外泌体生物学特性及其在肝癌中的作用研究
Biological Characteristics of Exosomes and Their Role in Hepatocellular Carcinoma
DOI: 10.12677/WJCR.2018.81003, PDF,  被引量    国家自然科学基金支持
作者: 张腾飞:上海交通大学附属第六人民医院普外科,上海;安徽医科大学附属巢湖医院普外科,安徽 合肥;黄修燕*:上海交通大学附属第六人民医院普外科,上海
关键词: 肝细胞肝癌外泌体miRNA生物标记分子Hepatocellular Carcinoma Exosomes miRNA Biomarker
摘要: 肝细胞癌(HCC)发生发展的分子机制尚未完全清楚,可能涉及病毒致癌作用、癌基因和抑癌基因失活、癌细胞凋亡等。外泌体能介导细胞间物质传递和信息交流,在多种癌症发生发展中起着重要作用。本文旨在总结外泌体生物学特性及其在肝癌发生发展、诊断和治疗中的作用。
Abstract: The mechanism of hepatocellular carcinoma (HCC) development is not yet fully understood, which may be related to the carcinogenesis of the virus, the inactivation of oncogenes and tumor sup-pressor genes, cancer cell apoptosis. Exosomes, which can mediate the material transfer between cells and the exchange of information, play significant roles in the occurrence and development of a variety of cancers. This article aims to summarize the biological characteristics of exosomes and their roles in the development, diagnosis and treatment of HCC.
文章引用:张腾飞, 黄修燕. 外泌体生物学特性及其在肝癌中的作用研究[J]. 世界肿瘤研究, 2018, 8(1): 12-17. https://doi.org/10.12677/WJCR.2018.81003

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