SHR-1210对食管癌术后患者心脏功能的影响

Effect of SHR-1210 on Cardiac Function in Patients after Esophageal Cancer Operation

摘要: 目的：应用组织多普勒技术(Tissue Doppler Imaging, TDI)对服用SHR-1210治疗的食管癌术后双心室功能回顾比较，探讨术后2年期使用该类药物对心脏功能的影响。方法：比对42例食管癌术后患者使用该类药物前、后二尖瓣侧壁瓣环、间隔瓣环及右室侧壁瓣环舒张期运动速度，右室侧壁瓣环M型运动幅度以及左心室射血分数。结果：服用药物前后左心室二尖瓣侧壁瓣环、间隔瓣环及右室侧壁瓣环舒张期运动速度均明显减低(P < 0.05)；左心室、右心室收缩功能无明显变化(P > 0.05)。结论：服用SHR-1210两年治疗期的食管癌患者左心室、右心室收缩功能无明显变化，但双心室舒张功能均明显降低，提示该类药物可能损害心肌功能。

Abstract: Objective: To evaluate the effect of two-year postoperative 2-week period on the function of patients with esophageal cancer treated with SHR-1210 using tissue Doppler imaging (TDI) technique. Methods: the levee anterior and posterior mitral valve sidewall annulus, spacer annulus and right ventricular sidewall anastomosis, Right ventricular sidewall annulus M-type motion Amplitude and left ventricular ejection fraction of 42 patients with esophageal cancer after operation were compared. Results: The left ventricular mitral valve valvular annulus, septum annulus and right ventricular wall anastomosis were significantly decreased before and after taking the drug (P < 0.05). There was no significant change in left ventricular and right ventricular systolic function (P > 0.05). Conclusion: There is no significant change in left ventricular and right ventricular systolic function in patients with esophageal cancer who have been treated with SHR-1210 for two years, but the diastolic function of both ventricles is significantly reduced, suggesting that this drug may impair myocardial function.