. At each time point, the curative effect in treatment group was better than that in control group (P < 0.05). Conclusion: Tongshenjinxiao prescription was used to treat acute anterior uveitis with syndrome of wind heat dampness. It could significantly improve the anterior segment signs, visual acuity and relieve symptoms of wind heat dampness.