胎盘部位滋养细胞肿瘤2例临床分析及文献复习
Placental Site Trophoblastic Tumor: A Study of Two Cases and a Review of the Literature
摘要: 目的：探讨胎盘部位滋养细胞肿瘤的临床诊疗。方法：选择2012年1月至2016年1月广东省妇幼保健院妇科收治的2例胎盘部位滋养细胞肿瘤患者临床资料进行分析研究。结果：2例患者前次妊娠均为足月妊娠，距离前次妊娠时间平均6+月，诊断时血人绒毛膜促性腺激素(hcg)平均为380 IU/L，其中一例行全子宫切除术；另一例行5-fu + Act-d方案化疗。2例患者均存活，随访至今无复发。结论：胎盘部位滋养细胞肿瘤发病率低，多继发于足月妊娠，血HCG水平低，治疗首选子宫切除术，有高危因素的患者应在手术基础上联合化疗。
Abstract: Objective: To investigate the clinical diagnosis and treatment of placental site trophoblastic tumor (PSTT). Methods: Analysis was conducted on the clinical data of 2 patients with PSTT admitted in gynecology department of women and children hospital of Guangdong province during the period of January 2012 to January 2016. Results: Previous pregnancy was full term in 2 cases. The mean interval from previous pregnancy to the diagnosis was 6 months. The mean level of human chori-onic gonadotropin (hCG) was 380 IU/L. One patient was cured by hysterectomy, and the other one was cured by 5-fu and ACT-D chemotherapy. The 2 patients were alive up to now with no recurrence. Conclusion: PSTT is rare, and most previous pregnancy is full term. The level of hCG is low. Hysterectomy is the primary choice of treatment. Chemotherapy should be given to the high-risk cases based on hysterectomy.
文章引用：徐丽群, 熊文雯, 张凌, 徐珍, 李智敏, 陈文芬. 胎盘部位滋养细胞肿瘤2例临床分析及文献复习[J]. 亚洲肿瘤科病例研究, 2018, 7(4): 56-60. https://doi.org/10.12677/ACRPO.2018.74009

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