细胞穿膜肽的研究概况
Review on the Research of Cell-Penetrating Peptides
DOI: 10.12677/AMS.2018.52004, PDF,    国家自然科学基金支持
作者: 陈月如, 胡 倩, 郭华荣*：中国海洋大学海洋生命学院，海洋生物遗传学与育种教育部重点实验室，山东 青岛；毋梦茜：中国海洋大学海洋生物多样性与进化研究所，山东 青岛
关键词: 细胞穿膜肽；结构；分类；穿膜机制；癌症治疗；海洋生物；Cell-Penetrating Peptides； Structure； Classification； Transmembrane Mechanism； Cancer Therapy； Marine Biology
摘要: 生物大分子在许多疾病的治疗中发挥着重要的作用，但由于细胞膜的天然屏障作用，使得这些生物大分子的实际应用受到限制。细胞穿膜肽(cell-penetrating peptides，CPPs)是一类具有较强跨膜转运能力的小分子肽，可携带多肽、蛋白质和核酸等多种大分子物质进入细胞，开辟了外源物质进入细胞的新途径。细胞穿膜肽作为一种新型递送工具，具有广阔的应用前景。本文综述了细胞穿膜肽的分类、穿膜机制及其作为转运载体在癌症治疗以及海洋生物中的应用。
Abstract: Although biomacromolecules play an important role in the treatment of many diseases, its practical application is limited due to the natural barrier of the cell membrane. Cell-penetrating peptides are a kind of small molecular peptides with remarkable capacity for membrane translocation and can carry various macromolecules into cells including peptides, proteins, nucleic acids, and so on, opening a new way for exogenous substances to enter into cells. As a novel delivery tool, CPPs have promising application prospect. In this paper, we reviewed the classification and transmembrane mechanism of CPPs, and its use in the cancer therapy and marine biology as carrier.
文章引用：陈月如, 毋梦茜, 胡倩, 郭华荣. 细胞穿膜肽的研究概况[J]. 海洋科学前沿, 2018, 5(2): 29-37. https://doi.org/10.12677/AMS.2018.52004

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